Evidence map›Paper›PMID 37947653›Full record

ArticleCells2023

GRF2 Is Crucial for Cone Photoreceptor Viability and Ribbon Synapse Formation in the Mouse Retina.

David Jimeno, Concepción Lillo, Pedro de la Villa, Nuria Calzada, Eugenio Santos, Alberto Fernández-Medarde

Open access · goldAbstract read
In one paragraph

Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 69% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

David JimenoCentro de Investigación del Cáncer-Instituto de Biologıá Molecular y Celular del Cáncer (CSIC-Universidad de Salamanca) and CIBERONC, 37007 Salamanca, Spain.
Concepción LilloINCYL, IBSAL (Universidad de Salamanca), 37006 Salamanca, Spain.ORCID 0000-0001-5814-9826
Pedro de la VillaDepartamento de Biología de Sistemas, Universidad de Alcalá, 28871 Alcalá de Henares, and IRYCIS, 28034 Madrid, Spain.ORCID 0000-0001-9856-6616
Nuria CalzadaCentro de Investigación del Cáncer-Instituto de Biologıá Molecular y Celular del Cáncer (CSIC-Universidad de Salamanca) and CIBERONC, 37007 Salamanca, Spain.ORCID 0000-0003-4536-8581
Eugenio SantosCentro de Investigación del Cáncer-Instituto de Biologıá Molecular y Celular del Cáncer (CSIC-Universidad de Salamanca) and CIBERONC, 37007 Salamanca, Spain.ORCID 0000-0003-3565-0321
Alberto Fernández-MedardeCentro de Investigación del Cáncer-Instituto de Biologıá Molecular y Celular del Cáncer (CSIC-Universidad de Salamanca) and CIBERONC, 37007 Salamanca, Spain.ORCID 0000-0002-1230-5501
Universidad de Salamanca · ESUniversidad de Alcalá · ES

Funding

Fundación Memoria Samuel Solórzano Barruso FS/14-2021Fundación Memoria Samuel Solórzano Barruso FS/22-2019Fundación Memoria Samuel Solórzano Barruso FS/32-2020Fundación Ramón Areces CIVP19A5942Instituto de Salud Carlos III FIS PI19/00934Instituto de Salud Carlos III FIS-PI22/01538Junta de Castilla y León SA264P18-UIC 076
6 · The paper itself

Abstract

Using constitutive GRF1/2 knockout mice, we showed previously that GRF2 is a key regulator of nuclear migration in retinal cone photoreceptors. To evaluate the functional relevance of that cellular process for two putative targets of the GEF activity of GRF2 (RAC1 and CDC42), here we compared the structural and functional retinal phenotypes resulting from conditional targeting of RAC1 or CDC42 in the cone photoreceptors of constitutive GRF2

Indexed as

Guanine Nucleotide-Releasing Factor 2Retinal Cone Photoreceptor CellsAnimalsMiceMice, Knockoutras Guanine Nucleotide Exchange FactorsRetinaSynapsesGuanine Nucleotide-Releasing Factor 2Rasgrf2 protein, mouseras Guanine Nucleotide Exchange FactorsCDC42cell deathcone photoreceptordegenerationGRF2nuclear movementRAC1retinaribbon synapsis

Identifiers

PMID37947653
PMCPMC10650203
OpenAlexW4388333546

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.