Evidence map›Paper›PMID 37948561›Full record

ArticleArchives of endocrinology and metabolism2023

Genetic polymorphisms in the angiotensin converting enzyme, actinin 3 and paraoxonase 1 genes in women with diabetes and hypertension.

Gabrielle Gaspar Arejano, Laura Vargas Hoffmann, Linoska Ferreira Wyse, Poliana Espíndola Correia, Simone Pieniz, Fabiana Torma Botelho, Augusto Schneider, Ines Schadock, Carlos Castilho Barros

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of endocrinology and metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Gabrielle Gaspar ArejanoLaboratório de Nutrigenômica, Universidade Federal de Pelotas, Pelotas, RS, Brasil.
Laura Vargas HoffmannLaboratório de Nutrigenômica, Universidade Federal de Pelotas, Pelotas, RS, Brasil.
Linoska Ferreira WyseLaboratório de Nutrigenômica, Universidade Federal de Pelotas, Pelotas, RS, Brasil.
Poliana Espíndola CorreiaUniversidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil.
Simone PienizLaboratório de Nutrigenômica, Universidade Federal de Pelotas, Pelotas, RS, Brasil.
Fabiana Torma BotelhoLaboratório de Nutrigenômica, Universidade Federal de Pelotas, Pelotas, RS, Brasil.
Augusto SchneiderLaboratório de Nutrigenômica, Universidade Federal de Pelotas, Pelotas, RS, Brasil.
Ines SchadockUniversidade Federal de Rio Grande, Rio Grande, RS, Brasil.
Carlos Castilho BarrosLaboratório de Nutrigenômica, Universidade Federal de Pelotas, Pelotas, RS, Brasil, barrosccpel@gmail.com.
Universidade Federal de Pelotas · BRUniversidade Federal do Rio Grande · BRUniversidade Federal do Rio Grande do Sul · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To study associations between polymorphisms in the angiotensin converting enzyme (ACE I/D), actinin 3 (ACTN3 R577X) and paraoxonase 1 (PON1 T(-107)C) genes and chronic diseases (diabetes and hypertension) in women. Materials and methods: Genomic DNA was extracted from saliva samples of 78 women between 18 and 59 years old used for genetic polymorphism screening. Biochemical data were collected from the medical records in Basic Health Units from Southern Brazil. Questionnaires about food consumption, physical activity level and socioeconomic status were applied. Results: The XX genotype of ACTN3 was associated with low HDL levels and high triglycerides, total cholesterol and glucose levels. Additionally, high triglycerides and LDL levels were observed in carriers of the TT genotype of PON1, and lower total cholesterol levels were associated to the CC genotype. As expected, women with diabetes/hypertense had increased body weight, BMI (p = 0.02), waist circumference (p = 0.01), body fat percentage, blood pressure (p = 0.02), cholesterol, triglycerides (p = 0.02), and blood glucose (p = 0.01), when compared to the control group. Conclusion: Both ACTN3 R577X and PON1 T(-107)C polymorphisms are associated with nutritional status and blood glucose and lipid levels in women with diabetes/hypertense. These results contribute to genetic knowledge about predisposition to obesity-related diseases.

Indexed as

Diabetes MellitusHypertensionActininAdolescentAdultAryldialkylphosphataseBlood GlucoseCholesterolFemaleGenotypeHumansMiddle AgedPeptidyl-Dipeptidase APolymorphism, GeneticTriglyceridesYoung AdultACE protein, humanActininACTN3 protein, humanAryldialkylphosphataseBlood GlucoseCholesterolPeptidyl-Dipeptidase APON1 protein, humanTriglyceridesanthropometric parametersmetabolic parametersNoncommunicable diseasesnutritional statuspolymorphism

Identifiers

PMID37948561
PMCPMC10916801
OpenAlexW4388603531

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.