Evidence map›Paper›PMID 37945903›Full record

ArticleNature genetics2023

Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants.

Anqi Wang, Jiayi Shen, Alex A Rodriguez, Edward J Saunders, Fei Chen, Rohini Janivara, Burcu F Darst, Xin Sheng, Yili Xu, Alisha J Chou and 282 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature genetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01221168 (ProGene), which is not on this map. Cited by 112 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
112citing papers in PubMed, 4 pooled it
41.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01221168 recruitingnot on this map

ProGene: Etude Genetique et Epidemiologique du Cancer de la Prostate Familial

TypeobservationalSponsorCentre de Recherche sur les Pathologies ProstatiquesRan1996 to 2026Enrolled10,000ConditionsProstate Cancer
3 · Its place in the literature

Who cites it

112 citing papers in PubMed, 4 syntheses or guidelines pooled it, 131 citations in OpenAlex.

  1. Pooled it
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  4. Pooled it
  5. Trial
  6. Trial
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  17. The Multiethnic Cohort: A Resource for the Study of Genetic and Nongenetic Cancer Risk across Populations.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026
    Article
  18. Article
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  20. Polygenic risk scores in cancer.Medizinische Genetik : Mitteilungsblatt des Berufsverbandes Medizinische Genetik e.V · 2026
    Article

52 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

292 authors at 20 institutions in 26 countries.

