Evidence map›Paper›PMID 37946856›Full record

ArticleComputers & chemical engineering2023

Computational fluid dynamics modeling of aerosol particle transport through lung airway mucosa.

Blake A Bartlett, Yu Feng, Catherine A Fromen, Ashlee N Ford Versypt

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Computers & chemical engineering, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. European respiratory review : an official journal of the European Respiratory Society · 2024
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Blake A BartlettSchool of Chemical Engineering, Oklahoma State University, Stillwater, OK 74078, USA.
Yu FengSchool of Chemical Engineering, Oklahoma State University, Stillwater, OK 74078, USA.
Catherine A FromenDepartment of Chemical & Biomolecular Engineering, University of Delaware, Newark, DE 19716, USA.
Ashlee N Ford VersyptSchool of Chemical Engineering, Oklahoma State University, Stillwater, OK 74078, USA.

Funding

Quantitative Systems Biomedicine and Pharmacology for Multiscale Tissue DamageR35GM133763 · NIGMS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI Ashlee Nicole Ford Versypt · 2019 to 2026
$2.7M
NIGMS NIH HHS R35 GM133763
6 · The paper itself

Abstract

Delivery of aerosols to the lung can treat various lung diseases. However, the conducting airways are coated by a protective mucus layer with complex properties that make this form of delivery difficult. Mucus is a non-Newtonian fluid and is cleared from the lungs over time by ciliated cells. Further, its gel-like structure hinders the diffusion of particles through it. Any aerosolized treatment of lung diseases must penetrate the mucosal barrier. Using computational fluid dynamics, a model of the airway mucus and periciliary layer was constructed to simulate the transport of impacted aerosol particles. The model predicts the dosage fraction of particles of a certain size that penetrate the mucus and reach the underlying tissue, as well as the distance downstream of the dosage site where tissue concentration is maximized. Reactions that may occur in the mucus are also considered, with simulated data for the interaction of a model virus and an antibody.

Indexed as

DiffusionInhaled particlesLung-aerosol dynamicsMucociliary clearanceNanoparticles

Identifiers

PMID37946856
PMCPMC10634618

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.