ArticleLasers in medical science2023
Efficacy of skin rejuvenation with a fractional 1927-nm thulium laser alone or combined with a chemical peel: a controlled histopathological preliminary study in a mouse model.
Article in Lasers in medical science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- Thulium laser (1927 nm) for dermatological conditions: a systematic review.Lasers in medical science · 2025Pooled it
- Radiofrequency Microneedling With 1927 nm Thulium Laser Versus Radiofrequency Microneedling Monotherapy for Rejuvenation of Photoaged Skin.Journal of cosmetic dermatology · 2026Trial
- Efficacy of combined 1927 nm thulium fiber laser and supramolecular salicylic acid in photoaging treatment.Lasers in medical science · 2025Trial
- Supramolecular Salicylic Acid Alleviates Skin Photoaging by Increasing Collagen Density and Elasticity.Aesthetic plastic surgery · 2025Trial
- Photothermolysis with 1550 nm Fractional Laser Promotes Regeneration of Gingival Mucosa.Bioengineering (Basel, Switzerland) · 2025Article
- Energy-Based Skin Rejuvenation: A Review of Mechanisms and Thermal Effects.Journal of cosmetic dermatology · 2025Review
- Combining Fractional 1927 nm Thulium Laser and Subdermal 1470 nm Diode Laser for Facial Aesthetic Procedures: Two Case Reports.Journal of lasers in medical sciences · 2025Article
- A Novel Treatment of Acne Vulgaris Using a 1927 nm Fractional Thulium Laser: A Case Series.Clinical, cosmetic and investigational dermatology · 2024Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many patients demand minimally invasive treatments for skin rejuvenation, such as nonablative laser and superficial chemical peels. Combination therapy yet has not been studied histopathologically. The purpose of this study is to assess the histopathological efficacy of a 1927-nm thulium laser-assisted salicylic acid (SA) peel in skin rejuvenation. A six-segment table was drawn on the shaved back of C57BL/6 mouse. All segments were irradiated with the thulium laser-different tips and passes were used for specific segments. A 30% SA peel was then applied to the right-hand segments. After treatment, the skin samples were collected from each segment and examined for dermal thickness, collagen density, and melanin content. Greater thickness was seen in the combination therapy group compared with the laser alone group and in those segments receiving more passes with larger beam-sized tip. Collagen density increased in all treated skin segments, irrespective of the group. No adverse events were noted in the treated areas. The sample size was small and mouse skin has histological differences with human skin. The combination of a thulium laser and 30% SA peel has a synergistic effect on dermal thickness, so that can be suggested as a novel skin rejuvenation technique.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.