ReviewJournal of industrial microbiology & biotechnology2023
Antifungal activity and mechanism of action of natural product derivates as potential environmental disinfectants.
Review in Journal of industrial microbiology & biotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Efficacy of botanical antifungal and conventional antifungal in the treatment of oral candidiasis: a systematic review and meta-analysis.Frontiers in pharmacology · 2025Pooled it
- Article
- Antifungal efficacy of a novel type of nanosalt against human fungal pathogens and its antifungal mechanisms.Applied microbiology and biotechnology · 2026Article
- The effectiveness of Annona muricata for improving induced oral candidiasis in gamma-irradiated rats.BMC complementary medicine and therapies · 2026Article
- Lactic Acid Bacteria for Fungal Control and Shelf-Life Extension in Fresh Pasta: Mechanistic Insights and Clean-Label Strategies.Molecules (Basel, Switzerland) · 2026Review
- Article
- Accelerated Full-Thickness Wound Healing by a Topical Ointment Formulated withInternational journal of molecular sciences · 2025Article
- Evaluation of Phytotoxic and Cytotoxic Effects of Prenylated Phenol Derivatives on Tomato Plants (Plants (Basel, Switzerland) · 2025Article
- Optimized Combinations of Filtrates ofJournal of fungi (Basel, Switzerland) · 2025Article
- The Role of Oxidative Stress in the Antifungal Activity of Two Mollusk Fractions on Resistant Fungal Strains.International journal of molecular sciences · 2025Article
- Screening of soybean antifungal isoflavones based on targeted metabolomics analysis.Food chemistry: X · 2025Article
- Chemodiversity, biosynthetic regulation, and functional roles ofFrontiers in plant science · 2025Review
- Non-chemical control of fungal pathogens in crops: a one-health perspective on strategies, mechanisms, and future directions.Frontiers in plant science · 2025Review
- Antibacterial, Antifungal, Antiviral Activity, and Mechanisms of Action of Plant Polyphenols.Microorganisms · 2024Review
- In vitro antifungal activities of medicinal plants used for treatment of candidiasis in Pader district, Northern Uganda.Tropical medicine and health · 2024Article
- Research progress on inhibitors and inhibitory mechanisms of mycotoxin biosynthesis.Mycotoxin research · 2024Review
- Phytochemical Profiling, Antioxidant and Antimicrobial Potentials of Ethanol and Ethyl Acetate Extracts ofPharmaceuticals (Basel, Switzerland) · 2024Article
- Antimicrobial Metabolites of Caucasian Medicinal Plants as Alternatives to Antibiotics.Antibiotics (Basel, Switzerland) · 2024Review
- Biomolecular Insights Into the Antifungal Activity ofIranian journal of pharmaceutical research : IJPRArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
There have been a considerable number of antifungal studies that evaluated natural products (NPs), such as medicinal plants and their secondary metabolites, (phenolic compounds, alkaloids), essential oils, and propolis extracts. These studies have investigated natural antifungal substances for use as food preservatives, medicinal agents, or in agriculture as green pesticides because they represent an option of safe, low-impact, and environmentally friendly antifungal compounds; however, few have studied these NPs as an alternative to disinfection/sanitation for indoor air or environmental surfaces. This review summarizes recent studies on NPs as potential fungal disinfectants in different environments and provides information on the mechanisms of inactivation of these products by fungi. The explored mechanisms show that these NPs can interfere with ATP synthesis and Ca++ and K+ ion flow, mainly damaging the cell membrane and cell wall of fungi, respectively. Another mechanism is the reactive oxygen species effect that damages mitochondria and membranes. Inhibition of the overexpression of the efflux pump is another mechanism that involves damage to fungal proteins. Many NPs appear to have potential as indoor environmental disinfectants. ONE-SENTENCE SUMMARY: This review shows the latest advances in natural antifungals applied to different indoor environments. Fungi have generated increased tolerance to the mechanisms of traditional antifungals, so this review also explores the various mechanisms of action of various natural products to facilitate the implementation of technology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.