Evidence map›Paper›PMID 37951587›Full record

ArticleBioinformatics (Oxford, England)2023

Penalized regression with multiple sources of prior effects.

Armin Rauschenberger, Zied Landoulsi, Mark A van de Wiel, Enrico Glaab

Abstract read
In one paragraph

Article in Bioinformatics (Oxford, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Armin RauschenbergerLuxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, 4362 Esch-sur-Alzette, Luxembourg.ORCID 0000-0001-6498-4801
Zied LandoulsiLuxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, 4362 Esch-sur-Alzette, Luxembourg.ORCID 0000-0002-2327-3904
Mark A van de WielDepartment of Epidemiology and Data Science (EDS), Amsterdam University Medical Centers (Amsterdam UMC), 1081 HV Amsterdam, The Netherlands.ORCID 0000-0003-4780-8472
Enrico GlaabLuxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, 4362 Esch-sur-Alzette, Luxembourg.ORCID 0000-0003-3977-7469

Funding

Wellcome Trust
6 · The paper itself

Abstract

motivationIn many high-dimensional prediction or classification tasks, complementary data on the features are available, e.g. prior biological knowledge on (epi)genetic markers. Here we consider tasks with numerical prior information that provide an insight into the importance (weight) and the direction (sign) of the feature effects, e.g. regression coefficients from previous studies.

resultsWe propose an approach for integrating multiple sources of such prior information into penalized regression. If suitable co-data are available, this improves the predictive performance, as shown by simulation and application. AVAILABILITY AND IMPLEMENTATION: The proposed method is implemented in the R package transreg (https://github.com/lcsb-bds/transreg, https://cran.r-project.org/package=transreg).

Indexed as

SoftwareComputer SimulationImplementation Science

Identifiers

PMID37951587
PMCPMC10699841

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.