Evidence map›Paper›PMID 37951204›Full record

ArticleJournal of molecular and cellular cardiology2024

Automated spatially targeted optical micro proteomics identifies fibroblast- and macrophage-specific regulation of myocardial infarction scar maturation in rats.

Venkatesh Mallikarjun, Bocheng Yin, Laura R Caggiano, Sydney Blimbaum, Caitlin M Pavelec, Jeffrey W Holmes, Sarah E Ewald

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular and cellular cardiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Venkatesh MallikarjunDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA 22904, USA.
Bocheng YinDepartment of Microbiology, Immunology and Cancer Biology at the Carter Immunology Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Laura R CaggianoDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA 22904, USA.
Sydney BlimbaumDepartment of Microbiology, Immunology and Cancer Biology at the Carter Immunology Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Caitlin M PavelecDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA 22904, USA.
Jeffrey W HolmesDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA 22904, USA; School of Engineering, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Electronic address: holmesjw@uab.edu.
Sarah E EwaldDepartment of Microbiology, Immunology and Cancer Biology at the Carter Immunology Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA. Electronic address: se2s@virginia.edu.
University of Virginia · US

Funding

INTERDISCIPLINARY TRAINING PROGRAM IN IMMUNOLOGYT32AI007496 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Michael G. Brown, Coleen A McNamara · 1995 to 2026
$10.2M
Innate Inflammatory Control of CachexiaR35GM138381 · NIGMS · UNIVERSITY OF VIRGINIA · PI Sarah E. Ewald · 2020 to 2026
$2.9M
Proteomic interrogation of the parasite vacuole using autoSTOMPR21AI156153 · NIAID · UNIVERSITY OF VIRGINIA · PI EWALD, SARAH E. · 2021 to 2022
$444k
NIAID NIH HHS R21 AI156153NIAID NIH HHS T32 AI007496NIGMS NIH HHS R35 GM138381
6 · The paper itself

Abstract

Myocardial infarction (MI) results from occlusion of blood supply to the heart muscle causing death of cardiac muscle cells. Following myocardial infarction (MI), extracellular matrix deposition and scar formation mechanically stabilize the injured heart as damaged myocytes undergo necrosis and removal. Fibroblasts and macrophages are key drivers of post-MI scar formation, maturation, and ongoing long-term remodelling; however, their individual contributions are difficult to assess from bulk analyses of infarct scar. Here, we employ state-of-the-art automated spatially targeted optical micro proteomics (autoSTOMP) to photochemically tag and isolate proteomes associated with subpopulations of fibroblasts (SMA

Indexed as

CicatrixMyocardial InfarctionAnimalsFibroblastsMacrophagesMyocardiumMyocytes, CardiacProteomicsRatsVentricular RemodelingExtracellular matrixFibroblastsMacrophageMyocardial infarctProteomics

Identifiers

PMID37951204
PMCPMC12699933
OpenAlexW4388550445

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.