Evidence map›Paper›PMID 37946341›Full record

ArticleMedicinal chemistry (Shariqah (United Arab Emirates))2024

Synthesis and Structural Activity Relationship Study of Ursolic Acid Derivatives as Antitubercular Agent.

Sadhna Vishwakarma, Santosh K Srivastava, Naveen K Khare, Shiwa Chaubey, Vinita Chaturvedi, Priyanka Trivedi, Sana Khan, Feroz Khan

Abstract read
PubMed Publisher
In one paragraph

Article in Medicinal chemistry (Shariqah (United Arab Emirates)), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sadhna VishwakarmaDepartment of Medicinal Chemistry, CSIR-Central Institute of Medicinal and Aromatic Plants (CIMAP), Lucknow, 226015, India.
Santosh K SrivastavaDepartment of Medicinal Chemistry, CSIR-Central Institute of Medicinal and Aromatic Plants (CIMAP), Lucknow, 226015, India.
Naveen K KhareDepartment of Chemistry, University of Lucknow, Lucknow, 226007, India.
Shiwa ChaubeyDepartment of Chemistry, University of Lucknow, Lucknow, 226007, India.
Vinita ChaturvediDivision of Biochemistry and Structural Biology, CSIR-Central Drug Research Institute, Lucknow, 226031, India.
Priyanka TrivediDivision of Biochemistry and Structural Biology, CSIR-Central Drug Research Institute, Lucknow, 226031, India.
Sana KhanDepartment of Metabolic and Structural Biology, CSIR-Central Institute of Medicinal and Aromatic Plants (CIMAP), Lucknow, 226015, India.
Feroz KhanDepartment of Metabolic and Structural Biology, CSIR-Central Institute of Medicinal and Aromatic Plants (CIMAP), Lucknow, 226015, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe chemical transformation of ursolic acid (UA) into novel C-3 aryl ester derivatives and

backgroundUA is a natural pentacyclic triterpenoid with many pharmacological properties. Semisynthetic UA analogs have demonstrated enhanced anticancer, antimalarial, and antifilarial properties in our previous studies.

methodsThe C-30 carboxylic group of previously isolated UA was protected, and various C-3 aryl ester derivatives were semi-synthesized. The agar dilution method was used to evaluate the

resultsThe derivative 3-O-(2-amino,3-methyl benzoic acid)-ethyl ursolate (UA-1H) was the most active among the eight derivatives (MIC1 2.5 μg/mL) against Mtb H

conclusionThe ursolic acid derivative UA-1H possesses significant

Indexed as

Antitubercular AgentsMolecular Docking SimulationMycobacterium tuberculosisTriterpenesUrsolic AcidMicrobial Sensitivity TestsMolecular StructureStructure-Activity RelationshipAntitubercular AgentsTriterpenesUrsolic Acidantituberculareucalyptus tereticornisin silico docking.in vitrotriterpenoidUrsolic acid

Identifiers

PMID37946341

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.