ArticleJournal of the American Heart Association2023
Association Between a First-Degree Family History and Self-Reported Personal History of Obesity, Diabetes, and Heart and Blood Conditions: Results From the All of Us Research Program.
Article in Journal of the American Heart Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Who cites it
17 citing papers in PubMed, 20 citations in OpenAlex.
- Associations of the atherogenic index of plasma and its modified indices with the incidence and progression of cardiometabolic multimorbidity in individuals with cardiovascular-kidney-metabolic syndrome stages 0-3: a prospective cohort study.Cardiovascular diabetology · 2026Article
- Screening, Diagnosis, Evaluation, and Staging of Obesity in Adults: Standards of Care in Overweight and Obesity-2026.BMJ open diabetes research & care · 2026Review
- Family history of cardiovascular disease and its modifiable risk factors and association with offspring risk profile.International journal of cardiology. Cardiovascular risk and prevention · 2026Article
- Analysis of morbid obese diabetic and non-diabetic patients: clinical and social characteristics, habits and workup to undergo bariatric surgery in Lombardy, Italy.Acta diabetologica · 2026Article
- Evaluating the impact of family history and polygenic risk scores on cardiometabolic disease risk.BMC medicine · 2026Article
- Returning value to communities from the All of Us Research Program through the lens of social determinants of health and ethical, legal, and social implications.International journal for equity in health · 2026Review
- Alpha-7 nicotinic acetylcholine receptor: targeting the interplay between inflammation, renin-angiotensin aldosterone system, and nervous system for the novel treatment of heart failure.Frontiers in pharmacology · 2026Review
- Investigation of the degree of family history of diabetes in different clusters of newly diagnosed type 2 diabetes in Thailand.Annals of medicine · 2025Article
- Comparative Analysis of Gender-Specific Patterns of Traditional Coronary Artery Disease Risk Factors and QRISK3 Scores in First-Degree Relatives of Coronary Artery Disease Patients.Journal of research in health sciences · 2025Article
- A Research Roadmap to Address the Heterogeneity of Diabetes and Advance Precision Medicine.The Journal of clinical endocrinology and metabolism · 2025Review
- Article
- Beyond behaviors: do biological intermediates improve lifestyle scoring for blood pressure?Frontiers in cardiovascular medicine · 2025Article
- Effects of family history and sex on diabetes-related outcome in type 2 diabetes - Analysis from the tyrolean diabetes registry.PloS one · 2025Article
- Health Care Providers' Perspectives on Factors Influencing Diabetes Management Among Thai Pregnant Women.Women's health reports (New Rochelle, N.Y.) · 2025Article
- A comparison of family health history of breast cancer, colorectal cancer, and diabetes in self-reported survey and electronic health records data, All of Us Research Program.Genetics in medicine open · 2025Article
- Family History of Arthritis, Osteoporosis, and Carpal Tunnel Syndrome and Risk of These Conditions Among US Adults.Arthritis care & research · 2024Article
- Update to the essential genomic nursing competencies and outcome indicators.Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing · 2024Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundFamily history reflects the complex interplay of genetic susceptibility and shared environmental exposures and is an important risk factor for obesity, diabetes, and heart and blood conditions (ODHB). However, the overlap in family history associations between various ODHBs has not been quantified. METHODS AND
resultsWe assessed the association between a self-reported family history of ODHBs and their risk in the adult population (age ≥20 years) of the AoU (All of Us) Research Program, a longitudinal cohort study of diverse participants across the United States. We conducted a family history-wide association study to systematically assess the association of a first-degree family history of 15 ODHBs in AoU. We performed stratified analyses based on racial and ethnic categories, education, household income and gender minority status, and quantified associations by type of affected relatives. Of 125 430 participants, 76.8% reported a first-degree family history of any ODHB, most commonly hypertension (n=64 982, 51.8%), high cholesterol (49 753, 39.7%), and heart attack (29 618, 23.6%). We use the FamWAS method to estimate 225 familial associations among 15 ODHBs. The results include overlapping associations between family history of different types of cardiometabolic conditions (such as type 2 diabetes and coronary artery disease), and their risk factors (obesity, hypertension), where adults with a family history of 1 ODHB exhibited 1.1 to 5.6 times (1.5, on average) the odds of having a different ODHB.
conclusionsOur findings inform the utility of family history data as a risk assessment and screening tool for the prevention of ODHBs and to provide additional insights into shared risk factors and pathogenic mechanisms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.