Evidence map›Paper›PMID 37949678›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024

Double-Network DNA Macroporous Hydrogel Enables Aptamer-Directed Cell Recruitment to Accelerate Bone Healing.

Yali Miao, Xiao Liu, Jinshui Luo, Qian Yang, Yunhua Chen, Yingjun Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 53 citations in OpenAlex.

  1. Article
  2. Review
  3. Applications of DNA Hydrogels in Osteoporotic Bone Defects.Journal of functional biomaterials · 2026
    Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Advances in aptamer technology for target-based drug discovery.Journal of pharmaceutical analysis · 2026
    Review
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Yali MiaoSchool of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, China.
Xiao LiuSchool of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, China.
Jinshui LuoSchool of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, China.
Qian YangSchool of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, China.
Yunhua ChenSchool of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, China.ORCID 0000-0002-5543-8152
Yingjun WangSchool of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, China.ORCID 0000-0001-8218-9860
South China University of Technology · CNKey Laboratory of Guangdong Province · CNGuangdong Academy of Medical Sciences · CN

Funding

Basic and Applied Basic Research Foundation of Guangdong Province 2022A1515110882Basic and Applied Basic Research Foundation of Guangdong Province 2023A1515010977China Postdoctoral Science Foundation 2022M720856National Key Research and Development Program of China 2018YFA0703000National Natural Science Foundation of China 22072047National Natural Science Foundation of China T2288101Science and Technology Program of Guangzhou 202007020002Science and Technology Program of Guangzhou 202206040001
6 · The paper itself

Abstract

Recruiting endogenous bone marrow mesenchymal stem cells (BMSCs) in vivo to bone defect sites shows great promise in cell therapies for bone tissue engineering, which tackles the shortcomings of delivering exogenous stem cells, including limited sources, low retention, stemness loss, and immunogenicity. However, it remains challenging to efficiently recruit stem cells while simultaneously directing cell differentiation in the dynamic microenvironment and promoting neo-regenerated tissue ingrowth to achieve augmented bone regeneration. Herein, a synthetic macroporous double-network hydrogel presenting nucleic acid aptamer and nano-inducer enhances BMSCs recruitment, and osteogenic differentiation is demonstrated. An air-in-water template enables the rapid construction of highly interconnective macroporous structures, and the physical self-assembly of DNA strands and chemical cross-linking of gelatin chains synergistically generate a resilient double network. The aptamer Apt19S and black phosphorus nanosheets-specific macroporous hydrogel demonstrate highly efficient endogenous BMSCs recruitment, cell differentiation, and extracellular matrix mineralization. Notably, the enhanced calvarial bone healing with promising matrix mineralization and new bone formation is accompanied by adapting this engineered hydrogel to the bone defects. The findings suggest an appealing material approach overcoming the traditional limitations of cell-delivery therapy that can inspire the future design of next-generation hydrogel for enhanced bone tissue regeneration.

Indexed as

HydrogelsOsteogenesisBone RegenerationDNAOligonucleotidesTissue EngineeringDNAHydrogelsOligonucleotidesair-in-water emulsionbone regenerationcell recruitmentDNA hydrogelsdouble network

Identifiers

PMID37949678
PMCPMC10767401
OpenAlexW4388582576

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.