Anqi WangCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0002-0552-4642
Jiayi ShenCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0003-0701-9831
Alex A RodriguezArgonne National Laboratory, Lemont, IL, USA.
Edward J SaundersThe Institute of Cancer Research, London, UK.
Fei ChenCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Rohini JanivaraSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.ORCID 0000-0002-0634-2357
Burcu F DarstCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0002-6205-4632
Xin ShengCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Yili XuCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0001-8508-4706
Alisha J ChouCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0001-7521-6373
Sara BenllochDepartment of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.
Tokhir DadaevThe Institute of Cancer Research, London, UK.ORCID 0000-0002-8268-0438
Mark N BrookThe Institute of Cancer Research, London, UK.ORCID 0000-0002-8969-2378
Anna PlymDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.
Ali SahimiDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Thomas J HoffmanDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.ORCID 0000-0001-6893-4449
Atushi TakahashiLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.ORCID 0000-0001-7099-8767
Koichi MatsudaDepartment of Computational Biology and Medical Sciences, Laboratory of Clinical Genome Sequencing, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.ORCID 0000-0001-7292-2686
Yukihide MomozawaLaboratory for Genotyping Development, RIKEN Center of Integrative Medical Sciences, Yokohama, Japan.ORCID 0000-0001-5638-3504
Masashi FujitaLaboratory for Cancer Genomics, RIKEN Center of Integrative Medical Sciences, Yokohama, Japan.ORCID 0000-0002-1457-6233
Triin LaiskEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID 0000-0003-1501-9030
Jéssica FiguerêdoEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Kenneth MuirDivision of Population Health, Health Services Research and Primary Care, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.ORCID 0000-0001-6429-988X
Shuji ItoDepartment of Orthopaedics, Shimane University, Izumo, Japan.
Xiaoxi LiuLaboratory for Statistical and Translational Genetics, Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan.
Biobank Japan Project
Yuji UchioDepartment of Orthopaedics, Shimane University, Izumo, Japan.ORCID 0000-0002-5858-9861
Michiaki KuboRIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Yoichiro KamataniLaboratory for Statistical and Translational Genetics, Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan.ORCID 0000-0001-8748-5597
Artitaya LophatananonDivision of Population Health, Health Services Research and Primary Care, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Peggy WanDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Caroline AndrewsHarvard TH Chan School of Public Health and Division of Population Sciences, Dana Farber Cancer Institute, Boston, MA, USA.
Adriana LoriDepartment of Population Science, American Cancer Society, Kennesaw, GA, USA.
Parichoy P ChoudhurySurveillance & Health Science Department, American Cancer Society, Kennesaw, GA, USA.
Johanna SchleutkerInstitute of Biomedicine, University of Turku, Turku, Finland.ORCID 0000-0002-1863-0305
Teuvo L J TammelaDepartment of Urology, Tampere University Hospital, Tampere, Finland.
Csilla SipekyInstitute of Biomedicine, University of Turku, Turku, Finland.ORCID 0000-0002-8853-4722
Anssi AuvinenUnit of Health Sciences, Faculty of Social Sciences, Tampere University, Tampere, Finland.ORCID 0000-0003-1125-4818
Graham G GilesCancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.ORCID 0000-0003-4946-9099
Melissa C SoutheyPrecision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia.ORCID 0000-0002-6313-9005
Robert J MacInnisCancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.
Cezary CybulskiInternational Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Dominika WokolorczykInternational Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Jan LubinskiInternational Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Christopher T RentschYale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-1408-7907
Kelly ChoDivision of Aging, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Benjamin H McmahonTheoretical Biology Division, Los Alamos National Lab, Los Alamos, NM, USA.
David E NealNuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Headington, UK.
Jenny L DonovanPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Freddie C HamdyNuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.
Richard M MartinPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.ORCID 0000-0002-7992-7719
Borge G NordestgaardFaculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-1954-7220
Sune F NielsenFaculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Maren WeischerDepartment of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark.
