ArticleBMJ open2023
Cohort profile: the U-BIRTH study on peripartum depression and child development in Sweden.
Article in BMJ open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 7 citations in OpenAlex.
- Labour epidural analgesia and early childhood behavioural outcomes: the moderating role of maternal mental health and pro-inflammatory cytokines.Anaesthesia · 2026Article
- Patient perspectives on barriers to rTMS for peripartum depression.BMC psychiatry · 2026Article
- The Antenatal Origins of Postpartum Distress: A Retrospective Longitudinal Analysis of Depression and Anxiety Trajectories.Medical sciences (Basel, Switzerland) · 2026Article
- Association between perinatal depressive symptoms and parental cohabitation status in a Nordic high-income country.PloS one · 2026Article
- Do the early social environment and persistent peripartum depressive symptoms shape toddlers' expressive language?JCPP advances · 2025Article
- Psychometric Evaluation of the Swedish Version of the Child Behaviour Check List (CBCL) 1.5-5.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Article
- Peripartum Depression: What's New?Current psychiatry reports · 2025Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe current U-BIRTH cohort (Uppsala Birth Cohort) extends our previous cohort Biology, Affect, Stress, Imaging and Cognition (BASIC), assessing the development of children up to 11 years after birth. The U-BIRTH study aims to (1) assess the impact of exposure to peripartum mental illness on the children's development taking into account biological and environmental factors during intrauterine life and childhood; (2) identify early predictors of child neurodevelopmental and psychological problems using biophysiological, psychosocial and environmental variables available during pregnancy and early post partum.
participantsAll mothers participating in the previous BASIC cohort are invited, and mother-child dyads recruited in the U-BIRTH study are consecutively invited to questionnaire assessments and biological sampling when the child is 18 months, 6 years and 11 years old. Data collection at 18 months (n=2882) has been completed. Consent for participation has been obtained from 1946 families of children having reached age 6 and from 698 families of children having reached age 11 years. FINDINGS TO DATE: Based on the complete data from pregnancy to 18 months post partum, peripartum mental health was significantly associated with the development of attentional control and gaze-following behaviours, which are critical to cognitive and social learning later in life. Moreover, infants of depressed mothers had an elevated risk of difficult temperament and behavioural problems compared with infants of non-depressed mothers. Analyses of biological samples showed that peripartum depression and anxiety were related to DNA methylation differences in infants. However, there were no methylation differences in relation to infants' behavioural problems at 18 months of age. FUTURE PLANS: Given that the data collection at 18 months is complete, analyses are now being undertaken. Currently, assessments for children reaching 6 and 11 years are ongoing.
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