Evidence map›Paper›PMID 37950820›Full record

ArticleArchives of microbiology2023

Antinociceptive and anti-inflammatory properties of α-D-mannan from the yeast Kluyveromyces marxianus: evidence for a role in interleukin-6 inhibition.

Renata Freitas de A T Calumby, Flávia Oliveira de Lima, Gildomar Lima Valasques Junior, Jener David Gonçalves Santos, Pedro Felipe Pereira Chaves, Lucimara Mach Côrtes Cordeiro, Cristiane Flora Villarreal, Milena Botelho Pereira Soares, Elisangela Fabiana Boffo, Sandra Aparecida de Assis

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In one paragraph

Article in Archives of microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.6field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Renata Freitas de A T CalumbyHealth Department, State University of Feira de Santana, Av. Transnordestina s/n, Feira de Santana, Bahia, 44036-900, Brazil.
Flávia Oliveira de LimaHealth Department, State University of Feira de Santana, Av. Transnordestina s/n, Feira de Santana, Bahia, 44036-900, Brazil.
Gildomar Lima Valasques JuniorHealth Department, State University of Feira de Santana, Av. Transnordestina s/n, Feira de Santana, Bahia, 44036-900, Brazil.
Jener David Gonçalves SantosUniversity Veterinary Hospital, Federal University of Agreste of Pernambuco, Garanhuns, PE, 55292-278, Brazil.
Pedro Felipe Pereira ChavesBiochemistry and Molecular Biology Department, Federal University of Paraná, CP 19.046, Curitiba, PR, CEP 81531-980, Brazil.
Lucimara Mach Côrtes CordeiroBiochemistry and Molecular Biology Department, Federal University of Paraná, CP 19.046, Curitiba, PR, CEP 81531-980, Brazil.
Cristiane Flora VillarrealGonçalo Moniz Research Center (CPqGM), Fundação Oswaldo Cruz, Rua Waldemar Falcão 121, Salvador, BA, 40296-710, Brazil.
Milena Botelho Pereira SoaresGonçalo Moniz Research Center (CPqGM), Fundação Oswaldo Cruz, Rua Waldemar Falcão 121, Salvador, BA, 40296-710, Brazil.
Elisangela Fabiana BoffoChemistry Institute, Federal University of Bahia, Barão de Jeremoabo s/n, Salvador, Bahia, 40170-290, Brazil.
Sandra Aparecida de AssisHealth Department, State University of Feira de Santana, Av. Transnordestina s/n, Feira de Santana, Bahia, 44036-900, Brazil. sandraassis@uefs.br.
Universidade Estadual de Feira de Santana · BRFundação Oswaldo Cruz · BRUniversidade Federal do Paraná · BRUniversidade Federal da Bahia · BRUniversidade Federal de Pernambuco · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The management of inflammatory states typically involves non-steroidal anti-inflammatory drugs (NSAIDs) and opiates. Understanding the mechanisms underlying the processing of nociceptive information from potential alternatives such as some polysaccharides may enable new and meaningful therapeutic approaches. In this study, α-D-mannan isolated from the Kluyveromyces marxianus cell wall produced antinociceptive effects in models of inflammatory pain (formalin and complete Freund's adjuvant tests). Furthermore, α-D-mannan reduced paw edema and interleukin-6 (IL-6) production after carrageenan-induced inflammation. The polysaccharide α-D-mannan was characterized by gas chromatography-mass spectrometry, methylation analysis, and spectroscopic techniques. Moreover, the Doehlert experimental design was applied to find the optimal conditions for biomass production, with the best conditions being 10.8 g/L and 117 h for the glucose concentration and the fermentation time, respectively. These results indicate that α-D-mannan from K. marxianus exerts anti-inflammatory and antinociceptive effects in mice, possibly via a mechanism dependent on the inhibition of IL-6 production.

Indexed as

AnalgesicsInterleukin-6AnimalsAnti-Inflammatory AgentsKluyveromycesMannansMicePolysaccharidesAnalgesicsAnti-Inflammatory AgentsInterleukin-6MannansPolysaccharidesAnti-inflammatoryBiological activityInflammationKluyveromyces marxianusPainPolysaccharide

Identifiers

PMID37950820
OpenAlexW4388594021

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.