Evidence map›Paper›PMID 37948524›Full record

ArticleScience advances2023

CLIP-Seq analysis enables the design of protective ribosomal RNA bait oligonucleotides against

Juan A Ortega, Ivan R Sasselli, Marco Boccitto, Andrew C Fleming, Tyler R Fortuna, Yichen Li, Kohei Sato, Tristan D Clemons, Elizabeth D Mckenna, Thao P Nguyen and 7 more

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Decoding Nucleotide Repeat Expansion Diseases: Novel Insights fromInternational journal of molecular sciences · 2024
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 2 countries.

Juan A OrtegaThe Ken & Ruth Davee Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0001-6242-7761
Ivan R SasselliDepartment of Chemistry, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0001-6062-2440
Marco BoccittoRNA Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.ORCID 0000-0002-5722-9186
Andrew C FlemingThe Ken & Ruth Davee Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0002-5889-871X
Tyler R FortunaDepartment of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA.ORCID 0000-0003-0744-9532
Yichen LiDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Kohei SatoDepartment of Chemistry, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0002-8948-8537
Tristan D ClemonsDepartment of Chemistry, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0001-8042-0141
Elizabeth D MckennaThe Ken & Ruth Davee Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0003-2342-452X
Thao P NguyenThe Ken & Ruth Davee Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0001-9802-3144
Eric N AndersonDepartment of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA.ORCID 0000-0003-2533-8764
Jesus AsinDepartment of Statistical Methods, School of Engineering, University of Zaragoza, Zaragoza 50018, Spain.ORCID 0000-0002-0174-789X
Justin K IchidaDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Udai B PandeyDepartment of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA.ORCID 0000-0002-6267-0179
Sandra L WolinRNA Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.ORCID 0000-0001-6730-0399
Samuel I StuppDepartment of Chemistry, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0002-5491-7442
Evangelos KiskinisThe Ken & Ruth Davee Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0001-8342-8616
Northwestern University · USUniversity of Pittsburgh · USNational Cancer Institute · USUniversity of Southern California · USUniversidad de Zaragoza · ES

Funding

Validating Secretory Autophagy as a Therapeutic Strategy for Diverse Forms of ALS and FTDR01NS097850 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ICHIDA, JUSTIN KAWIKA · 2016 to 2024
$5.5M
Leveraging Natural Phenotypic Variations of Heterogenous ALS Populations-in-a-Dish to Enable Scalable Drug DiscoveryR01NS131409 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GOODARZI, HANI, ICHIDA, JUSTIN KAWIKA · 2022 to 2025
$4.9M
Determining How Defective Nucleo-Cytoplasmic Trafficking Leads To Neurodegeneration In C9orf72-Related ALS And FTDR01NS104219 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KISKINIS, EVANGELOS · 2018 to 2022
$2.3M
Defining The Impaired Proteostasis Network in ALS Patient Motor NeuronsR21NS107761 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KISKINIS, EVANGELOS, SAVAS, JEFFREY NICHOLAS · 2018 to 2019
$435k
NINDS NIH HHS R01 NS097850NINDS NIH HHS R01 NS104219NINDS NIH HHS R01 NS131409NINDS NIH HHS R21 NS107761
6 · The paper itself

Abstract

Amyotrophic lateral sclerosis and frontotemporal dementia patients with a hexanucleotide repeat expansion in

Indexed as

Amyotrophic Lateral SclerosisFrontotemporal DementiaAnimalsC9orf72 ProteinChromatin Immunoprecipitation SequencingDNA Repeat ExpansionDrosophilaHumansRNARNA, RibosomalC9orf72 ProteinRNARNA, Ribosomal

Identifiers

PMID37948524
PMCPMC10637751
OpenAlexW4388561605

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.