SynthesisCell reports2023
Integrative single-cell meta-analysis reveals disease-relevant vascular cell states and markers in human atherosclerosis.
Open access · goldAbstract readMeta-Analysis
In one paragraph
Synthesis in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.
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83citing papers in PubMed
12.9field-weighted citation impact, top 1% of its field
What it found
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Who cites it
83 citing papers in PubMed, 84 citations in OpenAlex.
- Cell-Surface Signatures and Targets of Modulated Vascular Smooth Muscle Cells in Atherosclerosis: From State Identification to Precision Intervention.Journal of cardiovascular development and disease · 2026Review
- Morphogen-guided neocortical organoids with anteroposterior areal identity.Cell stem cell · 2026Article
- Atherosclerotic Cell Fates: A Single-Cell View of ER Stress.Journal of cardiovascular development and disease · 2026Review
- Coordinated inflammatory macrophage and vascular smooth muscle cell remodeling signatures in human atherosclerosis: An integrative single-cell and bulk transcriptomic analysis.Journal of cell communication and signaling · 2026Article
- Multi-omics-driven precision medicine.iMeta · 2026Review
- Therapeutic Target Mapping to Advance Drug Repurposing for Cardiovascular Disease: A Perspective from an Explanted Heart Biobank.Journal of personalized medicine · 2026Review
- Transcriptomic, Specific Marker, and Pathway Analysis of Smooth Muscle Cell Foam Cells Relative to Macrophage Foam Cells in Human Atherosclerosis.bioRxiv : the preprint server for biology · 2026Article
- Single-cell transcriptomics uncovers endothelial progenitor-like remodelling driving human coronary atherosclerosis progression.Nature cell biology · 2026Article
- Endothelial cells modulate immune cell responses during atherosclerosis.Trends in immunology · 2026Review
- AI-Guided Long Non-Coding RNA Target Discovery for Precision Medicine: Integrating GWAS, Multi-Omics, Experimental Validation, and RNA Therapeutics.Biomedicines · 2026Review
- A rare pre-existing progenitor-like Primed SMC compartment is the dominant inferred source of SMC-derived cellularity in vascular injury and atherosclerosis.bioRxiv : the preprint server for biology · 2026Article
- Spatial transcriptomics reveals a key role of fibroblast-like vascular smooth muscle cells in human atherosclerotic cell crosstalk and stability.European heart journal · 2026Article
- Multi-layer network biology combined with single-cell evidence reveals core regulatory nodes in atherosclerotic plaques and potential drug-targeting directions.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Immunothrombotic Cell-Cell Communication Networks in Coronary Atherosclerosis: Critical Insights from Single-Cell and Spatial Systems Biology.International journal of molecular sciences · 2026Review
- Atherosclerosis Profiling Reveals BHLHE40 as a Candidate Modulator of VSMC.Circulation research · 2026Article
- The Complex Role of Methylation in Regulating Vascular Smooth Muscle Cell Phenotypic States in Vascular Remodeling and Atherosclerosis.Biomolecules · 2026Review
- FOXC1 Controls Smooth Muscle Cell Differentiation and Plasticity in Vascular Disease.JACC. Basic to translational science · 2026Article
- Proteogenomic Analysis of Coronary Artery Calcification in Human Populations.Arteriosclerosis, thrombosis, and vascular biology · 2026Article
- Multimodal atlas of human atherosclerosis links granular vascular cell states to coronary artery disease risk.medRxiv : the preprint server for health sciences · 2026Article
- CD8Nature reviews. Cardiology · 2026Review
23 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors at 9 institutions in 5 countries.
Jose Verdezoto MosqueraDepartment of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22908, USA; Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA.
Gaëlle AugusteCenter for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA.
Doris WongDepartment of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22908, USA; Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA.
Adam W TurnerCenter for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA.
Chani J HodonskyCenter for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA.
Astrid Catalina Alvarez-YelaDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA.
Yipei SongCenter for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA; Department of Computer Engineering, University of Virginia, Charlottesville, VA 22908, USA.
Qi ChengCVPath Institute, Gaithersburg, MD 20878, USA.
Christian L Lino CardenasCardiovascular Research Center, Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA.
Konstantinos TheofilatosKing's British Heart Foundation Centre, King's College London, London WC2R 2LS, UK.
Maxime BosDepartment of Epidemiology, Erasmus University Medical Center, 3000 CA Rotterdam, the Netherlands.
Maryam KavousiDepartment of Epidemiology, Erasmus University Medical Center, 3000 CA Rotterdam, the Netherlands.
Patricia A PeyserDepartment of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI 48019, USA.
Manuel MayrKing's British Heart Foundation Centre, King's College London, London WC2R 2LS, UK; National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.
Jason C KovacicCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia; St. Vincent's Clinical School, University of New South Wales, Sydney, NSW 2052, Australia.
Johan L M BjörkegrenDepartment of Genetics and Genomic Sciences, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Medicine, Karolinska Institutet, 141 52 Huddinge, Sweden.
Rajeev MalhotraCardiovascular Research Center, Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA.
P Todd StukenbergDepartment of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22908, USA.
Aloke V FinnCVPath Institute, Gaithersburg, MD 20878, USA.
