Evidence map›Paper›PMID 37945817›Full record

ArticleCommunications medicine2023

The grade of individual prostate cancer lesions predicted by magnetic resonance imaging and positron emission tomography.

Erik Nilsson, Kristina Sandgren, Josefine Grefve, Joakim Jonsson, Jan Axelsson, Angsana Keeratijarut Lindberg, Karin Söderkvist, Camilla Thellenberg Karlsson, Anders Widmark, Lennart Blomqvist and 4 more

Abstract read
In one paragraph

Article in Communications medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Erik NilssonDepartment of Radiation Sciences, Radiation Physics, Umeå University, Umeå, Sweden. erik.a.nilsson@umu.se.ORCID http://orcid.org/0000-0001-8747-4759
Kristina SandgrenDepartment of Radiation Sciences, Radiation Physics, Umeå University, Umeå, Sweden.ORCID http://orcid.org/0000-0001-8890-241X
Josefine GrefveDepartment of Radiation Sciences, Radiation Physics, Umeå University, Umeå, Sweden.ORCID http://orcid.org/0000-0002-3488-7784
Joakim JonssonDepartment of Radiation Sciences, Radiation Physics, Umeå University, Umeå, Sweden.
Jan AxelssonDepartment of Radiation Sciences, Radiation Physics, Umeå University, Umeå, Sweden.
Angsana Keeratijarut LindbergDepartment of Radiation Sciences, Radiation Physics, Umeå University, Umeå, Sweden.
Karin SöderkvistDepartment of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden.ORCID http://orcid.org/0000-0002-3683-3763
Camilla Thellenberg KarlssonDepartment of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden.ORCID http://orcid.org/0000-0002-7061-7255
Anders WidmarkDepartment of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden.
Lennart BlomqvistDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Solna, Sweden.
Sara StrandbergDepartment of Radiation Sciences, Diagnostic Radiology, Umeå University, Umeå, Sweden.ORCID http://orcid.org/0000-0002-0943-8178
Katrine RiklundDepartment of Radiation Sciences, Diagnostic Radiology, Umeå University, Umeå, Sweden.ORCID http://orcid.org/0000-0001-5227-8117
Anders BerghDepartment of Medical Biosciences, Pathology, Umeå University, Umeå, Sweden.
Tufve NyholmDepartment of Radiation Sciences, Radiation Physics, Umeå University, Umeå, Sweden.ORCID http://orcid.org/0000-0002-8971-9788

Funding

Cancerfonden (Swedish Cancer Society) 21 1594 PjCancer Research Foundation in Northern Sweden (Northern Sweden Cancer Foundation) AMP 22-1089
6 · The paper itself

Abstract

backgroundMultiparametric magnetic resonance imaging (mpMRI) and positron emission tomography (PET) are widely used for the management of prostate cancer (PCa). However, how these modalities complement each other in PCa risk stratification is still largely unknown. We aim to provide insights into the potential of mpMRI and PET for PCa risk stratification.

methodsWe analyzed data from 55 consecutive patients with elevated prostate-specific antigen and biopsy-proven PCa enrolled in a prospective study between December 2016 and December 2019. [

resultsWe find that the maximum standardized uptake value (SUV

conclusionsBy co-registering whole-mount histopathology and in-vivo imaging we show that mpMRI and PET can distinguish between lower- and higher-grade prostate cancer, using partially discriminative cut-off values.

Identifiers

PMID37945817
PMCPMC10636013

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.