Evidence map›Paper›PMID 37950834›Full record

ArticleFish physiology and biochemistry2023

Environmentally relevant concentrations of tris (2-chloroethyl) phosphate (TCEP) induce hepatotoxicity in zebrafish (Danio rerio): a whole life-cycle assessment.

Fengxiao Hu, Wen Li, Hongkai Wang, Hangke Peng, Jiabo He, Jieyu Ding, Weini Zhang

Abstract read
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In one paragraph

Article in Fish physiology and biochemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Fengxiao HuKey Laboratory of Marine Biotechnology of Fujian Province, College of Marine Sciences, Institute of Oceanology, Fujian Agriculture and Forestry University, Fuzhou, 350002, China. hufengxiao@fafu.edu.cn.
Wen LiKey Laboratory of Marine Biotechnology of Fujian Province, College of Marine Sciences, Institute of Oceanology, Fujian Agriculture and Forestry University, Fuzhou, 350002, China.
Hongkai WangKey Laboratory of Marine Biotechnology of Fujian Province, College of Marine Sciences, Institute of Oceanology, Fujian Agriculture and Forestry University, Fuzhou, 350002, China.
Hangke PengKey Laboratory of Marine Biotechnology of Fujian Province, College of Marine Sciences, Institute of Oceanology, Fujian Agriculture and Forestry University, Fuzhou, 350002, China.
Jiabo HeKey Laboratory of Marine Biotechnology of Fujian Province, College of Marine Sciences, Institute of Oceanology, Fujian Agriculture and Forestry University, Fuzhou, 350002, China.
Jieyu DingKey Laboratory of Marine Biotechnology of Fujian Province, College of Marine Sciences, Institute of Oceanology, Fujian Agriculture and Forestry University, Fuzhou, 350002, China.
Weini ZhangKey Laboratory of Marine Biotechnology of Fujian Province, College of Marine Sciences, Institute of Oceanology, Fujian Agriculture and Forestry University, Fuzhou, 350002, China.
Fujian Agriculture and Forestry University · CN

Funding

National College Students Innovation and Entrepreneurship Training Program 202310389025
6 · The paper itself

Abstract

Tris (2-chloroethyl) phosphate (TCEP), a typical organophosphate flame retardant, is of increasingly great concern considering their ubiquitous presence in aquatic environments and potential ecotoxicity. The present work was aimed to investigate the potential growth inhibition and hepatic stress induced by whole life-cycle exposure to TCEP (0.8, 4, 20 and 100 μg/L) in zebrafish. The results revealed that the body length, body mass and hepatic-somatic index (HSI) of zebrafish were significantly declined after exposure to TCEP for 120 days. GPx activity and GSH content were increased in the liver of zebrafish treated with low concentrations (0.8 and 4 μg/L) of TCEP, while exposure to high concentrations (20 and 100 μg/L) of TCEP reduced antioxidative capacity and elevated lipid peroxidation (LPO) levels. Gene transcription analysis demonstrated that the mRNA levels of nrf2 were altered in a similar manner to the transcription of the downstream genes nqo1 and hmox1, suggesting that Nrf2-Keap1 pathway mediated TCEP-induced oxidative stress in zebrafish liver. In addition, TCEP exposure might alleviate inflammatory response through down-regulating transcription of inflammatory cytokines (il-1β, il-6 and inos), and induce apoptosis via activating the p53-Bax pathway. Moreover, whole life-cycle exposure to TCEP caused a series of histopathological anomalies in zebrafish liver. Overall, our results revealed that lifetime exposure to environmentally relevant concentrations of TCEP could result in growth retardation and induce significant hepatotoxicity in zebrafish.

Indexed as

Chemical and Drug Induced Liver InjuryFlame RetardantsAnimalsKelch-Like ECH-Associated Protein 1NF-E2-Related Factor 2OrganophosphatesPhosphatesPhosphinesZebrafishFlame RetardantsKelch-Like ECH-Associated Protein 1NF-E2-Related Factor 2OrganophosphatesPhosphatesPhosphinestris(2-carboxyethyl)phosphinetris(chloroethyl)phosphateApoptosisHistological changesInflammatory responseOxidative stressTCEPZebrafish

Identifiers

PMID37950834
OpenAlexW4388593497

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.