Evidence map›Paper›PMID 37946003›Full record

ArticleArchives of microbiology2023

Cytotoxic activity of cordycepin produced by marine-derived fungus Emericella sp. against HT29 human colon cancer cell lines.

Elin Julianti, Muhammad Azhari, Marlia Singgih, Fitri Siti Dzurriyyah Aminah, Masteria Yunovilsa Putra, Jianyu Lin, Atsushi Kimishima, Masayoshi Arai

Abstract read
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In one paragraph

Article in Archives of microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 81% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Elin JuliantiDepartment of Pharmacochemistry, School of Pharmacy, Bandung Institute of Technology, Bandung, Indonesia. elin_julianti@itb.ac.id.
Muhammad AzhariDepartment of Pharmacochemistry, School of Pharmacy, Bandung Institute of Technology, Bandung, Indonesia.
Marlia SinggihDepartment of Pharmacochemistry, School of Pharmacy, Bandung Institute of Technology, Bandung, Indonesia.
Fitri Siti Dzurriyyah AminahDepartment of Pharmacochemistry, School of Pharmacy, Bandung Institute of Technology, Bandung, Indonesia.
Masteria Yunovilsa PutraResearch Center for Vaccine and Drugs, Research Organisation for Health, National Research and Innovation (BRIN), Cibinong, Indonesia.
Jianyu LinLaboratory of Natural Products for Drug Discovery, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.
Atsushi KimishimaLaboratory of Natural Products for Drug Discovery, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.
Masayoshi AraiLaboratory of Natural Products for Drug Discovery, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.
Bandung Institute of Technology · IDOsaka University · JP

Funding

Excellence Higher Education Institution Research 2020 DIKTI, Directorate of Higher Education of the Ministry of Research, Technology and Higher Education of the Republic of Indonesia No. 2/AMD/EI/KP.PTNBH/2020Grant-in-Aid for Scientific Research B from the Japan Society for the Promotion of Science (JSPS) No. 21H02069Research Support Project for Life Science and Drug Discovery (Basis for Supporting Innovative Drug Discovery and Life Science Research (BINDS)) from AMED JP23ama121054
6 · The paper itself

Abstract

Colorectal cancer accounted for the third most common cancer in the world. The search for new drug candidates that can be used for colorectal cancer treatment from marine-derived fungi, Emericella sp. The present study was performed to isolate the cytotoxic compound from Emericella sp. The isolation method was carried out by using a combination of chromatographic techniques to afford compound 1. The cytotoxic activity and the exosome production property were determined by using proliferation and luciferase assay against HT29 CD63 Nluc cells, respectively. The chemical structure of compound 1 was identified as cordycepin based on spectroscopy methods such as mass spectrometry and nuclear magnetic resonance (1D and 2D NMR) analyses and comparison with authentic spectral data. The biological activity assay showed that cordycepin exhibited cytotoxic activity with an IC

Indexed as

Antineoplastic AgentsColonic NeoplasmsColorectal NeoplasmsEmericellaAspergillusCell Line, TumorDeoxyadenosinesFungiHumansLuciferasesMolecular StructureAntineoplastic AgentscordycepinDeoxyadenosinesLuciferasesColorectal cancerCordycepinCytotoxic activityEmericella sp.Exosome production

Identifiers

PMID37946003
OpenAlexW4388550976

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.