ArticleGenome biology2023
A genome catalog of the early-life human skin microbiome.
Article in Genome biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- VITALITY - a longitudinal cohort established to assess the role of postnatal vitamin D supplementation in atopic disease and immune health.European journal of epidemiology · 2026Article
- Shotgun Metagenomics Reveals Skin Microbiome Composition and Function in Infant Atopic Disease.Allergy · 2026Article
- Genomic landscape of the human vaginal microbiome is linked to host genetics and population of origin.Nature genetics · 2026Article
- Permissive skin microbiomes in WHIM syndrome: HPV and pathogen expansion.The Journal of investigative dermatology · 2026Article
- The human skin virome: Ecological dynamics, aberrant profiles, and therapeutic opportunities.Cell host & microbe · 2026Review
- Functional divergence of the gut microbiome associated with lifestyle and helminth infection in Indigenous Peninsular Malaysian.Research square · 2026Article
- Skin microbiome and cutaneous aging mechanisms and clinical implications.Frontiers in microbiology · 2026Review
- Variation in the early-life interdigital skin microbiota of lambs in a commercial sheep flock.Frontiers in veterinary science · 2026Article
- Article
- Comparative genomic analysis of a metagenome-assembled genome reveals distinctive symbiotic traits in a Mucoromycotina fine root endophyte arbuscular mycorrhizal fungus.BMC genomics · 2025Article
- Restoration of the human skin microbiome following immune recovery after hematopoietic stem cell transplantation.Cell host & microbe · 2025Article
- Article
- Intraspecies dynamics underlie the apparent stability of two important skin microbiome species.Cell host & microbe · 2025Article
- Clinical translation of microbiome research.Nature medicine · 2025Review
- Exploring the Skin Microbiome in Central Centrifugal Cicatricial Alopecia.JAMA dermatology · 2025Article
- Skin microbiome and dermatologic disorders.The Journal of clinical investigation · 2025Review
- Previously hidden intraspecies dynamics underlie the apparent stability of two important skin microbiome species.bioRxiv : the preprint server for biology · 2025Article
- The human microbiome in clinical translation: from bench to bedside.Frontiers in microbiology · 2025Review
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Authors and funding
22 authors.
Funding
Abstract
backgroundMetagenome-assembled genomes have greatly expanded the reference genomes for skin microbiome. However, the current reference genomes are largely based on samples from adults in North America and lack representation from infants and individuals from other continents.
resultsHere we use deep shotgun metagenomic sequencing to profile the skin microbiota of 215 infants at age 2-3 months and 12 months who are part of the VITALITY trial in Australia as well as 67 maternally matched samples. Based on the infant samples, we present the Early-Life Skin Genomes (ELSG) catalog, comprising 9483 prokaryotic genomes from 1056 species, 206 fungal genomes from 13 species, and 39 eukaryotic viral sequences. This genome catalog substantially expands the diversity of species previously known to comprise human skin microbiome and improves the classification rate of sequenced data by 21%. The protein catalog derived from these genomes provides insights into the functional elements such as defense mechanisms that distinguish early-life skin microbiome. We also find evidence for microbial sharing at the community, bacterial species, and strain levels between mothers and infants.
conclusionsOverall, the ELSG catalog uncovers the skin microbiome of a previously underrepresented age group and population and provides a comprehensive view of human skin microbiome diversity, function, and development in early life.
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