Evidence map›Paper›PMID 37946470›Full record

ArticleJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2023

Bornyl acetate extracted from Sharen () inhibits proliferation, invasion and induces apoptosis by suppressing phosphatidylinositol-3-kinase/protein kinase B signaling in colorectal cancer.

L I Xiaohua, Duan Zhihang, Yue Jianjun, Zhang Yongyu, L I Yihang, Liu Shifang, Nie Qu, Yang Depo, Zhang Lixia

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. A Comparison between BulgarianMolecules (Basel, Switzerland) · 2024
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

L I XiaohuaSchool of Traditional Dai-Thai Medicine, West Yunnan University of Apllied Science, Jinghong 666100, China.
Duan ZhihangSchool of Traditional Dai-Thai Medicine, West Yunnan University of Apllied Science, Jinghong 666100, China.
Yue JianjunSchool of Traditional Dai-Thai Medicine, West Yunnan University of Apllied Science, Jinghong 666100, China.
Zhang YongyuSchool of Traditional Dai-Thai Medicine, West Yunnan University of Apllied Science, Jinghong 666100, China.
L I YihangInstitute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Jinghong 666100, China.
Liu ShifangInstitute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Jinghong 666100, China.
Nie QuSchool of Traditional Dai-Thai Medicine, West Yunnan University of Apllied Science, Jinghong 666100, China.
Yang DepoInstitute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Jinghong 666100, China.
Zhang LixiaYunnan Branch, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Yunnan Key Laboratory of Southern Medicine Utilization, Jinghong 666100, China.
Yunnan University of Traditional Chinese Medicine · CNChinese Academy of Medical Sciences & Peking Union Medical College · CN

Funding

Characteristic Dai-Medicine Resource ERC of West Yunnan University of Apllied Science 2022KYPT0004Major Science and Technology Special Plan of Yunnan Province 202102AA100020Scientific and Technological Talents and Platform Plan of Yunnan Province 202105AG070011Study on the symbiotic system of Sharen Fructus AmomiUnderground Ecological Planting Technology and Base Establishment of Sharen (Fructus Amomi) in the forest 2017YFC1701102weevil pollination and its "push-pull" pollination mechanism 82260736
6 · The paper itself

Abstract

objectiveTo investigate the antitumor effects of bornyl acetate (BA) isolated from Sharen (

methodsSW480 and HT29 cells were treated with increasing doses of BA in order to determine its antitumor effects

resultsBA showed anti-CRC tumor activities

conclusionsThe results demonstrated that BA exerts antitumor effects by suppressing the PI3K/AKT pathway, with low toxicity. Thus, BA might be a potential novel therapeutic agent for CRC.

Indexed as

Colorectal NeoplasmsProto-Oncogene Proteins c-aktAnimalsApoptosisCamphanesCell Line, TumorCell MovementCell ProliferationHumansMicePhosphatidylinositol 3-KinasePhosphatidylinositol 3-KinasesPhosphatidylinositolsbornyl acetateCamphanesPhosphatidylinositol 3-KinasePhosphatidylinositol 3-KinasesPhosphatidylinositolsProto-Oncogene Proteins c-aktbornyl acetatecolorectal neoplasmsphosphatidylinositol 3-kinaseprotein kinases Bsignal transduction

Identifiers

PMID37946470
PMCPMC10623251
OpenAlexW4388578731

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.