ArticleNature communications2023
Failure to apply standard limit-of-detection or limit-of-quantitation criteria to specialized pro-resolving mediator analysis incorrectly characterizes their presence in biological samples.
Abstract readLetter
In one paragraph
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed.
- Urinary prostanoids are elevated by anti-TNF and anti-IL6 receptor disease-modifying antirheumatic drugs but are not predictive of response to treatment in early rheumatoid arthritis.Arthritis research & therapy · 2024Trial
- Enriched Marine Oil Supplement Increases Specific Plasma Specialized Pro-Resolving Mediators in Adults with Obesity.The Journal of nutrition · 2022Trial
- From lipid detection to biological meaning: raising standards for oxylipin signaling.Journal of lipid research · 2026Article
- Biosynthesis and analytics of specialized pro-resolving mediators: facts and faults.Journal of lipid research · 2026Review
- Tocotrienol metabolites redirect lipid mediator production in innate immune cells towards inflammation resolution.Acta pharmaceutica Sinica. B · 2026Article
- sPLAScience advances · 2026Article
- Differential Regulation of Inflammatory and Pro-Resolving Lipid Mediators in Chronic Coronary Syndrome Across Cardiometabolic Phenotypes.International journal of molecular sciences · 2026Observational
- Validated bioanalysis of oxylipins confirms specialized pro-resolving mediator formation in vitro and in vivo.Journal of lipid research · 2026Article
- G protein-coupled receptors and inflammation resolution signaling networks in the heart: Pharmacology and potential for innovative therapeutics.Pharmacological reviews · 2026Review
- Emerging complexities of phospholipid metabolism in adipose tissue.Molecules and cells · 2026Review
- Annexin A1 and Dexamethasone Treatment in Hospitalized COVID-19 Patients: Impact on Disease Recovery and Evidence for an Interplay Between Proresolving Mediators.Biomolecules · 2026Article
- Revisiting Bill Lands' Hypotheses: HUFA Balance, Immuno-Metabolic Regulation, and Conflicting Clinical Evidence.Nutrients · 2026Review
- Effects of Antarctic krill oil on lipid profiles and SPM levels in rats over time.NPJ science of food · 2026Article
- Maresins.Biomolecules · 2026Review
- Failed resolution as a mechanistic basis of difficult-to-treat rheumatoid arthritis: stromal-myeloid crosstalk in the synovium and emerging resolution-restoring therapies.Frontiers in immunology · 2026Review
- The future of brain tumor treatment: integrating platelet-based liquid biopsy, advanced drug delivery systems, and eicosanoid inhibition.Frontiers in pharmacology · 2026Review
- Predictive biomarkers for precision treatment in rheumatoid arthritis: are we there yet?Frontiers in pharmacology · 2026Review
- The role of ALOX15 in inflammation-related diseases.Frontiers in immunology · 2026Review
- From lipid switch to tissue repair: how resolvins reprogram macrophage polarization and function.Immunometabolism (Cobham, Surrey) · 2026Review
- 12/15-lipoxygenase orchestrates murine wound healing via PPARγ-activating oxylipins acting holistically to dampen inflammation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Valerie B O'DonnellSystems Immunity Research Institute, School of Medicine, Cardiff University, CF14 4XN, Cardiff, Wales, UK. O-donnellvb@cardiff.ac.uk.ORCID 0000-0003-4089-8460
Nils H SchebbChair of Food Chemistry, Faculty of Mathematics and Natural Sciences University of Wuppertal, Gausstraße 20, 42119, Wuppertal, Germany.
Ginger L MilneDivision of Clinical Pharmacology, Vanderbilt University, 502A Robinson Research Building, Nashville, TN, 37232-6602, USA.
Michael P MurphyMedical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge, CB2 0XY, UK.ORCID 0000-0003-1115-9618
Christopher P ThomasSchool of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, CF10 3AT, UK.
Dieter SteinhilberInstitute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Str. 9, 60438, Frankfurt, Germany.ORCID 0000-0001-8905-5208
Stacy L GelhausDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, 15261, USA.ORCID 0000-0001-9083-6933
Hartmut KühnInstitute of Biochemistry, University Medicine Berlin - Charité, Berlin, Germany.
Michael H GelbDepartment of Chemistry, University of Washington, Seattle, WA, 98195, USA.
Per-Johan JakobssonRheumatology Unit, Dep. of Medicine, Solna, Karolinska Institutet & Karolinska University Hospital, Stockholm, Sweden.ORCID 0000-0001-7665-9715
Ian A BlairDepartment of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.ORCID 0000-0003-0366-8658
Robert C MurphyDepartment of Pharmacology, University of Colorado Denver, Aurora, CO, 80045, USA.
Bruce A FreemanDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, 15261, USA.ORCID 0000-0002-2028-8369
Alan R BrashDepartment of Pharmacology, Vanderbilt University, Nashville, TN, 37232, USA.
Garret A FitzGeraldInstitute for Translational Medicine and Therapeutics, Smilow Center for Translational Research, University of Pennsylvania, Philadelphia, PA, 19104, USA. garret@upenn.edu.ORCID 0000-0002-5885-6819
Funding
Translational Research Support CoreP30ES013508 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI Rebecca A Simmons · 2006 to 2026
$35.3MVanderbilt Diabetes Research CenterP30DK020593 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI OWEN P MCGUINNESS · 2012 to 2026
$29.3MNIDDK NIH HHS P30 DK020593NIEHS NIH HHS P30 ES013508Wellcome Trust
Abstract
PubMed holds no abstract for this paper.
Indexed as
Docosahexaenoic AcidsInflammationHumansDocosahexaenoic Acids
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.