ArticleBMC pregnancy and childbirth2023
Reference intervals of complete blood count and coagulation tests in Vietnamese pregnant women.
Article in BMC pregnancy and childbirth, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05929326 (Establishment of Reference Intervals of Complete Blood Count and Coagulation Tests in Pregnant Women at Hung Vuong Hospital), which is not on this map. Cited by 5 papers.
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Establishment of Reference Intervals of Complete Blood Count and Coagulation Tests in Pregnant Women at Hung Vuong Hospital
Who cites it
5 citing papers in PubMed, 6 citations in OpenAlex.
- Establishing trimester-specific reference intervals for coagulation parameters in pregnant women in China.BMC pregnancy and childbirth · 2026Article
- Hematological Predictors of Impaired Postpartum Uterine Involution in Thrombophilia: A Multivariate Analysis.Diagnostics (Basel, Switzerland) · 2026Article
- Reference Intervals of Hematological Parameters Among Healthy Pregnant Women in Eastern Sudan: A Prospective Longitudinal Cohort Study.International journal of women's health · 2026Article
- Physiological Changes and Trimester-Specific Reference Intervals for Complete Blood Count Parameters in Korean Pregnant Women.Medicina (Kaunas, Lithuania) · 2025Article
- Coagulation parameters correlate to venous thromboembolism occurrence during the perioperative period in patients with spinal fractures.Journal of orthopaedic surgery and research · 2023Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPregnancy has major effects that make hematology parameters outside of normal reference ranges. Therefore, we conducted this study to establish reference intervals for Vietnamese pregnant women.
methodsFrom June 2023 to Augst 2023, blood samples from 879 eligible pregnant women were run on DxH 900 hematology analyzer and ACL TOP 550 coagulation analyzer. The tested parameters are prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB), white blood cell (WBC) and its differentials (neutrophils, lymphocytes, monocytes, eosinophils and basophils), red blood cell (RBC), hemoglobin (HGB), hematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), RBC distribution width (RDW), RBC distribution width standard deviation (RDW-SD), platelet count (PLT), mean platelet volume (MPV). A non-parametric method was used to establish the 2.5
resultsPT, APTT decrease but fibrinogen increases during pregnancy. Physiological adaptations of pregnancy result in a decrease in RBC count, but an increase in WBC count and no changes in platelet count. The reference intervals for PT (seconds), APTT (seconds), fibrinogen (mg/dL), in the first trimester were 10.30-12.88, 25.40-35.46, 280.28-559.00, in the second trimester were 9.80-11.66, 24.05-33.23, 347.75-593.35, in the third trimester were 9.60-11.40, 23.40-31.80, 330.28-628.56, respectively. The reference intervals for main hematology parameters which are WBC (× 10
conclusionsMost established referenced intervals from each trimester differ from other trimesters. These trimester-specific reference ranges for Vietnamese pregnant women will aid clinicians in entepreting parameters and help other laboratories adopt these ranges after validating.
trial registrationThis study is registered at www. CLINICALTRIALS: gov as NCT05929326.
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