Evidence map›Paper›PMID 37946205›Full record

ArticleCardiovascular diabetology2023

Association between insulin resistance and uncontrolled hypertension and arterial stiffness among US adults: a population-based study.

Liao Tan, Yubo Liu, Jie Liu, Guogang Zhang, Zhaoya Liu, Ruizheng Shi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiovascular diabetology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed, 1 pooled it
25.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 1 synthesis or guideline pooled it, 114 citations in OpenAlex.

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21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Liao Tan *Department of Cardiology, Third Xiangya Hospital, Central South University, Hunan, China.
Yubo Liu *Department of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Jie LiuDepartment of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Guogang ZhangDepartment of Cardiology, Third Xiangya Hospital, Central South University, Hunan, China.
Zhaoya LiuDepartment of the Geriatrics, Third Xiangya Hospital, Central South University, Hunan, China. liuzhaoya@csu.edu.cn.
Ruizheng ShiDepartment of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China. xyshiruizheng@csu.edu.cn.
Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrior research has established the correlation between insulin resistance (IR) and hypertension. While the association between triglyceride-glucose (TyG) index, a reliable surrogate marker of IR, and uncontrolled hypertension as well as arterial stiffness among individuals with hypertension remains undisclosed.

methodsIn this study, a total of 8513 adults diagnosed with hypertension from the National Health and Nutrition Examination Survey 1999-2018 were included. The primary outcome of the study are arterial stiffness (represented with estimated pulse wave velocity, ePWV) and uncontrolled hypertension. Logistic regression model, subgroup analysis, restricted cubic spine, and smooth curve fitting curve were conducted to evaluate the association between the IR indicators and uncontrolled hypertension and arterial stiffness in individuals with hypertension.

resultsAmong included participants, the overall prevalence of uncontrolled hypertension was 54.3%. After adjusting for all potential covariates, compared with the first quartile of TyG index, the risk of uncontrolled hypertension increased about 28% and 49% for participants in the third quartile (OR, 1.28; 95% CI 1.06-1.52) and the fourth quartile (OR, 1.49; 95% CI 1.21-1.89) of TyG index, respectively. The higher OR of TyG index was observed in participants taking antihypertensive medication [fourth quartile versus first quartile (OR, 2.03; 95% CI 1.37-3.11)]. Meanwhile, we explored the potential association between TyG index and arterial stiffness and found that TyG index was significantly associated with increased arterial stiffness (β for ePWV, 0.04; 95% CI 0.00-0.08; P = 0.039). However, traditional IR indicator HOMA-IR showed no significant positive correlation to uncontrolled hypertension as well as arterial stiffness in US adults with hypertension.

conclusionElevated levels of the TyG index were positive associated with prevalence of uncontrolled hypertension and arterial stiffness among US adults with hypertension.

Indexed as

HypertensionInsulin ResistanceVascular StiffnessAdultBiomarkersBlood GlucoseGlucoseHumansNutrition SurveysPulse Wave AnalysisTriglyceridesBiomarkersBlood GlucoseGlucoseTriglyceridesArterial stiffnessHypertensionInsulin resistanceNHANESTriglyceride-glucose index

Identifiers

PMID37946205
PMCPMC10637002
OpenAlexW4388520307

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.