Evidence map›Paper›PMID 37946192›Full record

ArticleJournal of nanobiotechnology2023

Aptamer-based self-assembled nanomicelle enables efficient and targeted drug delivery.

Ganghui Chen, Dongsheng Mao, Xuan Wang, Jingqi Chen, Chao Gu, Shuqin Huang, Yu Yang, Fang Zhang, Weihong Tan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Aptamers' Potential to Fill Therapeutic and Diagnostic Gaps.Pharmaceuticals (Basel, Switzerland) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Ganghui ChenInstitute of Molecular Medicine (IMM), Shanghai Jiao Tong University School of Medicine, Renji Hospital, College of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China.
Dongsheng MaoInstitute of Molecular Medicine (IMM), Shanghai Jiao Tong University School of Medicine, Renji Hospital, College of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China.
Xuan WangInstitute of Molecular Medicine (IMM), Shanghai Jiao Tong University School of Medicine, Renji Hospital, College of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China.
Jingqi ChenInstitute of Molecular Medicine (IMM), Shanghai Jiao Tong University School of Medicine, Renji Hospital, College of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China.
Chao GuInstitute of Molecular Medicine (IMM), Shanghai Jiao Tong University School of Medicine, Renji Hospital, College of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China.
Shuqin HuangCollege of Biological Science and Engineering, Fuzhou University, Fuzhou, 350108, People's Republic of China.
Yu YangInstitute of Molecular Medicine (IMM), Shanghai Jiao Tong University School of Medicine, Renji Hospital, College of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China. yuyang@shsmu.edu.cn.
Fang ZhangCollege of Biological Science and Engineering, Fuzhou University, Fuzhou, 350108, People's Republic of China. fangzh921@fzu.edu.cn.
Weihong TanInstitute of Molecular Medicine (IMM), Shanghai Jiao Tong University School of Medicine, Renji Hospital, College of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China.
Renji Hospital · CNFuzhou University · CNShanghai Jiao Tong University · CN

Funding

"Clinic Plus" Outstanding Project 2021ZYB009National Natural Science Foundation of China 22277072National Research Programs of China 2022YFA1206500
6 · The paper itself

Abstract

Nucleic acid aptamer-based nanomicelles have great potential for nanomedicine and nanotechnology applications. However, amphiphilic aptamer micelles are known to be inherently unstable upon interaction with cell membranes in the physiological environment, thus potentially compromising their specific targeting against cancer cells. This flaw is addressed in the present work which reports a superstable micellar nanodelivery system as an amphiphilic copolymer self-assembled micelle composed of nucleic acid aptamer and polyvalent hydrophobic poly(maleic anhydride-alt-1-octadecene) (C

Indexed as

NeoplasmsNucleic AcidsCell Line, TumorDrug CarriersDrug Delivery SystemsHumansMicellesOligonucleotidesPolymersDrug CarriersMicellesNucleic AcidsOligonucleotidesPolymersAptamer micellesSelf-assemblySpecific cell recognition

Identifiers

PMID37946192
PMCPMC10634091
OpenAlexW4388531817

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.