Evidence map›Paper›PMID 37947916›Full record

ArticleBiochemical genetics2024

TLR4 Polymorphisms (T399I/D299G) Association with Schizophrenia and Bipolar Disorder in a Tunisian Population.

Youssef Aflouk, Hana Saoud, Oumaima Inoubli, Saloua Yacoub, Ferid Zaafrane, Lotfi Gaha, Besma Bel Hadj Jrad

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Article in Biochemical genetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Youssef AfloukLaboratory of Genetics, Biodiversity and Valorization of Bioresources GBVB (LR11ES41), Higher Institute of Biotechnology of Monastir (ISBM), University of Monastir, Avenue Taher Haded, 5000, Monastir, Tunisia. afloukyoussef1@gmail.com.ORCID https://orcid.org/0000-0002-1155-4039
Hana SaoudLaboratory of Genetics, Biodiversity and Valorization of Bioresources GBVB (LR11ES41), Higher Institute of Biotechnology of Monastir (ISBM), University of Monastir, Avenue Taher Haded, 5000, Monastir, Tunisia.
Oumaima InoubliLaboratory of Genetics, Biodiversity and Valorization of Bioresources GBVB (LR11ES41), Higher Institute of Biotechnology of Monastir (ISBM), University of Monastir, Avenue Taher Haded, 5000, Monastir, Tunisia.
Saloua YacoubRegional Center of Blood Transfusion, University Hospital Farhat Hached, 4000, Sousse, Tunisia.
Ferid ZaafraneDepartment of Psychiatry and Vulnerability to Psychoses Laboratory-CHU Fattouma Bourguiba Monastir, University of Monastir, 5000, Monastir, Tunisia.
Lotfi GahaDepartment of Psychiatry and Vulnerability to Psychoses Laboratory-CHU Fattouma Bourguiba Monastir, University of Monastir, 5000, Monastir, Tunisia.
Besma Bel Hadj JradLaboratory of Genetics, Biodiversity and Valorization of Bioresources GBVB (LR11ES41), Higher Institute of Biotechnology of Monastir (ISBM), University of Monastir, Avenue Taher Haded, 5000, Monastir, Tunisia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immune dysregulation has been widely described in the pathophysiology of schizophrenia (SCZ) and bipolar disorder (BD). Particularly, TLR4-altered activation was proposed as one of the underlying processes of psychosis onset. Since TLR4 activation was altered by T399I and D299G polymorphisms, we hypothesized that those variants could present common genetic factors of SCZ and BD. A total of 293 healthy volunteers and 335 psychotic patients were genotyped using PCR-RFLP. Genotype, allele, and haplotype distribution between controls and patients were evaluated according to clinical parameters. Statistical analyses were adjusted by logistic regression. In dominant model, T399I CT + TT and allele frequency were significantly higher in controls compared to psychotic population (p = 0.004, p = 0.002, respectively), SCZ (p = 0.02, p = 0.01, respectively), and BD (p = 0.03, p = 0.02, respectively). Similarly, D299G AG + GG and allele frequency were significantly higher in controls compared to psychotic population (p = 0.04, p = 0.04, respectively) and SCZ (p = 0.04, p = 0.03, respectively). T399I CT + TT and T allele were overrepresented in controls compared to paranoid subgroup (P

Indexed as

Bipolar DisorderSchizophreniaToll-Like Receptor 4AdultCase-Control StudiesFemaleGene FrequencyGenetic Predisposition to DiseaseGenotypeHaplotypesHumansMaleMiddle AgedPolymorphism, Single NucleotideTunisiaTLR4 protein, humanToll-Like Receptor 4Bipolar disorderD299GSchizophreniaT399ITLR4

Identifiers

PMID37947916

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.