Evidence map›Paper›PMID 37950884›Full record

Trial reportThe Journal of infectious diseases2024

Influenza A(H3N2) Antibody Responses to Standard-Dose Versus Enhanced Influenza Vaccine Immunogenicity in Older Adults and Prior Season's Vaccine Status.

Shuyi Zhong, Tiffany W Y Ng, Danuta M Skowronski, A Danielle Iuliano, Nancy H L Leung, Ranawaka A P M Perera, Faith Ho, Vicky J Fang, Yat Hung Tam, Dennis K M Ip and 7 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Enhanced Influenza Vaccines Extend A(H3N2) Antibody Reactivity in Older Adults but Prior Vaccination Effects Persist.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025
    Trial
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Article
  7. Influenza vaccination in older people: a geriatrician's perspective.Aging clinical and experimental research · 2025
    Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Shuyi ZhongWorld Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region, China.
Tiffany W Y NgWorld Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region, China.
Danuta M SkowronskiEpidemiology Services, British Columbia Centre for Disease Control, Vancouver, Canada.
A Danielle IulianoInfluenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Nancy H L LeungWorld Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region, China.
Ranawaka A P M PereraWorld Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region, China.
Faith HoWorld Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region, China.
Vicky J FangWorld Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region, China.
Yat Hung TamWorld Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region, China.
Dennis K M IpWorld Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region, China.
Fiona G HaversDivision of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Alicia M FryInfluenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Eduardo Aziz-BaumgartnerInfluenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Ian G BarrWorld Health Organization Collaborating Centre for Reference and Research on Influenza, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
Malik PeirisWorld Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region, China.
Mark G ThompsonInfluenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Benjamin J CowlingWorld Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region, China.ORCID 0000-0002-6297-7154

Funding

NIAID Centers of Excellence for Influenza Research and Response: Universal Influenza Vaccine Research Activities75N93021C00016 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI WEBBY, RICHARD · 2021 to 2025
$91.4M
Research on the Epidemiology, Vaccine Effectiveness and Treatment of Influenza and Other Respiratory Viruses in Southeast Asia and the Western PacificU01IP001064 · IP · UNIVERSITY OF HONG KONG · PI COWLING, BENJAMIN JOHN · 2016 to 2020
$10.4M
CDC HHS IP001064-02HHS 75N93021C00016National Institute of Allergy and Infectious DiseasesNCIRD CDC HHS U01 IP001064NIAID NIH HHS 75N93021C00016NIH HHSResearch Grants Council T11-712/19-N
6 · The paper itself

Abstract

backgroundAnnual influenza vaccination is recommended for older adults but repeated vaccination with standard-dose influenza vaccine has been linked to reduced immunogenicity and effectiveness, especially against A(H3N2) viruses.

methodsCommunity-dwelling Hong Kong adults aged 65-82 years were randomly allocated to receive 2017-2018 standard-dose quadrivalent, MF59-adjuvanted trivalent, high-dose trivalent, and recombinant-HA quadrivalent vaccination. Antibody response to unchanged A(H3N2) vaccine antigen was compared among participants with and without self-reported prior year (2016-2017) standard-dose vaccination.

resultsMean fold rise (MFR) in antibody titers from day 0 to day 30 by hemagglutination inhibition and virus microneutralization assays were lower among 2017-2018 standard-dose and enhanced vaccine recipients with (range, 1.7-3.0) versus without (range, 4.3-14.3) prior 2016-2017 vaccination. MFR was significantly reduced by about one-half to four-fifths for previously vaccinated recipients of standard-dose and all 3 enhanced vaccines (β range, .21-.48). Among prior-year vaccinated older adults, enhanced vaccines induced higher 1.43 to 2.39-fold geometric mean titers and 1.28 to 1.74-fold MFR versus standard-dose vaccine by microneutralization assay.

conclusionsIn the context of unchanged A(H3N2) vaccine strain, prior-year vaccination was associated with reduced antibody response among both standard-dose and enhanced influenza vaccine recipients. Enhanced vaccines improved antibody response among older adults with prior-year standard-dose vaccination.

Indexed as

Antibodies, ViralHemagglutination Inhibition TestsInfluenza A Virus, H3N2 SubtypeInfluenza, HumanInfluenza VaccinesAgedAged, 80 and overAntibody FormationFemaleHong KongHumansImmunogenicity, VaccineMaleSqualeneVaccinationAntibodies, ViralInfluenza VaccinesSqualeneantibody responseinfluenza vaccineolder adultsrepeated vaccination

Identifiers

PMID37950884
PMCPMC11095559

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.