Stig E BojesenFaculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-4061-4133
Andreas RøderCopenhagen Prostate Cancer Center, Department of Urology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.ORCID 0000-0002-0019-5333
Hein V StroombergCopenhagen Prostate Cancer Center, Department of Urology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.ORCID 0000-0002-7293-9506
Jyotsna BatraCentre for Genomics and Personalised Health, Queensland University of Technology, Brisbane, Queensland, Australia.ORCID 0000-0003-4646-6247
Suzanne ChambersUniversity of Technology, Sydney, New South Wales, Australia.
Lisa HorvathChris O'Brien Lifehouse, Camperdown, Sydney, New South Wales, Australia.ORCID 0000-0001-6842-9223
Judith A ClementsTranslational Research Institute, Brisbane, Queensland, Australia.ORCID 0000-0001-6026-1964
Wayne TillyDame Roma Mitchell Cancer Research Laboratories, University of Adelaide, Adelaide, South Australia, Australia.ORCID 0000-0003-1893-2626
Gail P RisbridgerDepartment of Anatomy and Developmental Biology, Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia.ORCID 0000-0003-3089-4028
Henrik GronbergDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.ORCID 0000-0002-1073-2753
Markus AlyDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.ORCID 0000-0002-7602-9198
Robert SzulkinDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.
Martin EklundDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.ORCID 0000-0001-5032-5266
Tobias NordstromDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.ORCID 0000-0003-4915-7546
Nora PashayanDepartment of Applied Health Research, University College London, London, UK.ORCID 0000-0003-0843-2468
Alison M DunningCentre for Cancer Genetic Epidemiology, Department of Oncology, Strangeways Laboratory, University of Cambridge, Cambridge, UK.ORCID 0000-0001-6651-7166
Maya GhoussainiOpen Targets, Wellcome Sanger Institute, Saffron Walden, UK.ORCID 0000-0002-2415-2143
Ruth C TravisCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.ORCID 0000-0002-9571-0763
Tim J KeyCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Elio RiboliDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.ORCID 0000-0001-6795-6080
Jong Y ParkDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA.ORCID 0000-0002-6384-6447
Thomas A SellersDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA.
Hui-Yi LinSchool of Public Health, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
Demetrius AlbanesDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.ORCID 0000-0001-8330-4293
Stephanie WeinsteinDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.ORCID 0000-0002-3834-1535
Michael B CookDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.
Lorelei A MucciDepartment of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Edward GiovannucciDepartment of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Sara LindstromDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
Peter KraftProgram in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.ORCID 0000-0002-4472-8103
David J HunterNuffield Department of Population Health, University of Oxford, Oxford, UK.
Kathryn L PenneyChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital/Harvard Medical School, Boston, MA, USA.
Constance TurmanProgram in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Catherine M TangenSWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Phyllis J GoodmanSWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Ian M ThompsonCHRISTUS Santa Rosa Hospital-Medical Center, San Antonio, TX, USA.
Robert J HamiltonDepartment of Surgical Oncology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.
Neil E FleshnerDepartment of Surgical Oncology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.
Antonio FinelliDivision of Urology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.
Marie-Élise ParentEpidemiology and Biostatistics Unit, Centre Armand-Frappier Santé Biotechnologie, Laval, Quebec, Canada.ORCID 0000-0002-4196-3773
Janet L StanfordDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Elaine A OstranderNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-6075-9738
Stella KoutrosDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.
Laura E Beane FreemanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.
Meir StampferChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital/Harvard Medical School, Boston, MA, USA.
Alicja WolkDivision of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-7387-6845
Niclas HåkanssonDivision of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-7673-5554
Gerald L AndrioleBrady Urological Institute in National Capital Region, Johns Hopkins University, Baltimore, MD, USA.
Robert N HooverDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.
Mitchell J MachielaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.ORCID 0000-0001-6538-9705
