ArticleOsteoarthritis and cartilage2024
Genetic association between atopic disease and osteoarthritis.
Article in Osteoarthritis and cartilage, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Association between digestive diseases and symptomatic knee osteoarthritis in Chinese participants: a prospective cohort study.BMC public health · 2026Article
- Supervised machine learning model to predict total knee replacement in a large osteoartrhitis real-world evidence dataset using retrospectively 20-year insurance data from Israel.BMC medical informatics and decision making · 2026Article
- The causal link between osteoarthritis and falls: the mediating role of paracetamol.Aging clinical and experimental research · 2025Article
- Asthma, social isolation and loneliness, and risk of incident osteoarthritis.Arthritis research & therapy · 2025Article
- Causal factors for osteoarthritis risk revealed by mendelian randomization analysis.Aging clinical and experimental research · 2024Review
- Genetic evidence of the causal relationship between chronic liver diseases and musculoskeletal disorders.Journal of translational medicine · 2024Article
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
objectivesTo evaluate the association between genetically determined risk for atopic disease and osteoarthritis (OA).
methodsWe performed linkage disequilibrium (LD) score regression using 1000 Genomes Project European samples as a reference for patterns of genome-wide LD. Summary statistics for atopic disease traits were obtained from the UK Biobank. We generated a pairwise genetic correlation between OA and traits for atopic disease to estimate the genetic correlation between traits (r
resultsThere was a significant positive correlation between the genome-wide genetic architecture of asthma and all OA traits. Using the IVW (random effects), there was a significant association between asthma and knee OA ((odds ratio) OR = 1.04, 95% (confidence interval) CI 1.01-1.08, p = 0.0169). Using IVW (fixed effects), significant associations were identified between knee OA and allergic disease (OR = 1.07, 95% CI 1.01-1.14, p = 0.0342), allergic rhinitis (OR = 1.07, 95% CI 1.00-1.13, p = 0.0368), and asthma (OR = 1.04, 95% CI 1.01-1.07, p = 0.0139), as well as for OA at any site and asthma (OR = 1.02, 95% CI 1.00-1.04, p = 0.0166).
conclusionsWe found a significant correlation between the overall genetic architecture of asthma and OA, as well as an increased risk of developing OA in patients with genetic variants associated with asthma and allergic rhinitis; predominately, this risk was for the development of knee OA. These results support a causal relationship between asthma and/or allergic rhinitis and knee OA.
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