Evidence map›Paper›PMID 37946042›Full record

ArticleNature aging2023

The CRTC-1 transcriptional domain is required for COMPASS complex-mediated longevity in C. elegans.

Carlos G Silva-García, Laura I Láscarez-Lagunas, Katharina Papsdorf, Caroline Heintz, Aditi Prabhakar, Christopher S Morrow, Lourdes Pajuelo Torres, Arpit Sharma, Jihe Liu, Monica P Colaiácovo and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature aging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Carlos G Silva-GarcíaDepartment of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Harvard University, Boston, MA, USA.ORCID 0000-0002-0434-7787
Laura I Láscarez-LagunasDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Katharina PapsdorfDepartment of Genetics, Stanford University, Stanford, CA, USA.
Caroline HeintzDepartment of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Harvard University, Boston, MA, USA.
Aditi PrabhakarDepartment of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Harvard University, Boston, MA, USA.ORCID 0000-0002-6024-4600
Christopher S MorrowDepartment of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Harvard University, Boston, MA, USA.
Lourdes Pajuelo TorresDepartment of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Harvard University, Boston, MA, USA.ORCID 0000-0002-6578-6687
Arpit SharmaDepartment of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Harvard University, Boston, MA, USA.
Jihe LiuHarvard Chan Bioinformatics Core, Harvard T. H. Chan School of Public Health, Harvard University, Boston, MA, USA.
Monica P ColaiácovoDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Anne BrunetDepartment of Genetics, Stanford University, Stanford, CA, USA.ORCID 0000-0002-4608-6845
William B MairDepartment of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Harvard University, Boston, MA, USA. wmair@hsph.harvard.edu.ORCID 0000-0002-0661-1342
Boston University · USHarvard University · USStanford University · US

Funding

Synaptonemal Complex Assembly and Function in MeiosisR01GM072551 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI Monica P Colaiacovo · 2005 to 2026
$7.5M
Mechanisms Specific to the Beneficial Effects of Dietary RestrictionR01AG044346 · NIA · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI William B Mair · 2013 to 2026
$3.8M
Link between epigenetic modifiers and fat metabolism for healthy agingR01AG054201 · NIA · STANFORD UNIVERSITY · PI BRUNET, ANNE, MAIR, WILLIAM B · 2016 to 2020
$2.2M
Cell Non-autonomous Regulation of Aging via Neuronal TORC1R01AG059595 · NIA · HARVARD SCHOOL OF PUBLIC HEALTH · PI MAIR, WILLIAM B · 2018 to 2022
$2.0M
Reversing Loss of Metabolic Homeostasis to Ameliorate Alzheimer's Disease PathogenicityR01AG067106 · NIA · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI MAIR, WILLIAM B · 2020 to 2024
$2.0M
Targeting RNA homeostasis to promote healthy agingR01AG051954 · NIA · HARVARD SCHOOL OF PUBLIC HEALTH · PI MAIR, WILLIAM B · 2017 to 2020
$1.7M
Molecular mechanisms linking epigenetic changes to longevityR00AG065508 · NIA · BROWN UNIVERSITY · PI SILVA-GARCIA, CARLOS GIOVANNI · 2023 to 2025
$742k
Molecular Mechanisms Linking Epigenetic Changes to LongevityK99AG065508 · NIA · HARVARD SCHOOL OF PUBLIC HEALTH · PI SILVA-GARCIA, CARLOS GIOVANNI · 2020 to 2022
$387k
NIA NIH HHS K99 AG065508NIA NIH HHS R00 AG065508NIA NIH HHS R01 AG044346NIA NIH HHS R01 AG051954NIA NIH HHS R01 AG054201NIA NIH HHS R01 AG059595NIA NIH HHS R01 AG067106NIGMS NIH HHS R01 GM072551
6 · The paper itself

Abstract

Loss of function during aging is accompanied by transcriptional drift, altering gene expression and contributing to a variety of age-related diseases. CREB-regulated transcriptional coactivators (CRTCs) have emerged as key regulators of gene expression that might be targeted to promote longevity. Here we define the role of the Caenorhabditis elegans CRTC-1 in the epigenetic regulation of longevity. Endogenous CRTC-1 binds chromatin factors, including components of the COMPASS complex, which trimethylates lysine 4 on histone H3 (H3K4me3). CRISPR editing of endogenous CRTC-1 reveals that the CREB-binding domain in neurons is specifically required for H3K4me3-dependent longevity. However, this effect is independent of CREB but instead acts via the transcription factor AP-1. Strikingly, CRTC-1 also mediates global histone acetylation levels, and this acetylation is essential for H3K4me3-dependent longevity. Indeed, overexpression of an acetyltransferase enzyme is sufficient to promote longevity in wild-type worms. CRTCs, therefore, link energetics to longevity by critically fine-tuning histone acetylation and methylation to promote healthy aging.

Indexed as

Caenorhabditis elegansLongevityAnimalsCaenorhabditis elegans ProteinsEpigenesis, GeneticHistonesTrans-ActivatorsTranscription FactorsCaenorhabditis elegans ProteinsCRTC-1 protein, C elegansHistonesTrans-ActivatorsTranscription Factors

Identifiers

PMID37946042
PMCPMC10645585
OpenAlexW4388523237

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.