Karina Dalsgaard SørensenDepartment of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.ORCID 0000-0002-4902-5490
Michael BorreDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark.
William J BlotDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0003-1226-070X
Edward D YeboahUniversity of Ghana Medical School, Accra, Ghana.
James E MensahUniversity of Ghana Medical School, Accra, Ghana.ORCID 0000-0003-4133-1722
Yong-Jie LuCentre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, London, UK.ORCID 0000-0001-6174-6621
Hong-Wei ZhangSecond Military Medical University, Shanghai, China.
Ninghan FengWuxi Second Hospital, Nanjing Medical University, Wuxi, China.
Xueying MaoCentre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, London, UK.
Yudong WuDepartment of Urology, First Affiliated Hospital, The Academy of Medical Sciences, Zhengzhou University, Zhengzhou, China.
Shan-Chao ZhaoDepartment of Urology, Nanfang Hospital, Southern Medical University, Guangzhou, China.ORCID 0000-0002-1162-8077
Zan SunThe People's Hospital of Liaoning Proviouce, The People's Hospital of China Medical University, Shenyang, China.
Stephen N ThibodeauDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Shannon K McDonnellDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
Daniel J SchaidDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
Catharine M L WestDivision of Cancer Sciences, University of Manchester, Manchester Academic Health Science Centre, Radiotherapy Related Research, The Christie Hospital NHS Foundation Trust, Manchester, UK.ORCID 0000-0002-0839-3449
Gill BarnettUniversity of Cambridge Department of Oncology, Oncology Centre, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Christiane MaierHumangenetik Tuebingen, Tuebingen, Germany.
Thomas SchnoellerDepartment of Urology, University Hospital Ulm, Ulm, Germany.
Manuel LuedekeHumangenetik Tuebingen, Tuebingen, Germany.
Adam S KibelDivision of Urologic Surgery, Brigham and Womens Hospital, Boston, MA, USA.
Bettina F DrakeWashington University School of Medicine, St. Louis, MO, USA.
Olivier CussenotGRC 5 Predictive Onco-Urology, Sorbonne Université, Paris, France.
Geraldine Cancel-TassinGRC 5 Predictive Onco-Urology, Sorbonne Université, Paris, France.ORCID 0000-0002-9583-6382
Florence MenegauxExposome and Heredity, CESP (UMR 1018), Paris-Saclay Medical School, Paris-Saclay University, Inserm, Gustave Roussy, Villejuif, France.
Thérèse TruongExposome and Heredity, CESP (UMR 1018), Paris-Saclay Medical School, Paris-Saclay University, Inserm, Gustave Roussy, Villejuif, France.ORCID 0000-0002-2943-6786
Yves Akoli KoudouCancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University Paris-Saclay, Villejuif, France.
Esther M JohnDepartment of Medicine and Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA.
Eli Marie GrindedalDepartment of Medical Genetics, Oslo University Hospital, Oslo, Norway.
Lovise MaehleDepartment of Medical Genetics, Oslo University Hospital, Oslo, Norway.
Kay-Tee KhawClinical Gerontology Unit, University of Cambridge, Cambridge, UK.
Sue A InglesDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, USA.
Mariana C SternDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, USA.
Ana VegaFundación Pública Galega Medicina Xenómica, Santiago de Compostela, Spain.ORCID 0000-0002-7416-5137
Antonio Gómez-CaamañoDepartment of Radiation Oncology, Complexo Hospitalario Universitario de Santiago, SERGAS, Santiago de Compostela, Spain.ORCID 0000-0002-9773-4590
Laura FachalFundación Pública Galega Medicina Xenómica, Santiago de Compostela, Spain.
Barry S RosensteinDepartment of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Sarah L KernsDepartment of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI, USA.
Harry OstrerDepartment of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA.
Manuel R TeixeiraDepartment of Laboratory Genetics, Portuguese Oncology Institute of Porto (IPO Porto)/Porto Comprehensive Cancer Center, Porto, Portugal.ORCID 0000-0002-4896-5982
Paula PauloCancer Genetics Group, IPO Porto Research Center (CI-IPOP)/RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto)/Porto Comprehensive Cancer Center, Porto, Portugal.
Andreia BrandãoCancer Genetics Group, IPO Porto Research Center (CI-IPOP)/RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto)/Porto Comprehensive Cancer Center, Porto, Portugal.ORCID 0000-0003-0938-1543
Stephen WatyaUro Care, Kampala, Uganda.
Alexander LubwamaUro Care, Kampala, Uganda.
Jeannette T BensenDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Ebonee N ButlerDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
James L MohlerLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0002-7726-3795
Jack A TaylorEpidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.ORCID 0000-0001-5303-6398
Manolis KogevinasISGlobal, Barcelona, Spain.
Trinidad Dierssen-SotosCIBER Epidemiología y Salud Pública, Madrid, Spain.
