Evidence map›Paper›PMID 37947776›Full record

ArticleJournal of agricultural and food chemistry2023

Novel Approaches for Elongation of Fish Oils into Very-Long-Chain Polyunsaturated Fatty Acids and Their Enzymatic Interesterification into Glycerolipids.

Tereza Honzíková, Martin-Paul Agbaga, Robert Eugene Anderson, Richard Brush, Mohiuddin Ahmad, Lenka Musílková, Karolína Šejstalová, Katsiaryna Alishevich, Radek Beneš, Petra Šimicová and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of agricultural and food chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Biomedicines · 2024
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Tereza HonzíkováDepartment of Dairy, Fat and Cosmetics, Faculty of Food and Biochemical Technology, University of Chemistry and Technology, Technická 3, 166 28 Prague, Czechia.
Martin-Paul Agbaga
Robert Eugene Anderson
Richard Brush
Mohiuddin Ahmad
Lenka MusílkováThe Department of Chemistry of Natural Compounds, Faculty of Food and Biochemical Technology, University of Chemistry and Technology, Technická 5, 166 28 Prague, Czechia.
Karolína ŠejstalováThe Department of Chemistry of Natural Compounds, Faculty of Food and Biochemical Technology, University of Chemistry and Technology, Technická 5, 166 28 Prague, Czechia.
Katsiaryna AlishevichDepartment of Dairy, Fat and Cosmetics, Faculty of Food and Biochemical Technology, University of Chemistry and Technology, Technická 3, 166 28 Prague, Czechia.
Radek BenešDepartment of Dairy, Fat and Cosmetics, Faculty of Food and Biochemical Technology, University of Chemistry and Technology, Technická 3, 166 28 Prague, Czechia.ORCID 0000-0001-6562-5480
Petra ŠimicováDepartment of Dairy, Fat and Cosmetics, Faculty of Food and Biochemical Technology, University of Chemistry and Technology, Technická 3, 166 28 Prague, Czechia.
Markéta BerčíkováDepartment of Dairy, Fat and Cosmetics, Faculty of Food and Biochemical Technology, University of Chemistry and Technology, Technická 3, 166 28 Prague, Czechia.
Vladimír FilipDepartment of Dairy, Fat and Cosmetics, Faculty of Food and Biochemical Technology, University of Chemistry and Technology, Technická 3, 166 28 Prague, Czechia.
Jan KyselkaDepartment of Dairy, Fat and Cosmetics, Faculty of Food and Biochemical Technology, University of Chemistry and Technology, Technická 3, 166 28 Prague, Czechia.ORCID 0000-0003-4071-0480
University of Chemistry and Technology, Prague · CZDean McGee Eye Institute · USUniversity of Oklahoma Health Sciences Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Elongation of the Very-Long-Chain Fatty Acids-4 (ELOVL4) enzyme that is expressed in neuronal tissues, sperm, and testes mediates biosynthesis of very-long-chain polyunsaturated fatty acids (VLC-PUFAs) from dietary long chain PUFAs (LC-PUFAs). The VLC-PUFAs are critical for neuronal and reproductive function. Therefore, mutations in ELOVL4 that affect VLC-PUFA biosynthesis contribute to retinal degenerative diseases including Autosomal Dominant Stargardt-like Macular Dystrophy (STGD3). Recent studies have also shown not only a depletion of retinal VLC-PUFAs with normal aging but also a more significant loss of VLC-PUFAs in donor eyes of patients with age-related macular degeneration (AMD). However, currently, there are no natural sources of VLC-PUFAs to be evaluated as dietary supplements for the attenuation of retinal degeneration in animal models of STGD3. Here, we report the development of a novel chemical approach for elongation of eicosapentaenoic (C20:5

Indexed as

Fish OilsMembrane ProteinsAnimalsFatty AcidsFatty Acids, UnsaturatedHumansMacular DegenerationMaleRetinaSemenFatty AcidsFatty Acids, UnsaturatedFish OilsMembrane Proteinsdocosahexaenoic acideicosapentaenoic acidELOVL4enzymatic interesterificationfish oil concentrategreen chemistrylipasesvery-long-chain polyunsaturated fatty acids

Identifiers

PMID37947776
PMCPMC10682991
OpenAlexW4388565377

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.