Evidence map›Paper›PMID 37948519›Full record

ArticleScience advances2023

Ryang Hwa Lee, Siddaraju V Boregowda, Taeko Shigemoto-Kuroda, EunHye Bae, Christopher L Haga, Colette A Abbery, Kayla J Bayless, Andrew Haskell, Carl A Gregory, Luis A Ortiz and 1 more

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Ryang Hwa LeeDepartment of Cell Biology and Genetics, School of Medicine, Texas A&M University, College Station, TX, 77845, USA.ORCID 0000-0001-7112-3583
Siddaraju V BoregowdaDepartment of Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technology, Jupiter, FL, 33458, USA.ORCID 0000-0001-8695-4056
Taeko Shigemoto-KurodaDepartment of Cell Biology and Genetics, School of Medicine, Texas A&M University, College Station, TX, 77845, USA.
EunHye BaeDepartment of Cell Biology and Genetics, School of Medicine, Texas A&M University, College Station, TX, 77845, USA.ORCID 0000-0003-4589-7889
Christopher L HagaDepartment of Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technology, Jupiter, FL, 33458, USA.
Colette A AbberyDepartment of Cell Biology and Genetics, School of Medicine, Texas A&M University, College Station, TX, 77845, USA.ORCID 0000-0003-2637-1128
Kayla J BaylessDepartment of Cell Biology and Genetics, School of Medicine, Texas A&M University, College Station, TX, 77845, USA.ORCID 0000-0001-7862-3978
Andrew HaskellDepartment of Cell Biology and Genetics, School of Medicine, Texas A&M University, College Station, TX, 77845, USA.ORCID 0000-0003-1170-2254
Carl A GregoryDepartment of Cell Biology and Genetics, School of Medicine, Texas A&M University, College Station, TX, 77845, USA.
Luis A OrtizDepartment of Environmental Health, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0000-0003-4510-7066
Donald G PhinneyDepartment of Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technology, Jupiter, FL, 33458, USA.ORCID 0000-0002-8688-2619
Texas A&M University · USScripps Research Institute · USUniversity of Pittsburgh · US

Funding

A Clinical Indications Prediction (CLIP) Scale for Human Mesenchymal Stem CellsR01HL144089 · NHLBI · UNIVERSITY OF FLORIDA · PI Donald G Phinney · 2018 to 2026
$5.4M
Extracellular Vesicles Produced by Mesenchymal Stem Cells as Novel Therapy for Autoimmune UveitisR01EY029350 · NEI · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI LEE, RYANG HWA · 2019 to 2023
$1.8M
NEI NIH HHS R01 EY029350NHLBI NIH HHS R01 HL144089
6 · The paper itself

Abstract

Mesenchymal stem/stromal cells (MSCs) have been evaluated in >1500 clinical trials, but outcomes remain suboptimal because of knowledge gaps in quality attributes that confer potency. We show that TWIST1 directly represses

Indexed as

Mesenchymal Stem CellsAnti-Inflammatory AgentsBiomarkersBone Marrow CellsCell Adhesion MoleculesCell DifferentiationHumansImmunologic FactorsNuclear ProteinsTwist-Related Protein 1Anti-Inflammatory AgentsBiomarkersCell Adhesion MoleculesImmunologic FactorsNuclear ProteinsTNFAIP6 protein, humanTWIST1 protein, humanTwist-Related Protein 1

Identifiers

PMID37948519
PMCPMC10637745
OpenAlexW4388562556

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.