Gemma Castaño-VinyalsISGlobal, Barcelona, Spain.ORCID 0000-0003-4468-1816
Lisa Cannon-AlbrightDivision of Epidemiology, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.ORCID 0000-0003-2602-3668
Craig C TeerlinkDivision of Epidemiology, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.
Chad D HuffDepartment of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Patrick PilieDepartment of Genitourinary Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Yao YuDepartment of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0002-2727-1746
Ryan J BohlenderDepartment of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0002-6347-0494
Jian GuDepartment of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0003-3499-0973
Sara S StromThe University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Luc MultignerUniv Rennes, Inserm, EHESP, Institut de recherche en santé, environnement et travail, Rennes, France.ORCID 0000-0003-3205-8568
Pascal BlanchetCHU de Pointe-à-Pitre, Univ Antilles, Univ Rennes, Inserm, EHESP, Institut de recherche en santé, environnement et travail, Pointe-à-Pitre, France.
Laurent BrureauCHU de Pointe-à-Pitre, Univ Antilles, Univ Rennes, Inserm, EHESP, Institut de recherche en santé, environnement et travail, Pointe-à-Pitre, France.
Radka KanevaMolecular Medicine Center, Department of Medical Chemistry and Biochemistry, Medical University of Sofia, Sofia, Bulgaria.
Chavdar SlavovDepartment of Urology and Alexandrovska University Hospital, Medical University of Sofia, Sofia, Bulgaria.
Vanio MitevMolecular Medicine Center, Department of Medical Chemistry and Biochemistry, Medical University of Sofia, Sofia, Bulgaria.
Robin J LeachDepartment of Cell Systems and Anatomy and Mays Cancer Center, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Hermann BrennerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0002-6129-1572
Xuechen ChenDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Bernd HolleczekSaarland Cancer Registry, Saarbrücken, Germany.
Ben SchöttkerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Eric A KleinCleveland Clinic Lerner Research Institute, Cleveland, OH, USA.ORCID 0000-0002-1783-0698
Ann W HsingDepartment of Medicine and Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA.
Rick A KittlesCity of Hope Comprehensive Cancer Center, Duarte, CA, USA.
Adam B MurphyDepartment of Urology, Northwestern University, Chicago, IL, USA.ORCID 0000-0001-9977-3473
Christopher J LogothetisDepartment of Genitourinary Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0002-6365-1711
Jeri KimDepartment of Genitourinary Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Susan L NeuhausenDepartment of Population Sciences, Beckman Research Institute of the City of Hope, Duarte, CA, USA.ORCID 0000-0001-5053-0390
Linda SteeleDepartment of Population Sciences, Beckman Research Institute of the City of Hope, Duarte, CA, USA.
Yuan Chun DingDepartment of Population Sciences, Beckman Research Institute of the City of Hope, Duarte, CA, USA.
William B IsaacsJames Buchanan Brady Urological Institute, Johns Hopkins Hospital and Medical Institution, Baltimore, MD, USA.
Barbara NemesureDepartment of Family, Population and Preventive Medicine, Stony Brook University, Stony Brook, NY, USA.
Anselm J M HennisDepartment of Family, Population and Preventive Medicine, Stony Brook University, Stony Brook, NY, USA.
John CarptenDepartment of Translational Genomics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Hardev PandhaThe University of Surrey, Guildford, UK.
Agnieszka MichaelThe University of Surrey, Guildford, UK.ORCID 0000-0002-7262-6227
Kim De RuyckGhent University, Faculty of Medicine and Health Sciences, Basic Medical Sciences, Ghent, Belgium.
Gert De MeerleerDepartment of Radiotherapy, Ghent University Hospital, Ghent, Belgium.
Piet OstDepartment of Radiotherapy, Ghent University Hospital, Ghent, Belgium.ORCID 0000-0002-2203-4848
Jianfeng XuProgram for Personalized Cancer Care and Department of Surgery, NorthShore University HealthSystem, Evanston, IL, USA.ORCID 0000-0002-1343-8752
Azad RazackDepartment of Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Jasmine LimDepartment of Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Soo-Hwang TeoCancer Research Malaysia, Outpatient Centre, Subang Jaya Medical Centre, Subang Jaya, Malaysia.ORCID 0000-0002-0444-590X
Lisa F NewcombDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Daniel W LinDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Jay H FowkeDepartment of Preventive Medicine, Division of Epidemiology, The University of Tennessee Health Science Center, Memphis, TN, USA.
Christine M Neslund-DudasDepartment of Public Health Sciences, Henry Ford Hospital, Detroit, MI, USA.
Benjamin A RybickiDepartment of Public Health Sciences, Henry Ford Hospital, Detroit, MI, USA.
Marija GamulinDivision of Medical Oncology, Urogenital Unit, Department of Oncology, University Hospital Centre Zagreb, Zagreb, Croatia.ORCID 0000-0003-2431-7910
