ArticleCell reports2023
Brainstem fMRI signaling of surprise across different types of deviant stimuli.
Article in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Evidence for domain-general arousal from semantic and neuroimaging meta-analyses reconciles opposing views on arousal.Proceedings of the National Academy of Sciences of the United States of America · 2025Pooled it
- The impact of transcutaneous vagus nerve stimulation on anterior cingulate cortex activity in a cognitive control task.Psychophysiology · 2025Trial
- A large-scale heterogeneous 3D magnetic resonance brain imaging dataset for self-supervised learning.Scientific data · 2026Article
- Arousal shapes motivation: an integrative framework for understanding motivational deficits.Translational psychiatry · 2026Review
- Evaluating the quality of brainstem ROI registration using structural and diffusion MRI.Frontiers in neuroscience · 2026Article
- Article
- Shared subcortical arousal systems across sensory modalities during transient modulation of attention.NeuroImage · 2025Article
- Subcortical nuclei of the human ascending arousal system encode anticipated reward but do not predict subsequent memory.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Effort drives saccade selection.eLife · 2025Article
- Violated predictions enhance the representational fidelity of visual features in perception.Journal of vision · 2025Article
- Brain network dynamics predict moments of surprise across contexts.Nature human behaviour · 2025Article
- Multimodal evidence challenges the effectiveness of probabilistic cueing for establishing sensory expectations.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Parallel mechanisms signal a hierarchy of sequence structure violations in the auditory cortex.eLife · 2024Article
- Task-irrelevant stimuli reliably boost phasic pupil-linked arousal but do not affect decision formation.Scientific reports · 2024Article
- Shared subcortical arousal systems across sensory modalities during transient modulation of attention.bioRxiv : the preprint server for biology · 2024Article
- Toward a computational role for locus coeruleus/norepinephrine arousal systems.Current opinion in behavioral sciences · 2024Article
- Atrophy links lower novelty-related locus coeruleus connectivity to cognitive decline in preclinical AD.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Detection of deviant stimuli is crucial to orient and adapt our behavior. Previous work shows that deviant stimuli elicit phasic activation of the locus coeruleus (LC), which releases noradrenaline and controls central arousal. However, it is unclear whether the detection of behaviorally relevant deviant stimuli selectively triggers LC responses or other neuromodulatory systems (dopamine, serotonin, and acetylcholine). We combine human functional MRI (fMRI) recordings optimized for brainstem imaging with pupillometry to perform a mapping of deviant-related responses in subcortical structures. Participants have to detect deviant items in a "local-global" paradigm that distinguishes between deviance based on the stimulus probability and the sequence structure. fMRI responses to deviant stimuli are distributed in many cortical areas. Both types of deviance elicit responses in the pupil, LC, and other neuromodulatory systems. Our results reveal that the detection of task-relevant deviant items recruits the same multiple subcortical systems across computationally different types of deviance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.