Evidence map›Paper›PMID 37952204›Full record

ArticleEuropean heart journal2024

Clonal haematopoiesis of indeterminate potential predicts incident cardiac arrhythmias.

Art Schuermans, Caitlyn Vlasschaert, Victor Nauffal, So Mi Jemma Cho, Md Mesbah Uddin, Tetsushi Nakao, Abhishek Niroula, Marcus D R Klarqvist, Lachelle D Weeks, Amy E Lin and 13 more

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Article in European heart journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
14.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.

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  4. Arteriosclerosis, thrombosis, and vascular biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 8 institutions in 5 countries.

Art SchuermansProgram in Medical and Population Genetics and Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, 75 Ames St., Cambridge, MA 02142, USA.ORCID 0000-0001-8146-9692
Caitlyn VlasschaertDepartment of Medicine, Queens University, Kingston, ON, Canada.
Victor NauffalProgram in Medical and Population Genetics and Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, 75 Ames St., Cambridge, MA 02142, USA.ORCID 0000-0001-7199-299X
So Mi Jemma ChoProgram in Medical and Population Genetics and Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, 75 Ames St., Cambridge, MA 02142, USA.
Md Mesbah UddinProgram in Medical and Population Genetics and Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, 75 Ames St., Cambridge, MA 02142, USA.ORCID 0000-0003-1846-0411
Tetsushi NakaoProgram in Medical and Population Genetics and Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, 75 Ames St., Cambridge, MA 02142, USA.
Abhishek NiroulaProgram in Medical and Population Genetics and Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, 75 Ames St., Cambridge, MA 02142, USA.
Marcus D R KlarqvistData Sciences Platform, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Lachelle D WeeksDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Amy E LinDivision of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Seyedmohammad SaadatagahDepartment of Medicine, Baylor College of Medicine, Houston, TX, USA.
Kim LanneryProgram in Medical and Population Genetics and Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, 75 Ames St., Cambridge, MA 02142, USA.
Megan WongProgram in Medical and Population Genetics and Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, 75 Ames St., Cambridge, MA 02142, USA.ORCID 0000-0003-4135-633X
Whitney HornsbyProgram in Medical and Population Genetics and Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, 75 Ames St., Cambridge, MA 02142, USA.
Steven A LubitzProgram in Medical and Population Genetics and Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, 75 Ames St., Cambridge, MA 02142, USA.ORCID 0000-0002-9599-4866
Christie BallantyneDepartment of Medicine, Baylor College of Medicine, Houston, TX, USA.
Siddhartha JaiswalDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Peter LibbyDivision of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0002-1502-502X
Benjamin L EbertDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Alexander G BickDivision of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Patrick T EllinorProgram in Medical and Population Genetics and Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, 75 Ames St., Cambridge, MA 02142, USA.ORCID 0000-0002-2067-0533
Pradeep NatarajanProgram in Medical and Population Genetics and Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, 75 Ames St., Cambridge, MA 02142, USA.ORCID 0000-0001-8402-7435
Michael C HonigbergProgram in Medical and Population Genetics and Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, 75 Ames St., Cambridge, MA 02142, USA.ORCID 0000-0001-8630-5021
Broad Institute · USBaylor College of Medicine · USBrigham and Women's Hospital · USDana-Farber Cancer Institute · USHoward Hughes Medical Institute · USQueen's University · CAStanford University · USVanderbilt University Medical Center · US

