ArticleWorld journal of clinical cases2023
Congenital leukemia: A case report and review of literature.
Article in World journal of clinical cases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Extreme hyperleukocytosis and blueberry muffin skin lesions as the initial presentation of neonatal leukemia: a case report.BMC pediatrics · 2026Article
- A Transient "Blueberry Muffin" Rash in a Neonate with Acute Myeloid Leukemia: A Case Report and Review of the Literature.The Journal of clinical and aesthetic dermatology · 2026Article
- Ventilatory support in neonates with cancer: balancing oxygen and oncologic stability.Annals of medicine and surgery (2012) · 2025Article
- Congenital Leukemia: Presentation of Three Cases.Cureus · 2025Article
- Congenital Acute Lymphoblastic Leukaemia with Hyperleucocytosis in a Full-Term Neonate: A Case Report.Case reports in oncologyArticle
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute leukemia in newborns is also known as neonatal or congenital leukemia (CL) and is a rare disease with an incidence rate of 1-5 per 1000000 live births. After birth, infants with CL exhibit infiltrative cutaneous nodules, hepatosplenomegaly, thrombocytopenia, and immature leukocytes in the peripheral blood. These symptoms are frequently accompanied by congenital abnormalities including trisomy 21, trisomy 9, trisomy 13, or Turner syndrome. Despite significant advances in disease management, the survival rate is approximately 25% at 2 years. CASE SUMMARY: Here, we document a case of trisomy 21-related acute myeloid leukemia (AML) in a female neonate. The baby was sent to the neonatal intensive care unit because of anorexia, poor responsiveness, and respiratory distress. She was diagnosed with AML based on bone marrow aspiration and immunophenotyping. Genetic sequencing identified a mutation in the
conclusionsThe newborn infant was diagnosed with trisomy 21-related AML. Genetic sequencing identified a mutation in the
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