Davor LesselInstitute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0003-4496-244X
Tomislav KulisDepartment of Urology, University Hospital Center Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia.ORCID 0000-0002-0895-5691
Nawaid UsmaniDepartment of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada.
Aswin AbrahamDepartment of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada.
Sandeep SinghalDepartment of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada.
Matthew ParliamentDepartment of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada.
Frank ClaessensDepartment of Cellular and Molecular Medicine, Molecular Endocrinology Laboratory, Leuven, Belgium.
Steven JoniauDepartment of Urology, University Hospitals Leuven, Leuven, Belgium.ORCID 0000-0003-3195-9890
Thomas Van den BroeckDepartment of Cellular and Molecular Medicine, Molecular Endocrinology Laboratory, Leuven, Belgium.
Manuela Gago-DominguezGenomic Medicine Group, Galician Foundation of Genomic Medicine, Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saúde, SERGAS, Santiago de Compostela, Spain.
Jose Esteban CastelaoGenetic Oncology Unit, CHUVI Hospital, Complexo Hospitalario Universitario de Vigo, Instituto de Investigación Biomédica Galicia Sur, Vigo, Spain.
Maria Elena MartinezMoores Cancer Center, Department of Family Medicine and Public Health, University of California San Diego, La Jolla, CA, USA.
Samantha LarkinScientific Education Support, Thames Ditton, Surrey, Formerly Cancer Sciences, University of Southampton, Southampton, UK.
Paul A TownsendSchool of Biosciences and Medicine, Faculty of Health and Medical Sciences, University of Surrey, Surrey, UK.
Claire Aukim-HastieScientific Education Support, Thames Ditton, UK.
William S BushDepartment of Population and Quantitative Health Sciences, Cleveland Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, USA.ORCID 0000-0002-9729-6519
Melinda C AldrichDivision of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0003-3833-8448
Dana C CrawfordDepartment of Population and Quantitative Health Sciences, Cleveland Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, USA.ORCID 0000-0002-6437-6248
Shiv SrivastavaDepartment of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center, Washington DC, USA.
Jennifer CullenDepartment of Population and Quantitative Health Sciences, Cleveland Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, USA.
Gyorgy PetrovicsDepartment of Surgery, Center for Prostate Disease Research, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.ORCID 0000-0003-3732-284X
Graham CaseyDepartment of Public Health Science, Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
Ying WangDepartment of Population Science, American Cancer Society, Kennesaw, GA, USA.ORCID 0000-0002-1241-6252
Yao TetteyKorle Bu Teaching Hospital, Accra, Ghana.
Joseph LachanceSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.ORCID 0000-0002-4650-3741
Wei TangLaboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.ORCID 0000-0002-7089-4391
Richard B BiritwumKorle Bu Teaching Hospital, Accra, Ghana.
Andrew A AdjeiDepartment of Pathology, University of Ghana Medical School, Accra, Ghana.
Evelyn TayKorle Bu Teaching Hospital, Accra, Ghana.
Ann TrueloveWestat, Rockville, MD, USA.
Shelley NiwaWestat, Rockville, MD, USA.
Kosj YamoahDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA.ORCID 0000-0001-9055-3538
Koveela GovindasamiThe Institute of Cancer Research, London, UK.
Anand P ChokkalingamSchool of Public Health, University of California, Berkeley, Berkeley, CA, USA.
Jacob M KeatonDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Jacklyn N HellwegeDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Peter E ClarkAtrium Health/Levine Cancer Institute, Charlotte, NC, USA.
Mohamed JallohHôpital Général Idrissa Pouye, Dakar, Senegal.ORCID 0000-0002-2190-328X
Serigne M GueyeHôpital Général Idrissa Pouye, Dakar, Senegal.
Lamine NiangHôpital Général Idrissa Pouye, Dakar, Senegal.
Olufemi OgunbiyiDepartment of Pathology, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Olayiwola ShittuDepartment of Surgery, College of Medicine, University of Ibadan and Univerity College Hospital, Ibadan, Nigeria.
Olukemi AmoduInstitute of Child Health, College of Medicine, University of Ibadan and University College Hospital, Ibadan, Nigeria.
Akindele O AdebiyiClinical Epidemiology Unit, Department of Community Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria.ORCID 0000-0003-1869-7910
Oseremen I Aisuodionoe-ShadrachCollege of Health Sciences, University of Abuja, University of Abuja Teaching Hospital and Cancer Science Center, Abuja, Nigeria.
Hafees O AjibolaCollege of Health Sciences, University of Abuja, University of Abuja Teaching Hospital and Cancer Science Center, Abuja, Nigeria.
Mustapha A JamdaCollege of Health Sciences, University of Abuja, University of Abuja Teaching Hospital and Cancer Science Center, Abuja, Nigeria.
