ArticleNature chemistry2024
Discovery and synthesis of atropisomerically chiral acyl-substituted stable vinyl sulfoxonium ylides.
Article in Nature chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed.
- Enantioselective Synthesis of Atropisomeric 1,3-Dienes via Platinum-Catalyzed Hydrosilylation of 1,3-Enynes.Angewandte Chemie (International ed. in English) · 2026Article
- Divergent synthesis of γ-lactones and cyclopropanes via efficient [1 + 4] and [1 + 2] annulations of amide-sulfoxonium ylides.Communications chemistry · 2026Article
- Fluorescence mapping of atropisomer populations enabled by through-space conjugation.Nature communications · 2026Article
- Copper-Catalyzed Asymmetric Cyclizative Sulfinamidation: Forging Indole-Based Stereogenic Sulfur(IV) Centers and Atropisomeric Chirality.ACS central science · 2025Article
- Azapeptide Atropisomers From Late-StageThe Journal of organic chemistry · 2025Article
- Catalyst-Free Direct Hydrocarbonation of Terminal Alkynes Toward E-Alkene Substituted Stabilized Sulfoxonium Ylides.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Cu(I)-catalysed chemo-, regio-, and stereoselective radical 1,2-carboalkynylation with two different terminal alkynes.Nature communications · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Atropisomerism is a type of conformational chirality that plays a critical role in various fields of chemistry, including synthetic, medicinal and material chemistry, and its impact has been widely recognized. Although chiral atropisomerism in rotationally restricted aryl-aryl bonds has garnered substantial interest and led to important discoveries in chiral catalysts and drug development, the exploration of non-aryl atropisomers has fallen behind. Here we reveal a previously unexplored form of non-aryl atropisomerism by linking a sterically congested olefin to a sulfoxonium ylide. A streamlined synthetic approach to these novel molecules was developed through the hydrofunctionalization of alkynyl sulfoxonium ylides. Notably, an enantioselective organocatalytic strategy was developed to prepare these non-aryl atropisomers in high optical purity. This form of atropisomerism offers new routes for investigating the functional properties of axially chiral molecules.
Identifiers
37945832What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.