ArticleBMC musculoskeletal disorders2023
Impact of central sensitization on pain, disability and psychological distress in patients with knee osteoarthritis and chronic low back pain.
Article in BMC musculoskeletal disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Association between pain intensity and body composition in adults with chronic non-specific low back pain: A systematic review and meta-analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025Pooled it
- Brain functional changes following spinal manipulation therapy in patients with lumbar disc herniation and chronic low back pain: a scoping review.Frontiers in neurology · 2025Pooled it
- Efficacy of home-based low-level laser therapy in patients with low back pain: a double-blinded randomized controlled trial.Lasers in medical science · 2026Trial
- The relationship between neck and body awareness, pain, and proprioception with central sensitization in patients with chronic nonspecific neck pain.BMC musculoskeletal disorders · 2026Trial
- Effects of Acupuncture-Combined Tuina on Patients With Knee Osteoarthritis: Protocol for a Randomized Controlled Trial.JMIR research protocols · 2026Trial
- Association between central sensitization-related symptoms and pressure pain thresholds at local and remote sites in patients with knee osteoarthritis.International orthopaedics · 2026Article
- Psychosocial and Functional Determinants of Central Sensitisation in Patients with Behçet's Disease: A Cross-Sectional Study.Mediterranean journal of rheumatology · 2026Article
- Multi-Trajectories of Sleep Disturbance and Depressive Symptoms and Incident Osteoarthritis: Evidence From the English Longitudinal Study of Ageing.Brain and behavior · 2026Article
- Meditations on Methodological Issues in Clinical Investigations of "Central Sensitization" (Jonah XII).Journal of clinical medicine · 2026Article
- Beyond Structural Pathology: Central Sensitization and Chronic Pain with Reference to Lumbar Disc Herniation-A Narrative Review.Brain sciences · 2026Review
- Phenomenological exploration of perceptions, experiences, facilitators, and inhibitors in patients with knee osteoarthritis during physiotherapy rehabilitation in a low- and middle-income country.BMC musculoskeletal disorders · 2026Article
- Exploring the relationships between multisite musculoskeletal pain, pain characteristics, and physical function: a cross-sectional analysis.BMC musculoskeletal disorders · 2026Article
- Central sensitization as a predictor of short-term postoperative outcomes in lumbar spinal stenosis: a prospective observational study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Observational
- Central Sensitization as a Marker of Cognitive and Emotional Vulnerability in Chronic Low Back Pain.Brain sciences · 2026Article
- Impact of Mindfulness-Based Cognitive Therapy on Trajectory of Mood States in Patients with Chronic Pain: A Retrospective Observational Study of Within-Session Evaluations.Journal of clinical medicine · 2026Article
- Does the predominance of central sensitization alter the effect of balneotherapy combined with conventional physical therapy in patients with chronic low back and knee pain?International journal of biometeorology · 2026Observational
- Development of a clinical prediction model for chronic post-surgical shoulder pain following arthroscopic rotator cuff repair: A prospective cohort study.Shoulder & elbow · 2026Article
- Feasibility and Preliminary Effects of Adding Percutaneous Electrical Nerve Stimulation to a Pain Education and Exercise Program in Patients with Knee Osteoarthritis: A Pilot Randomized Controlled Trial.Journal of clinical medicine · 2026Article
- Sensorimotor dysfunction and altered pain sensitivity in early hip osteoarthritis: associations with hip proprioception and balance impairment.Frontiers in medicine · 2026Article
- Pain catastrophizing and its association with functional disability and psychological distress in patients with chronic low back pain: a retrospective study.Frontiers in medicine · 2026Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCentral sensitization (CS) is becoming increasingly recognized as a significant factor in many chronic pain conditions, including knee osteoarthritis (KOA) and chronic low back pain (CLBP). Yet it presently remains unclear how strong is the involvement of CS in KOA and CLBP and which factors are involved in CS in these two chronic disabling diseases.
methodsThis is a cross-sectional study in which included a total of 178 patients with KOA and 118 patients with CLBP. Inclusion criteria for eligible participants for the KOA group were a confirmed diagnosis of KOA according to the American College of Rheumatology criteria, and for the CLBP group a chronic low back pain for more than 3 months. Subjects were excluded if they presented with a diagnosed psychiatric disorder or if they lacked the capacity to provide informed consent, understand study questionnaires or perform physical performance tests. In each group, were assessed; CS-related symptoms using the Central Sentization Inventory (CSI); demographic and clinical characteristics such as disease duration, pain intensity on a visual analog scale, self-reported function using the Lequesne index for KOA patients and the Oswestry Disability index for CLBP patients, and physical performance with the 6 minutes' walk test; as well as psychosocial risk factors using the Patient Health Questionnaire for depression (PHQ-9), the Generalized Anxiety Disorder (GAD-7) and the Pain Catastrophizing Scale (PCS).
resultsCSI scores significantly correlated with pain intensity and disability in KOA and CLBP patients, and were highly correlated with self-reported symptoms of depression, anxiety and pain catastrophizing. Depression significantly predicted the CSI score in both groups.
conclusionThese findings provide further evidence for the impact of CS on pain, function and physical performance in KOA and CLBP patients. Psychosocial symptoms such as pain catastrophizing, anxiety and depression should also be considered as they are also associated with CS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.