Evidence map›Paper›PMID 37950709›Full record

ArticleJournal of neurotrauma2024

Neurological Effects of Repeated Blast Exposure in Special Operations Personnel.

James R Stone, Brian B Avants, Nicholas J Tustison, Jessica Gill, Elisabeth A Wilde, Kiel D Neumann, Leslie A Gladney, Madison O Kilgore, F Bowling, Christopher M Wilson and 5 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of neurotrauma, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 26 citations in OpenAlex.

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  14. Impact of repeated blast exposure on active-duty United States Special Operations Forces.Proceedings of the National Academy of Sciences of the United States of America · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 1 country.

James R StoneDepartment of Radiology and Medical Imaging, University of Virginia, Charlottesville, Virginia, USA.
Brian B AvantsDepartment of Radiology and Medical Imaging, University of Virginia, Charlottesville, Virginia, USA.
Nicholas J TustisonDepartment of Radiology and Medical Imaging, University of Virginia, Charlottesville, Virginia, USA.
Jessica GillSchool of Nursing, Johns Hopkins University, Baltimore, Maryland, USA.
Elisabeth A WildeDepartment of Neurology, University of Utah, Salt Lake City, Utah, USA.
Kiel D NeumannMolecular Imaging Research Hub, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Leslie A GladneyDepartment of Radiology and Medical Imaging, University of Virginia, Charlottesville, Virginia, USA.
Madison O KilgoreDepartment of Radiology and Medical Imaging, University of Virginia, Charlottesville, Virginia, USA.
F BowlingU.S. Special Operations Command, Tampa, Florida, USA.
Christopher M WilsonU.S. Special Operations Command, Tampa, Florida, USA.
John F DetroU.S. Special Operations Command, Tampa, Florida, USA.
Heather G BelangerDepartments of Psychiatry and Behavioral Neurosciences, and Psychology, University of South Florida, Tampa, Florida, USA.
Katryna DearyU.S. Special Operations Command, Tampa, Florida, USA.
Hans LinsenbardtNaval Medical Research Command, Silver Spring, Maryland, USA.
Stephen T AhlersOperational and Undersea Medicine Directorate, Naval Medical Research Command, Silver Spring, Maryland, USA.
University of Virginia · USJoint Special Operations University · USNaval Medical Research Command · USJohns Hopkins University · USSt. Jude Children's Research Hospital · USUniversity of South Florida · USUniversity of Utah · US

Funding

Novel imaging agents of oxidative stress in the pathophysiology of the central nervous systemR01EB028338 · NIBIB · UNIVERSITY OF VIRGINIA · PI NEUMANN, KIEL · 2020 to 2020
$2.1M
NIBIB NIH HHS R01 EB028338
6 · The paper itself

Abstract

Exposure to blast overpressure has been a pervasive feature of combat-related injuries. Studies exploring the neurological correlates of repeated low-level blast exposure in career "breachers" demonstrated higher levels of tumor necrosis factor alpha (TNFα) and interleukin (IL)-6 and decreases in IL-10 within brain-derived extracellular vesicles (BDEVs). The current pilot study was initiated in partnership with the U.S. Special Operations Command (USSOCOM) to explore whether neuroinflammation is seen within special operators with prior blast exposure. Data were analyzed from 18 service members (SMs), inclusive of 9 blast-exposed special operators with an extensive career history of repeated blast exposures and 9 controls matched by age and duration of service. Neuroinflammation was assessed utilizing positron emission tomography (PET) imaging with [

Indexed as

Blast InjuriesMilitary PersonnelExplosionsHumansInterleukin-6Neuroinflammatory DiseasesPilot ProjectsInterleukin-6militaryneuroimagingneuroinflammationrepeated blast exposureserum biomarker

Identifiers

PMID37950709
PMCPMC11001960
OpenAlexW4388592059

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.