Evidence map›Paper›PMID 37950055›Full record

ArticleCommunications biology2023

Repeated multi-domain cognitive training prevents cognitive decline, anxiety and amyloid pathology found in a mouse model of Alzheimer disease.

Jogender Mehla, Scott H Deibel, Hadil Karem, Nancy S Hong, Shakhawat R Hossain, Sean G Lacoursiere, Robert J Sutherland, Majid H Mohajerani, Robert J McDonald

Open access · goldAbstract read
In one paragraph

Article in Communications biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Article
  7. Targeting Ferroptosis/Nrf2 Pathway Ameliorates AlClInternational journal of molecular sciences · 2025
    Article
  8. Article
  9. Article
  10. Cerebral amyloid angiopathy: a narrative review.Frontiers in aging neuroscience · 2025
    Review
  11. Experimental laboratory models as tools for understanding modifiable dementia risk.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Jogender MehlaCanadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada.
Scott H DeibelCanadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada.
Hadil KaremCanadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada.
Nancy S HongCanadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada.
Shakhawat R HossainCanadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada.
Sean G LacoursiereCanadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada.
Robert J SutherlandCanadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada.
Majid H Mohajerani *Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada. mohajerani@uleth.ca.ORCID 0000-0003-0964-2977
Robert J McDonald *Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada. r.mcdonald@uleth.ca.ORCID 0000-0002-7750-7155
University of Lethbridge · CAUniversity of New Brunswick · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Education, occupation, and an active lifestyle, comprising enhanced social, physical, and mental components are associated with improved cognitive functions in aged people and may delay the progression of various neurodegenerative diseases including Alzheimer's disease. To investigate this protective effect, 3-month-old APP

Indexed as

Alzheimer DiseaseCognitive DysfunctionAgedAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAmyloidogenic ProteinsAnimalsAnxietyCognitive TrainingHumansInfantMiceMice, TransgenicAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAmyloidogenic Proteins

Identifiers

PMID37950055
PMCPMC10638434
OpenAlexW4388566369

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.