ArticleNature neuroscience2023
Topological analysis of sharp-wave ripple waveforms reveals input mechanisms behind feature variations.
Article in Nature neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Article
- Arousal state modulates human hippocampal ripples.bioRxiv : the preprint server for biology · 2026Article
- Inroads into epilepsy through high-frequency oscillations: Achievements and benchmark areas for improvement.Epilepsia · 2026Review
- Review
- A hippocampal 'sharp-wave sleep' state that is dissociable from cortical sleep.Nature neuroscience · 2026Article
- Consensus-based Sharp-Wave Ripple detection and its application in an alcohol administration model.Frontiers in systems neuroscience · 2026Article
- Hippocampal ripple diversity organizes neuronal reactivation dynamics in the offline brain.Neuron · 2025Article
- Spatiotemporal patterns differentiate hippocampal sharp-wave ripples from interictal epileptiform discharges in mice and humans.Nature communications · 2025Article
- Ripple contributions to human memory: making the spiking content count.Nature reviews. Neuroscience · 2025Review
- Behavioral Timing of Interictal Spikes, But Not Rate, Correlates with Impaired Working Memory Performance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Cooperative actions of interneuron families support the hippocampal spatial code.Science (New York, N.Y.) · 2025Article
- Ultraslow serotonin oscillations in the hippocampus delineate substates across NREM and waking.eLife · 2025Article
- Article
- The role of electroencephalography in epilepsy research-From seizures to interictal activity and comorbidities.Epilepsia · 2025Review
- Differential contributions of CA3 and entorhinal cortex inputs to ripple patterns in the hippocampus.iScience · 2025Article
- Electroanatomy of hippocampal activity patterns: theta, gamma waves, sharp wave-ripples, and dentate spikes.Frontiers in behavioral neuroscience · 2025Article
- Sleep microstructure organizes memory replay.Nature · 2025Article
- Interictal spikes during spatial working memory carry helpful or distracting representations of space and have opposing impacts on performance.bioRxiv : the preprint server for biology · 2024Article
- High frequency oscillations in human memory and cognition: a neurophysiological substrate of engrams?Brain : a journal of neurology · 2024Review
- Local field potential sharp waves with diversified impact on cortical neuronal encoding of haptic input.Scientific reports · 2024Article
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Authors and funding
6 authors.
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Abstract
The reactivation of experience-based neural activity patterns in the hippocampus is crucial for learning and memory. These reactivation patterns and their associated sharp-wave ripples (SWRs) are highly variable. However, this variability is missed by commonly used spectral methods. Here, we use topological and dimensionality reduction techniques to analyze the waveform of ripples recorded at the pyramidal layer of CA1. We show that SWR waveforms distribute along a continuum in a low-dimensional space, which conveys information about the underlying layer-specific synaptic inputs. A decoder trained in this space successfully links individual ripples with their expected sinks and sources, demonstrating how physiological mechanisms shape SWR variability. Furthermore, we found that SWR waveforms segregated differently during wakefulness and sleep before and after a series of cognitive tasks, with striking effects of novelty and learning. Our results thus highlight how the topological analysis of ripple waveforms enables a deeper physiological understanding of SWRs.
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