Evidence map›Paper›PMID 37946686›Full record

ArticleAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics2024

Predicting ADHD in alcohol dependence using polygenic risk scores for ADHD.

Kejal H S Patel, G Bragi Walters, Hreinn Stefánsson, Kári Stefánsson, Franziska Degenhardt, Markus Nothen, Tracey Van Der Veen, Ditte Demontis, Anders Borglum, Mark Kristiansen and 2 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 4 countries.

Kejal H S PatelMolecular Psychiatry Laboratory, Division of Psychiatry, University College London, London, UK.ORCID 0000-0003-4730-8566
G Bragi WaltersdeCODE genetics/Amgen, Reykjavik, Iceland.ORCID 0000-0002-5415-6487
Hreinn StefánssondeCODE genetics/Amgen, Reykjavik, Iceland.
Kári StefánssondeCODE genetics/Amgen, Reykjavik, Iceland.
Franziska DegenhardtDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, LVR Klinikum Essen, University of Duisburg-Essen, Essen, Germany.
Markus NothenInstitute of Human Genetics, University of Bonn, School of Medicine & University Hospital, Bonn, Germany.
Tracey Van Der VeenMolecular Psychiatry Laboratory, Division of Psychiatry, University College London, London, UK.
Ditte DemontisDepartment of Biomedicine-Human Genetics, Aarhus University, Aarhus, Denmark.
Anders BorglumDepartment of Biomedicine-Human Genetics, Aarhus University, Aarhus, Denmark.
Mark KristiansenUniversity College London Genomics, Institute of Child Health, University College London, London, UK.
Nicholas J BassMolecular Psychiatry Laboratory, Division of Psychiatry, University College London, London, UK.
Andrew McQuillinMolecular Psychiatry Laboratory, Division of Psychiatry, University College London, London, UK.ORCID 0000-0003-1567-2240
University College London · GBdeCODE Genetics (Iceland) · ISAarhus University · DKUniversity of Bonn · DEGenomics England · GB

Funding

2/7 Psychiatric Genomics Consortium: Advancing Discovery and ImpactR01MH124851 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI BOERGLUM, ANDERS, DAVIS, LEA K · 2021 to 2025
$5.4M
NIH HHSNIMH NIH HHS R01 MH124851
6 · The paper itself

Abstract

Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder with a high degree of comorbidity, including substance misuse. We aimed to assess whether ADHD polygenic risk scores (PRS) could predict ADHD diagnosis in alcohol dependence (AD). ADHD PRS were generated for 1223 AD subjects with ADHD diagnosis information and 1818 healthy controls. ADHD PRS distributions were compared to evaluate the differences between healthy controls and AD cases with and without ADHD. We found increased ADHD PRS means in the AD cohort with ADHD (mean 0.30, standard deviation (SD) 0.92; p = 3.9 × 10

Indexed as

AlcoholismAttention Deficit Disorder with HyperactivityGenetic Risk ScoreAdultCase-Control StudiesComorbidityFemaleHumansMaleMiddle AgedADHDalcohol dependenceco‐morbidityco‐occurring disorderspolygenic risk scores

Identifiers

PMID37946686
PMCPMC11076171
OpenAlexW4388570487

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.