Sander W van der LaanCentral Diagnostics Laboratory, Division Laboratories, Pharmacy, and Biomedical Genetics, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, the Netherlands.
Chongzhi ZangDepartment of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22908, USA; Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA; Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA; Department of Public Health Sciences, University of Virginia, Charlottesville, VA 22908, USA.
Nathan C SheffieldDepartment of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22908, USA; Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA; Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA; Department of Public Health Sciences, University of Virginia, Charlottesville, VA 22908, USA.
Clint L MillerDepartment of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22908, USA; Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA; Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA; Department of Public Health Sciences, University of Virginia, Charlottesville, VA 22908, USA. Electronic address: clintm@virginia.edu.
University of Virginia · USCVPath Institute · USErasmus MC · NLHarvard University · USKing's College London · GBKarolinska Institutet · SEUniversity of Michigan · USUtrecht University · NLVictor Chang Cardiac Research Institute · AU
Funding
Multimodal genetic regulatory architecture of coronary artery diseaseR01HL148239 · NHLBI · UNIVERSITY OF VIRGINIA · PI Clint L Miller · 2019 to 2026
$4.2MThe Role of Histone Deacetylase 9 in Vascular CalcificationR01HL142809 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI MALHOTRA, RAJEEV · 2018 to 2022
$4.0MTherapeutic Mechanisms of Cardiac Progenitors in Ischemic CardiomyopathyR01HL135093 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI FISH, KENNETH MICHAEL, KOVACIC, JASON CIRIL · 2017 to 2020
$3.4MIntegrative computational models for functional epigenomics and transcriptional regulationR35GM133712 · NIGMS · UNIVERSITY OF VIRGINIA · PI Chongzhi Zang · 2019 to 2026
$3.4MToward Diagnostics and Therapies of Molecular Subcategories of CADR01HL125863 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BJORKEGREN, JOHAN M · 2015 to 2018
$3.2MIL1beta signaling in SMCpromotes beneficial changes in late stage atherosclerotic lesion pathogenesisR01HL141425 · NHLBI · UNIVERSITY OF VIRGINIA · PI OWENS, GARY K · 2019 to 2022
$3.1MUnderstanding the Molecular Mechanisms of Fibromuscular DysplasiaR01HL148167 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KADIAN-DODOV, DANIELLA, KOVACIC, JASON CIRIL · 2020 to 2023
$2.8MCharacterization of Functional Iron Deficiency and Repletion in Heart Failure with Preserved Ejection FractionR01HL159514 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI LEWIS, GREGORY DYER, MALHOTRA, RAJEEV · 2021 to 2024
$2.5MFunctional genomics investigation of pleiotropic vascular disease lociR01HL164577 · NHLBI · UNIVERSITY OF VIRGINIA · PI MILLER, CLINT L · 2022 to 2025
$2.3MToward Therapeutic Manipulation of Endothelial to Mesenchymal TransitionR01HL130423 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ISHIKAWA, KIYOTAKE, KOVACIC, JASON CIRIL · 2016 to 2020
$2.1MNovel molecular mechanisms of vascular smooth muscle cell-mediated large and small artery calcificationK01HL164687 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Christian Lacks Lino Cardenas · 2022 to 2026
$808kBritish Heart Foundation CH/16/3/32406British Heart Foundation RG/F/21/110053NHLBI NIH HHS K01 HL164687NHLBI NIH HHS R01 HL125863NHLBI NIH HHS R01 HL130423NHLBI NIH HHS R01 HL135093NHLBI NIH HHS R01 HL141425NHLBI NIH HHS R01 HL142809NHLBI NIH HHS R01 HL148167NHLBI NIH HHS R01 HL148239NHLBI NIH HHS R01 HL159514NHLBI NIH HHS R01 HL164577NIGMS NIH HHS R35 GM133712
Abstract
Coronary artery disease (CAD) is characterized by atherosclerotic plaque formation in the arterial wall. CAD progression involves complex interactions and phenotypic plasticity among vascular and immune cell lineages. Single-cell RNA-seq (scRNA-seq) studies have highlighted lineage-specific transcriptomic signatures, but human cell phenotypes remain controversial. Here, we perform an integrated meta-analysis of 22 scRNA-seq libraries to generate a comprehensive map of human atherosclerosis with 118,578 cells. Besides characterizing granular cell-type diversity and communication, we leverage this atlas to provide insights into smooth muscle cell (SMC) modulation. We integrate genome-wide association study data and uncover a critical role for modulated SMC phenotypes in CAD, myocardial infarction, and coronary calcification. Finally, we identify fibromyocyte/fibrochondrogenic SMC markers (LTBP1 and CRTAC1) as proxies of atherosclerosis progression and validate these through omics and spatial imaging analyses. Altogether, we create a unified atlas of human atherosclerosis informing cell state-specific mechanistic and translational studies of cardiovascular diseases.
Indexed as
AtherosclerosisCoronary Artery DiseaseMyocardial InfarctionPlaque, AtheroscleroticCalcium-Binding ProteinsGenome-Wide Association StudyHumansMyocytes, Smooth MuscleCalcium-Binding ProteinsCRTAC1 protein, humanatherosclerosiscoronary artery diseaseCP: Genomicsgenome-wide association studiesintegration analysessingle cell RNA-seqsmooth muscle cells
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