Evidence map›Paper›PMID 37949765›Full record

ArticleTrends in biochemical sciences2024

Dissecting the biophysics and biology of intrinsically disordered proteins.

Priya R Banerjee, Alex S Holehouse, Richard Kriwacki, Paul Robustelli, Hao Jiang, Alexander I Sobolevsky, Jennifer M Hurley, Joshua T Mendell

Abstract read
In one paragraph

Article in Trends in biochemical sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Ensemble Docking for Intrinsically Disordered Proteins.Journal of chemical information and modeling · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Ensemble docking for intrinsically disordered proteins.bioRxiv : the preprint server for biology · 2025
    Article
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Priya R BanerjeeDepartment of Physics, University at Buffalo, NY 14260, USA. Electronic address: prbanerj@buffalo.edu.
Alex S HolehouseDepartment of Biochemistry and Molecular Biophysics, Washington University in St. Louis, St. Louis, MO, USA.
Richard KriwackiStructural Biology Department, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Paul RobustelliDepartment of Chemistry, Dartmouth College, Hanover, NH 03755, USA.
Hao JiangDepartment of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22903, USA.
Alexander I SobolevskyDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA.
Jennifer M HurleyDepartment of Biological Sciences, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.
Joshua T MendellUT Southwestern Medical Center and Howard Hughes Medical Institute, Dallas, TX 75390, USA.

Funding

UT Southwestern NORCP30DK127984 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Jeff G McDonald · 2022 to 2026
$7.4M
Quantifying Physiologic and Pathologic Viscoelastic Phases of Biomolecular Condensates by Correlative Force and Fluorescence MicroscopyR35GM138186 · NIGMS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI BANERJEE, PRIYA R. · 2020 to 2025
$4.4M
Investigating Circadian Post-Transcriptional Regulation using Widefield Microscopy.R35GM128687 · NIGMS · RENSSELAER POLYTECHNIC INSTITUTE · PI Jennifer Marie Hurley · 2018 to 2026
$4.0M
Structure and function of Transient Receptor Potential ChannelsR01CA206573 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Alexander Sobolevsky · 2017 to 2026
$3.8M
Single-Particle Cryo-EM Characterization of AMPA Receptor Functional StatesR01NS107253 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Alexander Sobolevsky · 2018 to 2026
$3.5M
Role of Phase separation by fusion oncoproteins in oncogenesisR01CA246125 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI DENIZ, ASHOK A, KRIWACKI, RICHARD W · 2020 to 2024
$3.2M
Structural and functional principles of activation and regulation of the transient receptor potential channel TRPV3.R01AR078814 · NIAMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Alexander Sobolevsky · 2022 to 2026
$2.8M
Characterizing the binding mechanisms of castration-resistant prostate cancer therapeutics to the intrinsically disordered N-terminal domain of the androgen receptorR35GM142750 · NIGMS · DARTMOUTH COLLEGE · PI Paul Robustelli · 2021 to 2026
$2.4M
The role of long noncoding RNA CRNDE in normal physiology and cancerR01CA282036 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Joshua T Mendell · 2023 to 2026
$1.9M
Structure and Function of Ionotropic Glutamate ReceptorsR37NS083660 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Alexander Sobolevsky · 2024 to 2026
$1.7M
Developing a screening platform to identify inhibitors of pathological self-assembly of TauR03AG070510 · NIA · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI BANERJEE, PRIYA R. · 2021 to 2022
$315k
Deciphering the role of low complexity domains in dual specificity kinase functionR03TR003387 · NCATS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI BANERJEE, PRIYA R. · 2021 to 2021
$158k
NCATS NIH HHS R03 TR003387NCI NIH HHS R01 CA206573NCI NIH HHS R01 CA246125NCI NIH HHS R01 CA282036NIAMS NIH HHS R01 AR078814NIA NIH HHS R03 AG070510NIDDK NIH HHS P30 DK127984NIGMS NIH HHS R35 GM128687NIGMS NIH HHS R35 GM138186NIGMS NIH HHS R35 GM142750NINDS NIH HHS R01 NS107253NINDS NIH HHS R37 NS083660
6 · The paper itself

Abstract

Intrinsically disordered regions (IDRs) within human proteins play critical roles in cellular information processing, including signaling, transcription, stress response, DNA repair, genome organization, and RNA processing. Here, we summarize current challenges in the field and propose cutting-edge approaches to address them in physiology and disease processes, with a focus on cancer.

Indexed as

Intrinsically Disordered ProteinsBiologyBiophysicsHumansIntrinsically Disordered Proteinscancercondensatesphase separationsingle-molecule microscopy

Identifiers

PMID37949765
PMCPMC10872967

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.