Olabode P OluwoleCollege of Health Sciences, University of Abuja, University of Abuja Teaching Hospital and Cancer Science Center, Abuja, Nigeria.
Maxwell NwegbuCollege of Health Sciences, University of Abuja, University of Abuja Teaching Hospital and Cancer Science Center, Abuja, Nigeria.
Ben Adusei37 Military Hospital, Accra, Ghana.
Sunny Mante37 Military Hospital, Accra, Ghana.ORCID 0000-0002-8952-8594
Afua Darkwa-AbrahamsKorle Bu Teaching Hospital, Accra, Ghana.
Halimatou DiopLaboratoires Bacteriologie et Virologie, Hôpital Aristide Le Dantec, Dakar, Senegal.
Susan M GundellCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Monique J RoobolDepartment of Urology, Erasmus University Medical Center, Rotterdam, the Netherlands.ORCID 0000-0001-6967-1708
Guido JensterDepartment of Urology, Erasmus University Medical Center, Rotterdam, the Netherlands.ORCID 0000-0002-8658-2552
Ron H N van SchaikDepartment of Clinical Chemistry, Erasmus University Medical Center, Rotterdam, the Netherlands.
Jennifer J HuThe University of Miami School of Medicine, Sylvester Comprehensive Cancer Center, Miami, FL, USA.ORCID 0000-0002-0021-5699
Maureen SandersonDepartment of Family and Community Medicine, Meharry Medical College, Nashville, TN, USA.
Linda KachuriDepartment of Epidemiology and Population Health, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-3226-4727
Rohit VarmaSouthern California Eye Institute, CHA Hollywood Presbyterian Medical Center, Los Angeles, CA, USA.
Roberta McKean-CowdinDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Mina TorresSouthern California Eye Institute, CHA Hollywood Presbyterian Medical Center, Los Angeles, CA, USA.
Michael H PreussThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0001-5266-8465
Ruth J F LoosThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-8532-5087
Matthew ZawistowskiDepartment of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.ORCID 0000-0002-3005-083X
Sebastian ZöllnerDepartment of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.ORCID 0000-0001-7362-156X
Zeyun LuDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0002-3511-6850
Stephen K Van Den EedenDivision of Research, Kaiser Permanente, Oakland, CA, USA.ORCID 0000-0002-5599-8387
Douglas F EastonCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.ORCID 0000-0003-2444-3247
Stefan AmbsLaboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.ORCID 0000-0001-7651-9309
Todd L EdwardsDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0003-4318-6119
Reedik MägiEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID 0000-0002-2964-6011
Timothy R RebbeckHarvard TH Chan School of Public Health and Division of Population Sciences, Dana Farber Cancer Institute, Boston, MA, USA.ORCID 0000-0002-4799-1900
Lars FritscheDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-2110-1690
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.ORCID 0000-0002-2324-3393
Sonja I BerndtDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.
Fredrik WiklundDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.ORCID 0000-0002-4623-0544
Hidewaki NakagawaLaboratory for Cancer Genomics, RIKEN Center of Integrative Medical Sciences, Yokohama, Japan.ORCID 0000-0003-1807-772X
John S WitteDepartment of Epidemiology and Population Health, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0003-0146-1434
J Michael GazianoDivision of Aging, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Amy C JusticeYale School of Medicine, New Haven, CT, USA.ORCID 0000-0003-0139-5502
Nick MancusoCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0002-9352-5927
Chikashi TeraoLaboratory for Statistical and Translational Genetics, Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan.ORCID 0000-0002-6452-4095
Rosalind A EelesThe Institute of Cancer Research, London, UK.ORCID 0000-0002-3698-6241
Zsofia Kote-JaraiThe Institute of Cancer Research, London, UK.ORCID 0000-0002-6329-5155
Ravi K MadduriArgonne National Laboratory, Lemont, IL, USA.ORCID 0000-0003-2130-2887
David V Conti *Center for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0002-2941-7833
Christopher A Haiman *Center for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. haiman@usc.edu.ORCID 0000-0002-0097-9971
University of Southern California · USBrigham and Women's Hospital · USThe University of Texas MD Anderson Cancer Center · USUniversity of Cambridge · GBInserm · FRNational Cancer Institute · USHarvard University · USThe University of Tokyo · JPUniversity of Copenhagen · DKAmerican Cancer Society · USInstitute of Cancer Research · GBKarolinska Institutet · SERIKEN Center for Integrative Medical Sciences · JPUniversity of Abuja Teaching Hospital · NGUniversity of Ghana · GHUniversity of Ibadan · NGJohns Hopkins University · USNational Institutes of Health · USThe University of Melbourne · AUUniversity Hospital Centre Zagreb · HR

