Evidence map›Paper›PMID 37947420›Full record

ReviewMicrobiology and molecular biology reviews : MMBR2023

From microbiome composition to functional engineering, one step at a time.

Sebastian Dan Burz, Senka Causevic, Alma Dal Co, Marija Dmitrijeva, Philipp Engel, Daniel Garrido-Sanz, Gilbert Greub, Siegfried Hapfelmeier, Wolf-Dietrich Hardt, Vassily Hatzimanikatis and 27 more

Abstract readReview
In one paragraph

Review in Microbiology and molecular biology reviews : MMBR, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

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  8. One Health, One Microbiome.Microbiome · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors.

Sebastian Dan BurzDepartment of Fundamental Microbiology, University of Lausanne, Lausanne, Switzerland.
Senka CausevicDepartment of Fundamental Microbiology, University of Lausanne, Lausanne, Switzerland.ORCID 0000-0001-7930-3968
Alma Dal CoDepartment of Computational Biology, University of Lausanne, Lausanne, Switzerland.
Marija DmitrijevaDepartment of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.
Philipp EngelDepartment of Fundamental Microbiology, University of Lausanne, Lausanne, Switzerland.ORCID 0000-0002-4678-6200
Daniel Garrido-SanzDepartment of Fundamental Microbiology, University of Lausanne, Lausanne, Switzerland.ORCID 0000-0003-3279-6421
Gilbert GreubInstitut de microbiologie, CHUV University Hospital Lausanne, Lausanne, Switzerland.ORCID 0000-0001-9529-3317
Siegfried HapfelmeierInstitute for Infectious Diseases, University of Bern, Bern, Switzerland.ORCID 0000-0002-6913-7932
Wolf-Dietrich HardtInstitute of Microbiology, ETH Zürich, Zürich, Switzerland.ORCID 0000-0002-9892-6420
Vassily HatzimanikatisLaboratory of Computational Systems Biotechnology, EPF Lausanne, Lausanne, Switzerland.
Clara Margot HeimanDepartment of Fundamental Microbiology, University of Lausanne, Lausanne, Switzerland.ORCID 0000-0003-4550-7537
Mathias Klaus-Maria HerzogInstitute of Microbiology, ETH Zürich, Zürich, Switzerland.
Alyson HockenberrySwiss Federal Institute for Aquatic Research, Dübendorf, Switzerland.
Christoph KeelDepartment of Fundamental Microbiology, University of Lausanne, Lausanne, Switzerland.ORCID 0000-0002-8968-735X
Andreas KepplerInstitute of Microbiology, ETH Zürich, Zürich, Switzerland.ORCID 0009-0003-5084-4420
Soon-Jae LeeDepartment of Ecology and Evolution, University of Lausanne, Lausanne, Switzerland.ORCID 0000-0002-7216-0236
Julien LuneauDepartment of Fundamental Microbiology, University of Lausanne, Lausanne, Switzerland.
Lukas MalfertheinerDepartment of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.ORCID 0000-0002-5697-2007
Sara MitriDepartment of Fundamental Microbiology, University of Lausanne, Lausanne, Switzerland.ORCID 0000-0003-3930-5357
Bidong NgyuenInstitute of Microbiology, ETH Zürich, Zürich, Switzerland.
Omid OftadehLaboratory of Computational Systems Biotechnology, EPF Lausanne, Lausanne, Switzerland.
Alan R PachecoInstitute of Microbiology, ETH Zürich, Zürich, Switzerland.ORCID 0000-0002-1128-3232
François PeaudecerfInstitute of Environmental Engineering, ETH Zürich, Zürich, Switzerland.ORCID 0000-0003-0295-4556
Grégory ReschCenter for Research and Innovation in Clinical Pharmaceutical Sciences, CHUV University Hospital Lausanne, Lausanne, Switzerland.ORCID 0000-0003-2341-4591
Hans-Joachim RuscheweyhInstitute of Microbiology, ETH Zürich, Zürich, Switzerland.
Asli SahinLaboratory of Computational Systems Biotechnology, EPF Lausanne, Lausanne, Switzerland.
Ian R SandersDepartment of Ecology and Evolution, University of Lausanne, Lausanne, Switzerland.
Emma SlackDepartment of Health Sciences and Technology, ETH Zürich, Zürich, Switzerland.
Shinichi SunagawaInstitute of Microbiology, ETH Zürich, Zürich, Switzerland.
Janko TackmannDepartment of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.
Robin TeconDepartment of Fundamental Microbiology, University of Lausanne, Lausanne, Switzerland.
Giovanni Stefano UgoliniInstitute of Environmental Engineering, ETH Zürich, Zürich, Switzerland.
Jordan VacheronDepartment of Fundamental Microbiology, University of Lausanne, Lausanne, Switzerland.ORCID 0000-0003-0031-1338
Jan Roelof van der MeerDepartment of Fundamental Microbiology, University of Lausanne, Lausanne, Switzerland.ORCID 0000-0003-1485-3082
Evangelia VayenaLaboratory of Computational Systems Biotechnology, EPF Lausanne, Lausanne, Switzerland.
Pascale VonaeschDepartment of Fundamental Microbiology, University of Lausanne, Lausanne, Switzerland.
Julia A VorholtInstitute of Microbiology, ETH Zürich, Zürich, Switzerland.ORCID 0000-0002-6011-4910

Funding

EC | Horizon 2020 Framework Programme (H2020) Marie Skłodowska-Curie grant agreement No 956279James McDonnell Postdoctoral Fellowship 2020-1332Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (SNF) National Centre of Competence in Research Microbiomes (grant number 180575)
6 · The paper itself

Abstract

Communities of microorganisms (microbiota) are present in all habitats on Earth and are relevant for agriculture, health, and climate. Deciphering the mechanisms that determine microbiota dynamics and functioning within the context of their respective environments or hosts (the microbiomes) is crucially important. However, the sheer taxonomic, metabolic, functional, and spatial complexity of most microbiomes poses substantial challenges to advancing our knowledge of these mechanisms. While nucleic acid sequencing technologies can chart microbiota composition with high precision, we mostly lack information about the functional roles and interactions of each strain present in a given microbiome. This limits our ability to predict microbiome function in natural habitats and, in the case of dysfunction or dysbiosis, to redirect microbiomes onto stable paths. Here, we will discuss a systematic approach (dubbed the N

Indexed as

MicrobiotaDysbiosisHumansfocal strainsinoculantsmicrobiome developmentmicrobiotamodelingsystems’ analysis

Identifiers

PMID37947420
PMCPMC10732080

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.