ArticleScience advances2023
Optimal control pulses for the 1.2-GHz (28.2-T) NMR spectrometers.
Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- Optimal control of spin systems.Science advances · 2026Review
- Anisotropic NMR as a Crucial Tool for Differentiation of Epimers With High Conformational Flexibility.Angewandte Chemie (International ed. in English) · 2026Article
- Nuclear-Spin Hyperpolarization of Biomolecules by Optically Enhanced NMR at Ultra-High Field.Journal of the Chinese Chemical Society. Zhongguo hua xue hui (Taipei, Taiwan) · 2026Article
- LowCOST-HSQC Variants for Fast-Pulsing High ωMagnetic resonance in chemistry : MRC · 2026Article
- Single spin exact gradients for the optimization of complex pulses and pulse sequences.Journal of biomolecular NMR · 2026Article
- Ultrabroadband 1D and 2D NMR Spectroscopy.Angewandte Chemie (International ed. in English) · 2026Article
- Nuclear Magnetic Resonance Based Metabolomics-A Rising Star in Traditional Chinese Medicine Research.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Seedless: on-the-fly pulse calculation for NMR experiments.Nature communications · 2025Article
- OptimizedInternational journal of molecular sciences · 2025Article
- Pseudo rotary resonance relaxation dispersion effects in isotropic samples.Magnetic resonance (Gottingen, Germany) · 2025Article
- Deep learning enabled ultra-high quality NMR chemical shift resolved spectra.Chemical science · 2024Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ability to measure nuclear magnetic resonance (NMR) spectra with a large sample volume is crucial for concentration-limited biological samples to attain adequate signal-to-noise (S/N) ratio. The possibility to measure with a 5-mm cryoprobe is currently absent at the 1.2-GHz NMR instruments due to the exceedingly high radio frequency power demands, which is four times compared to 600-MHz instruments. Here, we overcome the high-power demands by designing optimal control (OC) pulses with up to 20 times lower power requirements than currently necessary at a 1.2-GHz spectrometer. We show that multidimensional biomolecular NMR experiments constructed using these OC pulses can bestow improvement in the S/N ratio of up to 26%. With the expected power limitations of a 5-mm cryoprobe, we observe an enhancement in the S/N ratio of more than 240% using our OC sequences. This motivates the development of a cryoprobe with a larger volume than the current 3-mm cryoprobes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.