Evidence map›Paper›PMID 37948328›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024

Nongenetic Optical Modulation of Pluripotent Stem Cells Derived Cardiomyocytes Function in the Red Spectral Range.

Carlotta Ronchi, Camilla Galli, Gabriele Tullii, Camilla Marzuoli, Marta Mazzola, Marco Malferrari, Silvia Crasto, Stefania Rapino, Elisa Di Pasquale, Maria Rosa Antognazza

Open access · goldAbstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Complementary biomolecular coassemblies direct energy transport for cardiac photostimulators.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Phage-Templated Synthesis of Targeted Photoactive 1D-Thiophene Nanoparticles.Small (Weinheim an der Bergstrasse, Germany) · 2025
    Article
  7. Tapered fiber probe-based optical cardiac pacemaker.Frontiers in bioengineering and biotechnology · 2025
    Article
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Carlotta RonchiCenter for Nano Science and Technology, Istituto Italiano di Tecnologia, Milano, 20133, Italy.
Camilla GalliHumanitas Cardio Center, IRCCS Humanitas Research Hospital, Via Manzoni 56, Rozzano, Milan, 20089, Italy.
Gabriele TulliiCenter for Nano Science and Technology, Istituto Italiano di Tecnologia, Milano, 20133, Italy.
Camilla MarzuoliCenter for Nano Science and Technology, Istituto Italiano di Tecnologia, Milano, 20133, Italy.
Marta MazzolaHumanitas Cardio Center, IRCCS Humanitas Research Hospital, Via Manzoni 56, Rozzano, Milan, 20089, Italy.
Marco MalferrariDepartment of Chemistry, University of Bologna, ''Giacomo Ciamician,'', via Francesco Selmi 2, Bologna, 40126, Italy.
Silvia CrastoHumanitas Cardio Center, IRCCS Humanitas Research Hospital, Via Manzoni 56, Rozzano, Milan, 20089, Italy.
Stefania RapinoDepartment of Chemistry, University of Bologna, ''Giacomo Ciamician,'', via Francesco Selmi 2, Bologna, 40126, Italy.
Elisa Di PasqualeHumanitas Cardio Center, IRCCS Humanitas Research Hospital, Via Manzoni 56, Rozzano, Milan, 20089, Italy.
Maria Rosa AntognazzaCenter for Nano Science and Technology, Istituto Italiano di Tecnologia, Milano, 20133, Italy.ORCID 0000-0003-4599-2384
Italian Institute of Technology · ITIRCCS Humanitas Research Hospital · ITUniversity of Bologna · ITInstitute of Genetic and Biomedical Research · IT

Funding

Horizon 2020 Framework Programme 828984
6 · The paper itself

Abstract

Optical stimulation in the red/near infrared range recently gained increasing interest, as a not-invasive tool to control cardiac cell activity and repair in disease conditions. Translation of this approach to therapy is hampered by scarce efficacy and selectivity. The use of smart biocompatible materials, capable to act as local, NIR-sensitive interfaces with cardiac cells, may represent a valuable solution, capable to overcome these limitations. In this work, a far red-responsive conjugated polymer, namely poly[2,1,3-benzothiadiazole-4,7-diyl[4,4-bis(2-ethylhexyl)-4H-cyclopenta[2,1-b:3,4-b']dithiophene-2,6-diyl]] (PCPDTBT) is proposed for the realization of photoactive interfaces with cardiomyocytes derived from pluripotent stem cells (hPSC-CMs). Optical excitation of the polymer turns into effective ionic and electrical modulation of hPSC-CMs, in particular by fastening Ca

Indexed as

Myocytes, CardiacPluripotent Stem CellsPolymersPolymersCa2+ signalingconjugated polymerselectrical activityhuman pluripotent stem cell derived cardiomyocytesoptical stimulationreactive oxygen species

Identifiers

PMID37948328
PMCPMC10797444
OpenAlexW4388564433

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.