ArticleEuropean heart journal. Cardiovascular Imaging2024
Echocardiographic estimation of pulmonary artery wedge pressure: invasive derivation, validation, and prognostic association beyond diastolic dysfunction grading.
Article in European heart journal. Cardiovascular Imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Echocardiographic Estimation of Pulmonary Artery Wedge Pressure in Advanced Heart Failure: Head-to-Head Comparison Against Right Heart Catheterization.The international journal of cardiovascular imaging · 2026Article
- The Relationship Between Vortical Flow and Pressure Gradient Reversal in Pulmonary Hypertension-A 4D Analysis of Cardiovascular Magnetic Resonance Flow Imaging.Pulmonary circulation · 2026Article
- Development of a Noninvasive Prediction Score for Post-Capillary Pulmonary Hypertension in a Multi-Ethnic Asian Population.JACC. Asia · 2026Article
- Noninvasive assessment of disproportionate right to left ventricular filling pressure in patients with heart failure.The international journal of cardiovascular imaging · 2026Article
- Noninvasive Evaluation of Ventricular Filling Pressure and Pulmonary Vascular Reserve in Adults With Fontan Circulation.Journal of the American Heart Association · 2025Article
- Mitral annular plane systolic excursion to left atrial volume ratio - a strainless relation with left ventricular filling pressures.The international journal of cardiovascular imaging · 2025Article
- Echocardiography can accurately estimate pulmonary artery wedge pressure without left atrial volume information-diagnostic and prognostic performance.European heart journal. Imaging methods and practice · 2025Article
- Utility of Simultaneous Left Atrial Strain-Volume Relationship During Passive Leg Lift to Identify Elevated Left Ventricular Filling Pressure-A Proof-of-Concept Study.Journal of clinical medicine · 2024Article
- Interpreting Diastolic Dynamics and Evaluation through Echocardiography.Life (Basel, Switzerland) · 2024Review
- Echocardiographic estimation of pulmonary artery wedge pressure: invasive derivation, validation, and prognostic association beyond diastolic dysfunction grading.European heart journal. Cardiovascular Imaging · 2024Article
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Authors and funding
9 authors.
Funding
Abstract
aimsGrading of diastolic function can be useful, but indeterminate classifications are common. We aimed to invasively derive and validate a quantitative echocardiographic estimation of pulmonary artery wedge pressure (PAWP) and to compare its prognostic performance to diastolic dysfunction grading. METHODS AND
resultsEchocardiographic measures were used to derive an estimated PAWP (ePAWP) using multivariable linear regression in patients undergoing right heart catheterization (RHC). Prognostic associations were analysed in the National Echocardiography Database of Australia (NEDA). In patients who had undergone both RHC and echocardiography within 2 h (n = 90), ePAWP was derived using left atrial volume index, mitral peak early velocity (E), and pulmonary vein systolic velocity (S). In a separate external validation cohort (n = 53, simultaneous echocardiography and RHC), ePAWP showed good agreement with invasive PAWP (mean ± standard deviation difference 0.5 ± 5.0 mmHg) and good diagnostic accuracy for estimating PAWP >15 mmHg [area under the curve (95% confidence interval) 0.94 (0.88-1.00)]. Among patients in NEDA [n = 38,856, median (interquartile range) follow-up 4.8 (2.3-8.0) years, 2756 cardiovascular deaths], ePAWP was associated with cardiovascular death even after adjustment for age, sex, and diastolic dysfunction grading [hazard ratio (HR) 1.08 (1.07-1.09) per mmHg] and provided incremental prognostic information to diastolic dysfunction grading (improved C-statistic from 0.65 to 0.68, P < 0.001). Increased ePAWP was associated with worse prognosis across all grades of diastolic function [HR normal, 1.07 (1.06-1.09); indeterminate, 1.08 (1.07-1.09); abnormal, 1.08 (1.07-1.09), P < 0.001 for all].
conclusionEchocardiographic ePAWP is an easily acquired continuous variable with good accuracy that associates with prognosis beyond diastolic dysfunction grading.
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