ArticleCerebral cortex (New York, N.Y. : 1991)2024
Characterizing microstructural development in the fetal brain using diffusion MRI from 23 to 36 weeks of gestation.
Article in Cerebral cortex (New York, N.Y. : 1991), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Typical development of the human fetal subplate: Regional heterogeneity, growth, and asymmetry assessed by in vivo T2-weighted MRI.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Fully automated deep learning model for the evaluation of cavum septum pellucidum development in normal fetuses using magnetic resonance imaging: a Chinese cohort study.Quantitative imaging in medicine and surgery · 2025Article
- HERON: High-Efficiency Real-Time Motion Quantification and Re-Acquisition for Fetal Diffusion MRI.IEEE transactions on medical imaging · 2025Article
- Typical development of the human fetal subplate: regional heterogeneity, growth, and asymmetry assessed by in vivo T2-weighted MRI.bioRxiv : the preprint server for biology · 2025Article
- Improving Image Quality and Decreasing SAR With High Dielectric Constant Pads in 3 T Fetal MRI.Journal of magnetic resonance imaging : JMRI · 2025Article
- Regional Changes in the Fetal Telencephalic Wall Diffusion Metrics Across Late Second and Third Trimesters.Human brain mapping · 2025Article
- HAITCH: A framework for distortion and motion correction in fetal multi-shell diffusion-weighted MRI.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Advances in Fetal Brain Imaging.Magnetic resonance imaging clinics of North America · 2024Review
- Dynamic changes in subplate and cortical plate microstructure at the onset of cortical folding in vivo.bioRxiv : the preprint server for biology · 2024Article
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9 authors.
Funding
Abstract
We utilized motion-corrected diffusion tensor imaging (DTI) to evaluate microstructural changes in healthy fetal brains during the late second and third trimesters. Data were derived from fetal magnetic resonance imaging scans conducted as part of a prospective study spanning from 2013 March to 2019 May. The study included 44 fetuses between the gestational ages (GAs) of 23 and 36 weeks. We reconstructed fetal brain DTI using a motion-tracked slice-to-volume registration framework. Images were segmented into 14 regions of interest (ROIs) through label propagation using a fetal DTI atlas, with expert refinement. Statistical analysis involved assessing changes in fractional anisotropy (FA) and mean diffusivity (MD) throughout gestation using mixed-effects models, and identifying points of change in trajectory for ROIs with nonlinear trends. Results showed significant GA-related changes in FA and MD in all ROIs except in the thalamus' FA and corpus callosum's MD. Hemispheric asymmetries were found in the FA of the periventricular white matter (pvWM), intermediate zone, and subplate and in the MD of the ganglionic eminence and pvWM. This study provides valuable insight into the normal patterns of development of MD and FA in the fetal brain. These changes are closely linked with cytoarchitectonic changes and display indications of early functional specialization.
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