Funding

IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVALR01HL092577 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI BENJAMIN, EMELIA J., ELLINOR, PATRICK THOMAS · 2009 to 2025
$20.6M
Clonal hematopoiesis in humans: determinants of development and progressionR01HL148050 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI BALLANTYNE, CHRISTIE MITCHELL, NATARAJAN, PRADEEP · 2019 to 2022
$5.9M
Genomics of Cardiac ArrhythmiasR01HL139731 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI ELLINOR, PATRICK THOMAS · 2018 to 2022
$3.3M
CLONAL HEMATOPOIESIS OF INDETERMINATE POTENTIAL IN CHRONIC KIDNEY DISEASE PATIENTSR01DK125782 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KELLY, TANIKA NICOLE · 2021 to 2025
$3.3M
Mechanisms and Modulation of Accelerated Atherosclerosis in Clonal HematopoiesisR01HL163099 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LIBBY, PETER · 2022 to 2025
$2.6M
Clonal hematopoiesis in human aging and diseaseDP2HL157540 · NHLBI · STANFORD UNIVERSITY · PI JAISWAL, SIDDHARTHA · 2020 to 2020
$2.4M
Clonal hematopoiesis as a mediator of cardiovascular disease in women with premature menopauseK08HL166687 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI HONIGBERG, MICHAEL · 2023 to 2025
$507k
Using genomic modifiers to mechanistically link clonal hematopoiesis of indeterminate potential penetrance to coronary artery diseaseK99HL165024 · NHLBI · BROAD INSTITUTE, INC. · PI NAKAO, TETSUSHI · 2023 to 2024
$334k
NHLBI NIH HHS 1R01HL134892NHLBI NIH HHS DP2 HL157540NHLBI NIH HHS K08 HL166687NHLBI NIH HHS K99 HL165024NHLBI NIH HHS R01 HL092577NHLBI NIH HHS R01 HL163099NIDDK NIH HHS R01 DK125782NIDDK NIH HHS R01DK125782NIH HHS R01HL139731
6 · The paper itself

Abstract

BACKGROUND AND

aimsClonal haematopoiesis of indeterminate potential (CHIP), the age-related expansion of blood cells with preleukemic mutations, is associated with atherosclerotic cardiovascular disease and heart failure. This study aimed to test the association of CHIP with new-onset arrhythmias.

methodsUK Biobank participants without prevalent arrhythmias were included. Co-primary study outcomes were supraventricular arrhythmias, bradyarrhythmias, and ventricular arrhythmias. Secondary outcomes were cardiac arrest, atrial fibrillation, and any arrhythmia. Associations of any CHIP [variant allele fraction (VAF) ≥ 2%], large CHIP (VAF ≥10%), and gene-specific CHIP subtypes with incident arrhythmias were evaluated using multivariable-adjusted Cox regression. Associations of CHIP with myocardial interstitial fibrosis [T1 measured using cardiac magnetic resonance (CMR)] were also tested.

resultsThis study included 410 702 participants [CHIP: n = 13 892 (3.4%); large CHIP: n = 9191 (2.2%)]. Any and large CHIP were associated with multi-variable-adjusted hazard ratios of 1.11 [95% confidence interval (CI) 1.04-1.18; P = .001] and 1.13 (95% CI 1.05-1.22; P = .001) for supraventricular arrhythmias, 1.09 (95% CI 1.01-1.19; P = .031) and 1.13 (95% CI 1.03-1.25; P = .011) for bradyarrhythmias, and 1.16 (95% CI, 1.00-1.34; P = .049) and 1.22 (95% CI 1.03-1.45; P = .021) for ventricular arrhythmias, respectively. Associations were independent of coronary artery disease and heart failure. Associations were also heterogeneous across arrhythmia subtypes and strongest for cardiac arrest. Gene-specific analyses revealed an increased risk of arrhythmias across driver genes other than DNMT3A. Large CHIP was associated with 1.31-fold odds (95% CI 1.07-1.59; P = .009) of being in the top quintile of myocardial fibrosis by CMR.

conclusionsCHIP may represent a novel risk factor for incident arrhythmias, indicating a potential target for modulation towards arrhythmia prevention and treatment.

Indexed as

Atrial FibrillationHeart ArrestHeart FailureBradycardiaClonal HematopoiesisHumansAgingArrhythmiaAtrial fibrillationCardiac arrestGenomicsPrevention

Identifiers

PMID37952204
PMCPMC10919923
OpenAlexW4388608383

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.