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Statistical Methods for Integrative Genomics in CancerP01CA196569 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI David V Conti · 2016 to 2026
$25.5M
Research on Prostate Cancer in Men of African Ancestry: Defining the Roles of Genetics, Immunity and Stress (RESPOND)U19CA214253 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HAIMAN, CHRISTOPHER ALAN · 2018 to 2023
$16.8M
Building Interdisciplinary Research Careers in Women's HealthK12HD043483 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HARTMANN, KATHERINE E, MAJOR, AMY S · 2002 to 2023
$10.3M
Leveraging Prospective Cancer Epidemiology Cohorts and Novel Methods to Improve Polygenic Risk ScoresU01CA261339 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Fei Chen, David V Conti · 2021 to 2026
$5.2M
Multiethnic GWAS and TWAS to Inform Risk Prediction for Prostate CancerU01CA257328 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CONTI, DAVID V, HAIMAN, CHRISTOPHER ALAN · 2021 to 2025
$3.1M
An integrative multi-omics approach to characterize prostate cancer risk in diverse populationsR01CA258808 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Nicholas Mancuso · 2021 to 2026
$2.5M
Building Interdisciplinary Research Careers in Women's HealthK12AR084232 · NIAMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI AMY S MAJOR, Digna R Velez Edwards · 2023 to 2026
$1.3M
Integrating Genomics and Metabolomics to Develop Predictive Models of Prostate Cancer in Multiethnic MenR00CA246063 · NCI · FRED HUTCHINSON CANCER CENTER · PI DARST, BURCU FRANCES · 2022 to 2024
$830k
Cancer Research UK 15064Cancer Research UK 21332Cancer Research UK 29017Cancer Research UK 29019Cancer Research UK 29186NCATS NIH HHS UL1 TR001863NCI NIH HHS P01 CA196569NCI NIH HHS R00 CA246063NCI NIH HHS R01 CA258808NCI NIH HHS U01 CA257328NCI NIH HHS U01 CA261339NCI NIH HHS U19 CA214253NIAMS NIH HHS K12 AR084232NICHD NIH HHS K12 HD043483
6 · The paper itself

Abstract

The transferability and clinical value of genetic risk scores (GRSs) across populations remain limited due to an imbalance in genetic studies across ancestrally diverse populations. Here we conducted a multi-ancestry genome-wide association study of 156,319 prostate cancer cases and 788,443 controls of European, African, Asian and Hispanic men, reflecting a 57% increase in the number of non-European cases over previous prostate cancer genome-wide association studies. We identified 187 novel risk variants for prostate cancer, increasing the total number of risk variants to 451. An externally replicated multi-ancestry GRS was associated with risk that ranged from 1.8 (per standard deviation) in African ancestry men to 2.2 in European ancestry men. The GRS was associated with a greater risk of aggressive versus non-aggressive disease in men of African ancestry (P = 0.03). Our study presents novel prostate cancer susceptibility loci and a GRS with effective risk stratification across ancestry groups.

Indexed as

Genetic Predisposition to DiseaseProstatic NeoplasmsAsian PeopleBlack PeopleGenome-Wide Association StudyHispanic or LatinoHumansMalePolymorphism, Single NucleotideRisk FactorsWhite People

Identifiers

PMID37945903
PMCPMC10841479
OpenAlexW4388541037

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