Evidence map›Paper›PMID 37948583›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

The adaptive antioxidant response during fasting-induced muscle atrophy is oppositely regulated by ZEB1 and ZEB2.

Chiara Ninfali, Marlies Cortés, M C Martínez-Campanario, Verónica Domínguez, Lu Han, Ester Tobías, Anna Esteve-Codina, Carlos Enrich, Belén Pintado, Gloria Garrabou and 1 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Chiara NinfaliGroup of Gene Regulation in Stem Cells, Cell Plasticity, Differentiation, and Cancer, Institute of Biomedical Research August Pi Sunyer (IDIBAPS), Barcelona 08036, Spain.ORCID 0000-0002-5745-6119
Marlies CortésGroup of Gene Regulation in Stem Cells, Cell Plasticity, Differentiation, and Cancer, Institute of Biomedical Research August Pi Sunyer (IDIBAPS), Barcelona 08036, Spain.ORCID 0000-0002-9313-1194
M C Martínez-CampanarioGroup of Gene Regulation in Stem Cells, Cell Plasticity, Differentiation, and Cancer, Institute of Biomedical Research August Pi Sunyer (IDIBAPS), Barcelona 08036, Spain.ORCID 0000-0002-2745-6505
Verónica DomínguezNational Center of Biotechnology (CSIC-CNB) and Center for Molecular Biology Severo Ochoa (CSIC-CBMSO), Transgenesis Facility, High Research Council (CSIC) and Autonomous University of Madrid, Cantoblanco, Madrid 28049, Spain.ORCID 0000-0003-0558-1281
Lu HanGroup of Gene Regulation in Stem Cells, Cell Plasticity, Differentiation, and Cancer, Institute of Biomedical Research August Pi Sunyer (IDIBAPS), Barcelona 08036, Spain.ORCID 0000-0002-7527-4829
Ester TobíasGroup of Muscle Research and Mitochondrial Function, Institute of Biomedical Research August Pi Sunyer (IDIBAPS), University of Barcelona School of Medicine, Hospital Clínic of Barcelona, and Rare Diseases Networking Biomedical Research Center (CIBERer), Barcelona 08036, Spain.
Anna Esteve-CodinaNational Center for Genomics Analysis (CNAG), Barcelona 08028, Spain.ORCID 0000-0003-0361-2873
Carlos EnrichDepartment of Biomedicine, University of Barcelona School of Medicine, and Institute of Biomedical Research August Pi Sunyer (IDIBAPS), Barcelona 08036, Spain.
Belén PintadoNational Center of Biotechnology (CSIC-CNB) and Center for Molecular Biology Severo Ochoa (CSIC-CBMSO), Transgenesis Facility, High Research Council (CSIC) and Autonomous University of Madrid, Cantoblanco, Madrid 28049, Spain.
Gloria GarrabouGroup of Muscle Research and Mitochondrial Function, Institute of Biomedical Research August Pi Sunyer (IDIBAPS), University of Barcelona School of Medicine, Hospital Clínic of Barcelona, and Rare Diseases Networking Biomedical Research Center (CIBERer), Barcelona 08036, Spain.
Antonio PostigoGroup of Gene Regulation in Stem Cells, Cell Plasticity, Differentiation, and Cancer, Institute of Biomedical Research August Pi Sunyer (IDIBAPS), Barcelona 08036, Spain.ORCID 0000-0003-4605-2634
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer · ESCentro de Biología Molecular Severo Ochoa · ESCentro Nacional de Análisis Genómico · ESInstitució Catalana de Recerca i Estudis Avançats · ES

Funding

Duchenne Parent Project DPPE/01_2018Government of Catalonia | Agència de Gestió d'Ajuts Universitaris i de Recerca (AGAUR) 2017-SGR-1174 and 2021-SGR 01328MEC | Agencia Estatal de Investigación (AEI) SAF2017-84918-R and PID2020-116338RB-I00
6 · The paper itself

Abstract

Reactive oxygen species (ROS) serve important homeostatic functions but must be constantly neutralized by an adaptive antioxidant response to prevent supraphysiological levels of ROS from causing oxidative damage to cellular components. Here, we report that the cellular plasticity transcription factors ZEB1 and ZEB2 modulate in opposing directions the adaptive antioxidant response to fasting in skeletal muscle. Using transgenic mice in which

Indexed as

AntioxidantsZinc Finger E-box-Binding Homeobox 1AnimalsFastingMiceMice, TransgenicMuscular AtrophyReactive Oxygen SpeciesZinc Finger E-box Binding Homeobox 2AntioxidantsReactive Oxygen SpeciesZEB1 protein, mouseZEB2 protein, mouseZinc Finger E-box-Binding Homeobox 1Zinc Finger E-box Binding Homeobox 2antioxidant responsemuscle atrophyNRF2reactive oxygen speciesZEB1 and ZEB2

Identifiers

PMID37948583
PMCPMC10655555
OpenAlexW4388562814

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.