Evidence map›Paper›PMID 37950730›Full record

ArticleAging2023

D-galactose causes sinoatrial node dysfunction: from phenotype to mechanism.

Heng Zhang, Chen Chen, Yue Liu, Wei Chen, Jing Qi, Yue Xu, Lu Ren, Guanlin Yang, Dongyu Min, Zhuang Liu and 4 more

Open access · hybridAbstract read
In one paragraph

Article in Aging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 1 country.

Heng ZhangShandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China.
Chen ChenShandong University of Traditional Chinese Medicine, Jinan 250355, China.
Yue LiuShenyang Medical College, Shenyang 110034, China.
Wei ChenAffiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 116600, China.
Jing QiAffiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 116600, China.
Yue XuAffiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 116600, China.
Lu RenAffiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 116600, China.
Guanlin YangAffiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 116600, China.
Dongyu MinAffiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 116600, China.
Zhuang LiuAffiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 116600, China.
Xintong CaiAffiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 116600, China.
Miao HaoAffiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 116600, China.
Guanzhen XuAffiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 116600, China.
Ping HouAffiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 116600, China.
Liaoning University of Traditional Chinese Medicine · CNAffiliated Hospital of Liaoning University of Traditional Chinese Medicine · CNShandong Provincial Hospital · CNShandong University of Traditional Chinese Medicine · CNShenyang Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With the population aging, age-related sinoatrial node dysfunction (SND) has been on the rise. Sinoatrial node (SAN) degeneration is an important factor for the age-related SND development. However, there is no suitable animal modeling method in this field. Here, we investigated whether D-galactose could induce SAN degeneration and explored the associated mechanism.

Indexed as

GalactoseSinoatrial NodeAnimalsMiceMice, Inbred C57BLMyocytes, CardiacPhenotypeGalactoseD-galactoseion channels dysfunctionoxidative stresssenescencesinoatrial node dysfunction

Identifiers

PMID37950730
PMCPMC10683603
OpenAlexW4388540812

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.