Evidence map›Paper›PMID 37949438›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2023

Transferrin Receptor-Targeted Nonspherical Microbubbles for Blood-Brain Barrier Sonopermeation.

Anshuman Dasgupta, Tao Sun, Elena Rama, Alessandro Motta, Yongzhi Zhang, Chanikarn Power, Diana Moeckel, Stecia-Marie Fletcher, Mirjavad Moosavifar, Roman Barmin and 8 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 34 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 2 countries.

Anshuman DasguptaInstitute for Experimental Molecular Imaging, RWTH Aachen University Clinic, 52074, Aachen, Germany.
Tao SunJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Boston, MA, 02134, USA.
Elena RamaInstitute for Experimental Molecular Imaging, RWTH Aachen University Clinic, 52074, Aachen, Germany.
Alessandro MottaInstitute for Experimental Molecular Imaging, RWTH Aachen University Clinic, 52074, Aachen, Germany.
Yongzhi ZhangDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Chanikarn PowerDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Diana MoeckelInstitute for Experimental Molecular Imaging, RWTH Aachen University Clinic, 52074, Aachen, Germany.
Stecia-Marie FletcherDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Mirjavad MoosavifarInstitute for Experimental Molecular Imaging, RWTH Aachen University Clinic, 52074, Aachen, Germany.
Roman BarminInstitute for Experimental Molecular Imaging, RWTH Aachen University Clinic, 52074, Aachen, Germany.
Céline PorteInstitute for Experimental Molecular Imaging, RWTH Aachen University Clinic, 52074, Aachen, Germany.
Eva Miriam BuhlElectron Microscopy Facility, Institute of Pathology, RWTH Aachen University, 52074, Aachen, Germany.
Céline BastardDWI - Leibniz Institute for Interactive Materials, RWTH Aachen University Hospital, 52074, Aachen, Germany.
Roger M PallaresInstitute for Experimental Molecular Imaging, RWTH Aachen University Clinic, 52074, Aachen, Germany.
Fabian KiesslingInstitute for Experimental Molecular Imaging, RWTH Aachen University Clinic, 52074, Aachen, Germany.
Nathan McDannoldDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Samir MitragotriJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Boston, MA, 02134, USA.
Twan LammersInstitute for Experimental Molecular Imaging, RWTH Aachen University Clinic, 52074, Aachen, Germany.ORCID https://orcid.org/0000-0002-1090-6805
RWTH Aachen University · DEBrigham and Women's Hospital · USHarvard University · USDWI – Leibniz Institute for Interactive Materials · DE

Funding

Optimization of ultrasound-mediated drug delivery to the brain under clinically relevant conditionsR01EB033307 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI MCDANNOLD, NATHAN J. · 2022 to 2025
$2.0M
European Research Council ERC-CoG 864121NIBIB NIH HHS R01 EB033307NIH HHS R01 EB033307
6 · The paper itself

Abstract

Microbubbles (MB) are widely used for ultrasound (US) imaging and drug delivery. MB are typically spherically shaped, due to surface tension. When heated above their glass transition temperature, polymer-based MB can be mechanically stretched to obtain an anisotropic shape, endowing them with unique features for US-mediated blood-brain barrier (BBB) permeation. It is here shown that nonspherical MB can be surface-modified with BBB-specific targeting ligands, thereby promoting binding to and sonopermeation of blood vessels in the brain. Actively targeted rod-shaped MB are generated via 1D stretching of spherical poly(butyl cyanoacrylate) MB and via subsequently functionalizing their shell with antitransferrin receptor (TfR) antibodies. Using US and optical imaging, it is demonstrated that nonspherical anti-TfR-MB bind more efficiently to BBB endothelium than spherical anti-TfR-MB, both in vitro and in vivo. BBB-associated anisotropic MB produce stronger cavitation signals and markedly enhance BBB permeation and delivery of a model drug as compared to spherical BBB-targeted MB. These findings exemplify the potential of antibody-modified nonspherical MB for targeted and triggered drug delivery to the brain.

Indexed as

Blood-Brain BarrierMicrobubblesReceptors, TransferrinSonicationAnimalsAntibodiesCell LineDrug Delivery SystemsEndothelial CellsFemaleLigandsMiceMice, Inbred BALB CAntibodiesLigandsReceptors, Transferrinanisotropyblood-brain barrierdrug deliverymicrobubblesPBCAultrasoundvascular targeting

Identifiers

PMID37949438
PMCPMC11238272
OpenAlexW4388583094

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.