Evidence map›Paper›PMID 37950647›Full record

ArticleJournal of geriatric psychiatry and neurology2024

Depressive Symptoms are Associated With C-Reactive Protein in Older Adults With Obesity.

Henry D Heisey, Clifford Qualls, Dennis T Villareal, Martha Belen Segoviano-Escobar, Maria Liza Duremdes Nava, Jennifer R Gatchel, Mark E Kunik

Abstract read
In one paragraph

Article in Journal of geriatric psychiatry and neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Henry D HeiseyDepartment of Psychiatry, Baylor College of Medicine, Houston, TX, United States.ORCID 0000-0001-8136-2625
Clifford QuallsDepartment of Mathematics and Statistics, University of New Mexico School of Medicine, Albuquerque, NM, United States.
Dennis T VillarealMichael E. DeBakey Veterans Affairs Medical Center, Center for Translational Research on Inflammatory Diseases, Houston, TX, United States.
Martha Belen Segoviano-EscobarMichael E. DeBakey Veterans Affairs Medical Center, Center for Translational Research on Inflammatory Diseases, Houston, TX, United States.
Maria Liza Duremdes NavaMichael E. DeBakey Veterans Affairs Medical Center, Center for Translational Research on Inflammatory Diseases, Houston, TX, United States.
Jennifer R GatchelDepartment of Psychiatry, Baylor College of Medicine, Houston, TX, United States.
Mark E KunikDepartment of Psychiatry, Baylor College of Medicine, Houston, TX, United States.

Funding

DOES LIFESTYLE INTERVENTION IN OBESE OLDER ADULTS IMPROVE BONE QUALITY?R01DK109950 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI VILLAREAL, DENNIS T. · 2017 to 2022
$3.4M
Lifestyle Intervention plus Metformin to Treat Frailty in Older Veterans with ObesityI01CX002161 · VA · MICHAEL E DEBAKEY VA MEDICAL CENTER · PI DENNIS T. VILLAREAL · 2021 to 2026
–
CSRD VA I01 CX002161NIDDK NIH HHS R01 DK109950
6 · The paper itself

Abstract

objectivesTo test the hypothesis that depressive symptoms vary with high-sensitivity C-reactive protein (hs-CRP), among older adults with obesity.

methodsThis was a cross-sectional, secondary analysis of baseline data from two related lifestyle intervention trials. The study sample comprises 148 consecutively recruited, community-dwelling older adults (age >=65 years) without severe psychiatric illness and with body mass index >=30 kg/m

resultsSample mean GDS score was 2.7 (SD 3.0, range 0 - 14). A significant multivariate model of GDS scores (R

conclusionsIn older adults with obese BMI, male sex and higher hs-CRP are associated with depression, even in a group with relatively minimal depressive symptoms. Hs-CRP may offer clinical utility as a biomarker for depression among older adults with obese BMI, even among those with non-severe psychiatric symptomatology.

Indexed as

C-Reactive ProteinDepressionObesityAgedAged, 80 and overBiomarkersBody Mass IndexCross-Sectional StudiesFemaleHumansMaleSex FactorsBiomarkersC-Reactive Proteindepressionelderlygeriatric psychiatrygeriatricsmental healthneurochemistry

Identifiers

PMID37950647
PMCPMC11087374

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.