Evidence map›Paper›PMID 37950082›Full record

ArticleEuropean radiology2024

Bronchiectasis is associated with lower lung function in lung cancer screening participants.

Anastasia K A L Kwee, Bart Luijk, Pim A de Jong, Harry J M Groen, Joachim G J V Aerts, Jean-Paul Charbonnier, Rozemarijn Vliegenthart, Firdaus A A Mohamed Hoesein

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Article in European radiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Is work overload associated with diagnostic errors onEuropean journal of nuclear medicine and molecular imaging · 2024
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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Anastasia K A L KweeDepartment of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands. A.k.a.l.kwee-2@umcutrecht.nl.ORCID http://orcid.org/0000-0002-9056-1885
Bart LuijkDepartment of Pulmonology, University Medical Center Utrecht, Utrecht, The Netherlands.
Pim A de JongDepartment of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands.
Harry J M GroenDepartment of Pulmonology, University Medical Center Groningen, Groningen, The Netherlands.
Joachim G J V AertsDepartment of Pulmonology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Jean-Paul CharbonnierThirona, Nijmegen, The Netherlands.
Rozemarijn VliegenthartDepartment of Radiology, University Medical Center Groningen, Groningen, The Netherlands.
Firdaus A A Mohamed HoeseinDepartment of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectiveBronchiectasis is a frequent incidental finding on chest computed tomography (CT), but its relevance in lung cancer screening is not fully understood. We investigated the association between bronchiectasis and respiratory symptoms, pulmonary function, and emphysema in lung cancer screening participants with and without chronic obstructive pulmonary disease (COPD).

methodsWe included 3260 (ex-)smokers from the Dutch-Belgian lung cancer screening trial (NELSON). Bronchiectasis was scored by chest radiologists. The relationship with pulmonary function (FEV1%predicted, FEV1/FVC), respiratory complaints (cough, dyspnea, wheezing, mucus hypersecretion), and CT-quantified emphysema (15th percentile) was examined with independent t-tests and multivariate regression.

resultsBronchiectasis was present in 5.4% (n = 175/3260). There was no difference in prevalence between subjects with and without COPD (68/1121 [5.9%] vs. 109/2139 [5.1%]; p = .368). COPD subjects with bronchiectasis had a lower FEV1%predicted (76.2% vs. 85.0%; p < .001), lower FEV1/FVC (0.58 vs. 0.62; p < .001), and more emphysema (- 938 HU vs. - 930 HU; p = .001) than COPD subjects without bronchiectasis. In COPD subjects, bronchiectasis was independently associated with a lower FEV1%predicted (B =  - 7.7; CI [- 12.3, - 3.3]), lower FEV1/FVC (B =  - 2.5; CI [- 4.3, - 0.8]), more cough (OR 2.4; CI [1.3, 4.3]), more mucus hypersecretion (OR 1.8; CI [1.0, 3.1]) and more dyspnea (OR 2.3; CI [1.3, 3.9]). In those without COPD (n = 2139), bronchiectasis was associated with more cough, mucus hypersecretion, and wheezing, but not with deteriorating lung function.

conclusionBronchiectasis was present in 5.4% of our lung cancer screening participants and was associated with more respiratory symptoms and, in those with COPD, with lower lung function and more emphysema. CLINICAL RELEVANCE STATEMENT: In a lung cancer screening population, bronchiectasis has a prevalence of 5.4% with a mainly mild severity. This finding is of little clinical relevance unless mild COPD is also present. In those subjects, bronchiectasis was associated with a lower lung function, more respiratory symptoms, and more emphysema. KEY POINTS: • Bronchiectasis was found in 5.4% of lung cancer screening participants, consisting of (ex-)smokers with and without mild COPD. • In those with mild COPD, bronchiectasis was associated with a lower lung function, more respiratory symptoms, and more emphysema. • Incidental findings of mild bronchiectasis are not very relevant in a lung cancer screening population, unless COPD is also present.

Indexed as

BronchiectasisLung NeoplasmsPulmonary Disease, Chronic ObstructiveRespiratory Function TestsTomography, X-Ray ComputedAgedBelgiumEarly Detection of CancerFemaleHumansMaleMiddle AgedNetherlandsPrevalenceBronchiectasisComputed tomographyLung cancer screeningPulmonary function

Identifiers

PMID37950082

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.